1. Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease.

    Journal of Experimental Medicine 212(8):1303 (2015) PMID 26169940 PMCID PMC4516799

    The primacy of the gastrointestinal (GI) tract in dictating the outcome of graft-versus-host disease (GVHD) is broadly accepted; however, the mechanisms controlling this effect are poorly understood. Here, we demonstrate that GVHD markedly enhances alloantigen presentation within the mesenteric ...
  2. c-Myb is required for plasma cell migration to bone marrow after immunization or infection.

    Journal of Experimental Medicine 212(7):1001 (2015) PMID 26077717 PMCID PMC4493410

    Plasma cell migration is crucial to immunity, but little is known about the molecular regulators of their migratory programs. Here, we detail the critical role of the transcription factor c-Myb in determining plasma cell location. In the absence of c-Myb, no IgG(+) antigen-specific plasma cells ...
  3. A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity.

    PLoS ONE 10(7):e0134326 (2015) PMID 26221731 PMCID PMC4519308

    We identified Mrpl44 in a search for mammalian proteins that contain RNase III domains. This protein was previously found in association with the mitochondrial ribosome of bovine liver extracts. However, the precise Mrpl44 localization had been unclear. Here, we show by immunofluorescence micros...
  4. T cell signaling. Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion.

    Science 346(6213):1123 (2014) PMID 25430770

    T cell responses are initiated by antigen and promoted by a range of costimulatory signals. Understanding how T cells integrate alternative signal combinations and make decisions affecting immune response strength or tolerance poses a considerable theoretical challenge. Here, we report that T ce...
  5. T cell signaling. Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion.

    Science 346(6213):1123 (2014) PMID 25430770

    T cell responses are initiated by antigen and promoted by a range of costimulatory signals. Understanding how T cells integrate alternative signal combinations and make decisions affecting immune response strength or tolerance poses a considerable theoretical challenge. Here, we report that T ce...
  6. T cell signaling. Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion.

    Science 346(6213):1123 (2014) PMID 25430770

    T cell responses are initiated by antigen and promoted by a range of costimulatory signals. Understanding how T cells integrate alternative signal combinations and make decisions affecting immune response strength or tolerance poses a considerable theoretical challenge. Here, we report that T ce...
  7. Peripheral natural killer cell maturation depends on the transcription factor Aiolos.

    EMBO Journal 33(22):2721 (2014) PMID 25319415 PMCID PMC4282578

    Natural killer (NK) cells are an innate lymphoid cell lineage characterized by their capacity to provide rapid effector functions, including cytokine production and cytotoxicity. Here, we identify the Ikaros family member, Aiolos, as a regulator of NK-cell maturation. Aiolos expression is initia...
  8. Peripheral natural killer cell maturation depends on the transcription factor Aiolos.

    EMBO Journal 33(22):2721 (2014) PMID 25319415 PMCID PMC4282578

    Natural killer (NK) cells are an innate lymphoid cell lineage characterized by their capacity to provide rapid effector functions, including cytokine production and cytotoxicity. Here, we identify the Ikaros family member, Aiolos, as a regulator of NK-cell maturation. Aiolos expression is initia...
  9. Peripheral natural killer cell maturation depends on the transcription factor Aiolos.

    EMBO Journal 33(22):2721 (2014) PMID 25319415

    Natural killer (NK) cells are an innate lymphoid cell lineage characterized by their capacity to provide rapid effector functions, including cytokine production and cytotoxicity. Here, we identify the Ikaros family member, Aiolos, as a regulator of NK-cell maturation. Aiolos expression is initia...
  10. Peripheral natural killer cell maturation depends on the transcription factor Aiolos.

    EMBO Journal 33(22):2721 (2014) PMID 25319415 PMCID PMC4282578

    Natural killer (NK) cells are an innate lymphoid cell lineage characterized by their capacity to provide rapid effector functions, including cytokine production and cytotoxicity. Here, we identify the Ikaros family member, Aiolos, as a regulator of NK-cell maturation. Aiolos expression is initia...
  11. Peripheral natural killer cell maturation depends on the transcription factor Aiolos.

    EMBO Journal 33(22):2721 (2014) PMID 25319415

    Natural killer (NK) cells are an innate lymphoid cell lineage characterized by their capacity to provide rapid effector functions, including cytokine production and cytotoxicity. Here, we identify the Ikaros family member, Aiolos, as a regulator of NK-cell maturation. Aiolos expression is initia...
  12. Complexity of cytokine network regulation of innate lymphoid cells in protective immunity.

    Cytokine 70(1):1 (2014) PMID 24972988

    The body's surface provides a critical barrier shielding us from various mechanical and pathogenic insults by virtue of the physical protection it provides and the presence of specialized populations of innate lymphoid cells (ILCs) that sense inflammatory signals induced by pathogens. This respo...
  13. Complexity of cytokine network regulation of innate lymphoid cells in protective immunity.

    Cytokine 70(1):1 (2014) PMID 24972988

    The body's surface provides a critical barrier shielding us from various mechanical and pathogenic insults by virtue of the physical protection it provides and the presence of specialized populations of innate lymphoid cells (ILCs) that sense inflammatory signals induced by pathogens. This respo...
  14. Nfil3 is required for the development of all innate lymphoid cell subsets.

    Journal of Experimental Medicine 211(9):1733 (2014) PMID 25092873 PMCID PMC4144736

    Innate lymphoid cell (ILC) populations protect against infection and are essential for lymphoid tissue formation and tissue remodeling after damage. Nfil3 is implicated in the function of adaptive immune lineages and NK cell development, but it is not yet known if Nfil3 regulates other innate ly...
  15. Nfil3 is required for the development of all innate lymphoid cell subsets.

    Journal of Experimental Medicine 211(9):1733 (2014) PMID 25092873 PMCID PMC4144736

    Innate lymphoid cell (ILC) populations protect against infection and are essential for lymphoid tissue formation and tissue remodeling after damage. Nfil3 is implicated in the function of adaptive immune lineages and NK cell development, but it is not yet known if Nfil3 regulates other innate ly...
  16. Nfil3 is required for the development of all innate lymphoid cell subsets.

    Journal of Experimental Medicine 211(9):1733 (2014) PMID 25092873 PMCID PMC4144736

    Innate lymphoid cell (ILC) populations protect against infection and are essential for lymphoid tissue formation and tissue remodeling after damage. Nfil3 is implicated in the function of adaptive immune lineages and NK cell development, but it is not yet known if Nfil3 regulates other innate ly...
  17. Id2 represses E2A-mediated activation of IL-10 expression in T cells.

    Blood 123(22):3420 (2014) PMID 24723679

    Interleukin-10 (IL-10) is a key immunoregulatory cytokine that functions to prevent inflammatory and autoimmune diseases. Despite the critical role for IL-10 produced by effector CD8(+) T cells during pathogen infection and autoimmunity, the mechanisms regulating its production are poorly unders...
  18. Id2 represses E2A-mediated activation of IL-10 expression in T cells.

    Blood 123(22):3420 (2014) PMID 24723679

    Interleukin-10 (IL-10) is a key immunoregulatory cytokine that functions to prevent inflammatory and autoimmune diseases. Despite the critical role for IL-10 produced by effector CD8(+) T cells during pathogen infection and autoimmunity, the mechanisms regulating its production are poorly unders...
  19. Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.

    PLoS Pathogens 10(5):e1004134 (2014) PMID 24809749 PMCID PMC4014316

    Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with ...
  20. Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.

    PLoS Pathogens 10(5):e1004134 (2014) PMID 24809749 PMCID PMC4014316

    Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with ...