1. Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder.

    Journal of Neurophysiology 113(3):709 (2015) PMID 25376789 PMCID PMC4312873

    Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders are also characterized by sleep dysregulation, s...
  2. Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder.

    Journal of Neurophysiology 113(3):709 (2015) PMID 25376789 PMCID PMC4312873

    Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders are also characterized by sleep dysregulation, s...
  3. Differential Effects of Environment-Induced Changes in Body Temperature on Modafinil's Actions Against Methamphetamine-Induced Striatal Toxicity in Mice.

    Neurotoxicity Research 27(1):71 (2015) PMID 25261212

    Methamphetamine (METH) exposure can produce hyperthermia that might lead to toxicity and death. Modafinil is a wake-promoting compound that is also been prescribed off-label to treat METH dependence. Modafinil has shown neuroprotective properties against METH harmful effects in animal models. Th...
  4. Differential effects of environment-induced changes in body temperature on modafinil's actions against methamphetamine-induced striatal toxicity in mice.

    Neurotoxicity Research 27(1):71 (2015) PMID 25261212 PMCID PMC4482225

    Methamphetamine (METH) exposure can produce hyperthermia that might lead to toxicity and death. Modafinil is a wake-promoting compound that is also been prescribed off-label to treat METH dependence. Modafinil has shown neuroprotective properties against METH harmful effects in animal models. Th...
  5. Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice.

    Hearing Research 319:56 (2015) PMID 25481823

    CaV2.1 Ca(2+) channels play a key role in triggering neurotransmitter release and mediating synaptic transmission. Familial hemiplegic migraine type-1 (FHM-1) is caused by missense mutations in the CACNA1A gene that encodes the α1A pore-forming subunit of CaV2.1 Ca(2+) channels. We used knock-in...
  6. Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice.

    Hearing Research 319:56 (2015) PMID 25481823

    CaV2.1 Ca(2+) channels play a key role in triggering neurotransmitter release and mediating synaptic transmission. Familial hemiplegic migraine type-1 (FHM-1) is caused by missense mutations in the CACNA1A gene that encodes the α1A pore-forming subunit of CaV2.1 Ca(2+) channels. We used knock-in...
  7. Differential effects of environment-induced changes in body temperature on modafinil's actions against methamphetamine-induced striatal toxicity in mice.

    Neurotoxicity Research 27(1):71 (2015) PMID 25261212

    Methamphetamine (METH) exposure can produce hyperthermia that might lead to toxicity and death. Modafinil is a wake-promoting compound that is also been prescribed off-label to treat METH dependence. Modafinil has shown neuroprotective properties against METH harmful effects in animal models. Th...
  8. Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice.

    Neuropharmacology 87:188 (2014) PMID 24530829

    Chronic use of methamphetamine (METH) leads to long-lasting cognitive dysfunction in humans and in animal models. Modafinil is a wake-promoting compound approved for the treatment of sleeping disorders. It is also prescribed off label to treat METH dependence. In the present study, we investigat...
  9. Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice.

    Neuropharmacology 87:188 (2014) PMID 24530829

    Chronic use of methamphetamine (METH) leads to long-lasting cognitive dysfunction in humans and in animal models. Modafinil is a wake-promoting compound approved for the treatment of sleeping disorders. It is also prescribed off label to treat METH dependence. In the present study, we investigat...
  10. Water as solvent in the liquid-phase selective hydrogenation of crotonaldehyde to crotyl alcohol over Pt/ZnO: A factorial design approach

    Applied Catalysis B: Environmental 154-155:369 (2014)

  11. Water as solvent in the liquid-phase selective hydrogenation of crotonaldehyde to crotyl alcohol over Pt/ZnO: A factorial design approach

    Applied Catalysis B: Environmental 154-155:369 (2014)

  12. Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice.

    American Journal of Physiology - Cell Physiology 306(4):C396 (2014) PMID 24336653 PMCID PMC3919981

    Acid-sensing ion channels (ASIC) open in response to extracellular acidosis. ASIC1a, a particular subtype of these channels, has been described to have a postsynaptic distribution in the brain, being involved not only in ischemia and epilepsy, but also in fear and psychiatric pathologies. High-f...
  13. Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice.

    American Journal of Physiology - Cell Physiology 306(4):C396 (2014) PMID 24336653 PMCID PMC3919981

    Acid-sensing ion channels (ASIC) open in response to extracellular acidosis. ASIC1a, a particular subtype of these channels, has been described to have a postsynaptic distribution in the brain, being involved not only in ischemia and epilepsy, but also in fear and psychiatric pathologies. High-f...
  14. Pedunculopontine Nucleus Gamma Band Activity-Preconscious Awareness, Waking, and REM Sleep.

    Frontiers in Neurology 5:210 (2014) PMID 25368599 PMCID PMC4202729

    The pedunculopontine nucleus (PPN) is a major component of the reticular activating system (RAS) that regulates waking and REM sleep, states of high-frequency EEG activity. Recently, we described the presence of high threshold, voltage-dependent N- and P/Q-type calcium channels in RAS nuclei tha...
  15. Pedunculopontine Nucleus Gamma Band Activity-Preconscious Awareness, Waking, and REM Sleep.

    Frontiers in Neurology 5:210 (2014) PMID 25368599 PMCID PMC4202729

    The pedunculopontine nucleus (PPN) is a major component of the reticular activating system (RAS) that regulates waking and REM sleep, states of high-frequency EEG activity. Recently, we described the presence of high threshold, voltage-dependent N- and P/Q-type calcium channels in RAS nuclei tha...
  16. Spatiotemporal properties of high-speed calcium oscillations in the pedunculopontine nucleus.

    Journal of Applied Physiology 115(9):1402 (2013) PMID 23990242 PMCID PMC3841830

    The pedunculopontine nucleus (PPN) is a component of the reticular activating system (RAS), and is involved in the activated states of waking and rapid eye movement (REM) sleep. Gamma oscillations (approximately 30-80 Hz) are evident in all PPN neurons and are mediated by high-threshold voltage-...
  17. Spatiotemporal properties of high-speed calcium oscillations in the pedunculopontine nucleus.

    Journal of Applied Physiology 115(9):1402 (2013) PMID 23990242 PMCID PMC3841830

    The pedunculopontine nucleus (PPN) is a component of the reticular activating system (RAS), and is involved in the activated states of waking and rapid eye movement (REM) sleep. Gamma oscillations (approximately 30-80 Hz) are evident in all PPN neurons and are mediated by high-threshold voltage-...
  18. Role of G-proteins in the effects of leptin on pedunculopontine nucleus neurons.

    Journal of Neurochemistry 126(6):705 (2013) PMID 23692342 PMCID PMC3766503

    The pedunculopontine nucleus (PPN), the cholinergic arm of the reticular activating system, regulates waking and rapid eye movement sleep. Here, we demonstrate immunohistochemical labeling of the leptin receptor signaling isoform in PPN neurons, and investigated the effects of G-protein modulati...
  19. Visualization of fast calcium oscillations in the parafascicular nucleus.

    Pfluegers Archiv/European Journal of Physiology 465(9):1327 (2013) PMID 23588378 PMCID PMC3748156

    The parafascicular nucleus (Pf) is an ascending target of the pedunculopontine nucleus (PPN) and is part of the "non-specific" intralaminar thalamus. The PPN, part of the reticular activating system, is mainly involved in waking and rapid eye movement sleep. Gamma oscillations are evident in all...
  20. Role of G-proteins in the effects of leptin on pedunculopontine nucleus neurons.

    Journal of Neurochemistry 126(6):705 (2013) PMID 23692342 PMCID PMC3766503

    The pedunculopontine nucleus (PPN), the cholinergic arm of the reticular activating system, regulates waking and rapid eye movement sleep. Here, we demonstrate immunohistochemical labeling of the leptin receptor signaling isoform in PPN neurons, and investigated the effects of G-protein modulati...