1. Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal

    Cell 160(5):842 (2015)

    Low energy states delay aging in multiple species, yet mechanisms coordinating energetics and longevity across tissues remain poorly defined. The conserved energy sensor AMP-activated protein kinase (AMPK) and its corresponding phosphatase calcineurin modulate longevity via the CREB re...
  2. Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal.

    Cell 160(5):842 (2015) PMID 25723162 PMCID PMC4392909

    Low energy states delay aging in multiple species, yet mechanisms coordinating energetics and longevity across tissues remain poorly defined. The conserved energy sensor AMP-activated protein kinase (AMPK) and its corresponding phosphatase calcineurin modulate longevity via the CREB regulated tr...
  3. Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal.

    Cell 160(5):842 (2015) PMID 25723162

    Low energy states delay aging in multiple species, yet mechanisms coordinating energetics and longevity across tissues remain poorly defined. The conserved energy sensor AMP-activated protein kinase (AMPK) and its corresponding phosphatase calcineurin modulate longevity via the CREB regulated tr...
  4. SnapShot: Mammalian Sirtuins.

    Cell 159(4):956 (2014) PMID 25417168

    The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-bind...
  5. SnapShot: Mammalian Sirtuins.

    Cell 159(4):956 (2014) PMID 25417168 PMCID PMC4337867

    The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-bind...
  6. SnapShot: Mammalian Sirtuins.

    Cell 159(4):956 (2014) PMID 25417168

    The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-bind...
  7. SnapShot: Mammalian Sirtuins.

    Cell 159(4):956 (2014) PMID 25417168

    The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-bind...
  8. SnapShot: Mammalian Sirtuins.

    Cell 159(4):956 (2014) PMID 25417168 PMCID PMC4337867

    The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-bind...
  9. Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal

    Cell (2014)

    Low energy states delay aging in multiple species, yet mechanisms coordinating energetics and longevity across tissues remain poorly defined. The conserved energy sensor AMP-activated protein kinase (AMPK) and its corresponding phosphatase calcineurin modulate longevity via the CREB re...
  10. Measurement of fatty acid oxidation rates in animal tissues and cell lines.

    Methods in Enzymology 542:391 (2014) PMID 24862277 PMCID PMC4154315

    While much oncological research has focused on metabolic shifts in glucose and amino acid oxidation, recent evidence suggests that fatty acid oxidation (FAO) may also play an important role in the metabolic reprogramming of cancer cells. Here, we present a simple method for measuring FAO rates u...
  11. Measurement of Fatty Acid Oxidation Rates in Animal Tissues and Cell Lines-Chapter Twenty

    Methods in Enzymology 542:391 (2014) PMID 24862277 PMCID PMC4154315

    While much oncological research has focused on metabolic shifts in glucose and amino acid oxidation, recent evidence suggests that fatty acid oxidation (FAO) may also play an important role in the metabolic reprogramming of cancer cells. Here, we present a simple method for measuring F...
  12. A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice.

    Hepatology 57(2):543 (2013) PMID 22941940

    Obesity is highly associated with dyslipidemia and cardiovascular disease. However, the mechanism behind this association is not completely understood. The hormone leptin may be a molecular link between obesity and dysregulation of lipid metabolism. Leptin can affect lipid metabolism independent...
  13. A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice.

    Hepatology 57(2):543 (2013) PMID 22941940

    Obesity is highly associated with dyslipidemia and cardiovascular disease. However, the mechanism behind this association is not completely understood. The hormone leptin may be a molecular link between obesity and dysregulation of lipid metabolism. Leptin can affect lipid metabolism independent...
  14. Adeno-associated Virus (AAV) for In Vivo a– and b– Cell Gene Delivery

    Canadian Journal of Diabetes 36(5):S62 (2012)

  15. Hepatic Leptin Signalling Modulates ApoB Containing Lipoprotein Size and Triglyceride Content

    Canadian Journal of Diabetes 36(5):S65 (2012)

  16. The role of leptin in glucose homeostasis.

    Journal Of Diabetes Investigation 3(2):115 (2012) PMID 24843554 PMCID PMC4020728

    The fat-derived hormone, leptin, is well known to regulate body weight. However, there is now substantial evidence that leptin also plays a primary role in the regulation of glucose homeostasis, independent of actions on food intake, energy expenditure or body weight. As such, leptin might have ...
  17. The role of leptin in glucose homeostasis.

    Journal Of Diabetes Investigation 3(2):115 (2012) PMID 24843554 PMCID PMC4020728

    The fat-derived hormone, leptin, is well known to regulate body weight. However, there is now substantial evidence that leptin also plays a primary role in the regulation of glucose homeostasis, independent of actions on food intake, energy expenditure or body weight. As such, leptin might have ...
  18. Acute disruption of leptin signaling in vivo leads to increased insulin levels and insulin resistance.

    Endocrinology 152(9):3385 (2011) PMID 21750049

    Leptin, an adipocyte-derived hormone, plays an essential role in the maintenance of normal body weight and energy expenditure, as well as glucose homeostasis. Indeed, leptin-deficient ob/ob mice are obese with profound hyperinsulinemia, insulin resistance, and often hyperglycemia. Interestingly,...
  19. Acute disruption of leptin signaling in vivo leads to increased insulin levels and insulin resistance.

    Endocrinology 152(9):3385 (2011) PMID 21750049

    Leptin, an adipocyte-derived hormone, plays an essential role in the maintenance of normal body weight and energy expenditure, as well as glucose homeostasis. Indeed, leptin-deficient ob/ob mice are obese with profound hyperinsulinemia, insulin resistance, and often hyperglycemia. Interestingly,...
  20. Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling.

    Diabetes 60(5):1414 (2011) PMID 21464443 PMCID PMC3292314

    Leptin therapy has been found to reverse hyperglycemia and prevent mortality in several rodent models of type 1 diabetes. Yet the mechanism of leptin-mediated reversal of hyperglycemia has not been fully defined. The liver is a key organ regulating glucose metabolism and is also a target of lept...