1. Unraveling N-Terminal Pro-B-Type Natriuretic Peptide: Another Piece to a Very Complex Puzzle in Heart Failure Patients.

    Clinical Chemistry 61(8):1016 (2015) PMID 26078443

  2. Multiple biomarkers including cardiac troponins T and I measured by high-sensitivity assays, as predictors of long-term mortality in patients with chronic renal failure who underwent dialysis.

    The American Journal of Cardiology 115(11):1601 (2015) PMID 25851798

    There is a high cardiac mortality in patients on long-term renal dialysis. No studies have reported long-term outcomes relating to both high-sensitivity cardiac troponin T (hs-cTnT) and high-sensitivity cardiac troponin I (hs-cTnI) in these patients. Patients who underwent long-term dialysis at ...
  3. Midregional proadrenomedullin predicts mortality and major adverse cardiac events in patients presenting with chest pain: results from the CHOPIN trial.

    Academic Emergency Medicine 22(5):554 (2015) PMID 25908114

    Chest pain is a common complaint to emergency departments (EDs) and clinical risk factors are used to predict which patients are at risk for worse outcomes and mortality. The goal was to assess the novel biomarker midregional proadrenomedullin (MR-proADM) in prediction of mortality and major adv...
  4. Diagnosis of type 1 and type 2 myocardial infarction using a high-sensitivity cardiac troponin I assay with sex-specific 99th percentiles based on the third universal definition of myocardial infarction classification system.

    Clinical Chemistry 61(4):657 (2015) PMID 25672334

    The frequency and characteristics of myocardial infarction (MI) subtypes per the Third Universal Definition of MI (TUDMI) classification system using high-sensitivity (hs) cardiac troponin assays with sex-specific cutoffs is not well known. We sought to describe the diagnostic characteristics of...
  5. Cardiac troponin assays: a review of quantitative point-of-care devices and their efficacy in the diagnosis of myocardial infarction.

    Clinical Chemistry and Laboratory Medicine 53(5):665 (2015) PMID 25324453

    Cardiac troponin (cTn) I and T are released from myocardial cells following necrosis, i.e., cell death. An accurate measure of cTn concentrations in a patient's blood following ischemia/chest pain can enable providers to determine whether or not a myocardial infarction (MI) has occurred. Point-o...
  6. Electronic medical record-based performance improvement project to document and reduce excessive cardiac troponin testing.

    Clinical Chemistry 61(3):498 (2015) PMID 25538265

    We assessed the utilization rationale behind provider ordering of cardiac troponin I (cTnI) testing for the diagnosis of myocardial infarction after implementation of a hospital-wide serial order protocol. During 2 months in 2013, any request for additional cTnI testing within 30 days of the ini...
  7. Electronic medical record-based performance improvement project to document and reduce excessive cardiac troponin testing.

    Clinical Chemistry 61(3):498 (2015) PMID 25538265

    We assessed the utilization rationale behind provider ordering of cardiac troponin I (cTnI) testing for the diagnosis of myocardial infarction after implementation of a hospital-wide serial order protocol. During 2 months in 2013, any request for additional cTnI testing within 30 days of the ini...
  8. Cardiac troponin testing is overused after the rule-in or rule-out of myocardial infarction.

    Clinical Chemistry 61(2):436 (2015) PMID 25388431

  9. Cardiac troponin testing is overused after the rule-in or rule-out of myocardial infarction.

    Clinical Chemistry 61(2):436 (2015) PMID 25388431

  10. Type 2 myocardial infarction. Potential hazards of nomenclature systems: user discretion advised.

    International Journal of Cardiology 179:373 (2015) PMID 25464489

  11. Type 2 myocardial infarction. Potential hazards of nomenclature systems: User discretion advised.

    International Journal of Cardiology 179:373 (2015) PMID 25464489

  12. Type 2 myocardial infarction. Potential hazards of nomenclature systems: User discretion advised

    International Journal of Cardiology 179:373 (2015)

  13. High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study.

    British Medical Journal (Abstracts) 350:g7873 (2015) PMID 25609052

    To evaluate the diagnosis of myocardial infarction using a high sensitivity troponin I assay and sex specific diagnostic thresholds in men and women with suspected acute coronary syndrome. Prospective cohort study. Regional cardiac centre, United Kingdom. Consecutive patients with suspected acut...
  14. High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study.

    British Medical Journal (Abstracts) 350:g7873 (2015) PMID 25609052

    To evaluate the diagnosis of myocardial infarction using a high sensitivity troponin I assay and sex specific diagnostic thresholds in men and women with suspected acute coronary syndrome. Prospective cohort study. Regional cardiac centre, United Kingdom. Consecutive patients with suspected acut...
  15. High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study.

    British Medical Journal (Abstracts) 350:g7873 (2015) PMID 25609052 PMCID PMC4301191

    To evaluate the diagnosis of myocardial infarction using a high sensitivity troponin I assay and sex specific diagnostic thresholds in men and women with suspected acute coronary syndrome. Prospective cohort study. Regional cardiac centre, United Kingdom. Consecutive patients with suspected acut...
  16. High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study.

    British Medical Journal (Abstracts) 350:g7873 (2015) PMID 25609052 PMCID PMC4301191

    To evaluate the diagnosis of myocardial infarction using a high sensitivity troponin I assay and sex specific diagnostic thresholds in men and women with suspected acute coronary syndrome. Prospective cohort study. Regional cardiac centre, United Kingdom. Consecutive patients with suspected acut...
  17. Cardiac troponin changes to distinguish type 1 and type 2 myocardial infarction and 180-day mortality risk.

    European Heart Journal: Acute Cardiovascular Care 3(4):317 (2014) PMID 24965188

    To determine the ability of serial cardiac troponin (cTnI) changes (delta) to distinguish type 1 and type 2 myocardial infarction (MI) (excluding all ST-segment elevation MIs (STEMIs)) and describe the diagnostic accuracy and 180-day mortality in MI versus no-MI patients. Serial cTnIs were measu...
  18. Cardiac troponin changes to distinguish type 1 and type 2 myocardial infarction and 180-day mortality risk.

    European Heart Journal: Acute Cardiovascular Care 3(4):317 (2014) PMID 24965188

    To determine the ability of serial cardiac troponin (cTnI) changes (delta) to distinguish type 1 and type 2 myocardial infarction (MI) (excluding all ST-segment elevation MIs (STEMIs)) and describe the diagnostic accuracy and 180-day mortality in MI versus no-MI patients. Serial cTnIs were measu...
  19. Cardiac troponin changes to distinguish type 1 and type 2 myocardial infarction and 180-day mortality risk.

    European Heart Journal: Acute Cardiovascular Care 3(4):317 (2014) PMID 24965188

    To determine the ability of serial cardiac troponin (cTnI) changes (delta) to distinguish type 1 and type 2 myocardial infarction (MI) (excluding all ST-segment elevation MIs (STEMIs)) and describe the diagnostic accuracy and 180-day mortality in MI versus no-MI patients. Serial cTnIs were measu...
  20. Improving the 510(k) FDA process for cardiac troponin assays: in search of common ground.

    Clinical Chemistry 60(10):1273 (2014) PMID 25114274