Proteasome inhibitor PS-341 limits macrophage necroptosis by promoting cIAPs-mediated inhibition of RIP1 and RIP3 activation.
Biochemical and Biophysical Research Communicat... 477(4):761 (2016)
Apoptotic and necrotic macrophages have long been known for their existence in atherosclerotic lesions. However, the mechanisms underlying the choice of their death pattern have not been fully elucidated. Here, we report the effects of PS-341, a potent and specific proteasome inhibitor, on the c...
Meta-analysis of the association between four CAPN10 gene variants and gestational diabetes mellitus.
Archives of Gynecology and Obstetrics 294(3):447 (2016)
The purpose of the meta-analysis is to evaluate the association between calpain-10 (CANP10) gene polymorphisms and gestational diabetes mellitus (GDM).
A computer-based retrieval was performed in Web of Science, Embase and PubMed databases for eligible studies. The genotype data from four varian...
Selective Deposition of Silver Oxide on Single-Domain Ferroelectric Nanoplates and Their Efficient Visible-Light Photoactivity.
Chemistry: A European Journal 22(34):12160 (2016)
In this work, single-crystal and single-domain PbTiO3 nanoplates are employed as substrates to prepare Ag2 O/PbTiO3 composite materials through a photodeposition method. It is revealed that silver oxide nanocrystals with an average size of 63 nm are selectively deposited on the positive polar su...
Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms.
PNAS 113(31):E4558 (2016)
Bromodomain and extraterminal domain protein inhibitors (BETi) hold great promise as a novel class of cancer therapeutics. Because acquired resistance typically limits durable responses to targeted therapies, it is important to understand mechanisms by which tumor cells adapt to BETi. Here, thro...
Long-chain polyunsaturated fatty acid biosynthesis in the euryhaline herbivorous teleost Scatophagus argus: Functional characterization, tissue expression and nutritional regulation of two fatty acyl elongases.
Comparative Biochemistry and Physiology Part B:... 198:37 (2016)
Both the spotted scat Scatophagus argus and rabbitfish Siganus canaliculatus belong to the few cultured herbivorous marine teleost, however, their fatty acyl desaturase (Fad) system involved in long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis is different. The S. argus has a △6 Fad, ...
Three new oxazoline alkaloids from Gymnotheca chinensis.
Journal of Asian Natural Products Research 18(8):719 (2016)
Three novel oxazoline alkaloids, 1-oxa-3-azaspiro [4.5] dec-2-ene-8-one (1), 1-oxa-3-azaspiro [4.5] dec-2, 6-diene-8-one (2), and 1-oxa-3-azaspiro [4.5] dec-10-methoxy-2, 6-diene-8-one (3) were isolated from the methanol extract of the whole plant of Gymnotheca chinensis. The chemical structures...
Investigating axial diffusion in cylindrical pores using confocal single-particle fluorescence correlation spectroscopy.
Electrophoresis 37(15-16):2129 (2016)
We explored the feasibility of using confocal fluorescence correlation spectroscopy to study small nanoparticle diffusion in hundred-nanometer-sized cylindrical pores. By modeling single particle diffusion in tube-like confined three-dimensional space aligned parallel to the confocal optical axi...
Nanosecond Time-Resolution Study of Gold Nanorod Rotation at the Liquid-Solid Interface.
ChemPhysChem 17(14):2218 (2016)
Early studies showed that the adsorption of nanorods may start from a special "anchored" state, in which the nanorods lose translational motion but retain rotational freedom. Insight into how the anchored nanorods rotate should provide additional dimensions for understanding particle-surface int...
Measuring IL-6 and sIL-6R in serum from patients treated with tocilizumab and/or siltuximab following CAR T cell therapy.
Journal of Immunological Methods 434:1 (2016)
T cells expressing a CD19-specific chimeric antigen receptor (CAR19) are demonstrating remarkable efficacy in hematologic malignancies. Treatment is often associated with life-threatening cytokine release syndrome (CRS) which can be effectively treated with cytokine blockade using the antibodies...
Noninvasive prenatal testing (NIPT) in twin pregnancies with treatment of assisted reproductive techniques (ART) in a single center.
Prenatal Diagnosis 36(7):672 (2016)
The objective of the study is to report the performance of noninvasive prenatal testing (NIPT) in twin pregnancies after the treatment of assisted reproductive technology (ART).
In two years period, 565 pregnant women with ART twin pregnancies were prospectively tested by NIPT for screening for ...
Gradient shimming based on regularized estimation for B0-field and shim functions.
Mapping B0-field and shim functions spatially is a crucial step in the gradient shimming. The conventional estimation method used in the phase difference imaging technique takes no account for noise and T2(∗) effects, and is prone to create noisy and distorted field maps. This paper describes a ...
Esterification of Quercetin Increases Its Transport Across Human Caco-2 Cells.
Journal of Food Science 81(7):H1825 (2016)
Plant polyphenols showed useful biochemical characteristics in vitro; however, the assessments of their clinical applications in vivo are restricted by their limited bioavailability due to their strong resistance to 1st-pass effects during absorption. In order to improve the bioavailability of q...
Focal atrial tachycardia originating from the septal mitral annulus: electrocardiographic and electrophysiological characteristics and radiofrequency ablation.
Europace 18(7):1061 (2016)
This study sought to investigate electrocardiographic characteristics, electrophysiological features, and radiofrequency ablation in patients with focal atrial tachycardia (AT) originating from the septal mitral annulus.
In 13 patients with AT originating from the septal mitral annulus, activati...
Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor.
European Journal of Medicinal Chemistry 116:239 (2016)
c-Met/HGF overexpression has been detected in many human malignancies including tumors which are resistant to anticancer therapy. Disrupting the aberrant c-Met/HGF axis has enjoyed significant progress in both preclinical and clinical antitumor campaign. To eliminate the OCH2-related metabolic d...
Physical activity, sedentary behaviors and risk of gestational diabetes mellitus: a population-based cross-sectional study in Tianjin, China.
European Journal of Endocrinology 174(6):763 (2016)
Physical activity in a nonpregnant state or before pregnancy reduces the risk of type 2 diabetes and is also associated with reduced risk of gestational diabetes mellitus (GDM). However, it is uncertain whether physical activity during pregnancy reduces the risk of GDM.
Using an established univ...
An essential role of caffeoyl shikimate esterase in monolignol biosynthesis in Medicago truncatula.
Plant Journal 86(5):363 (2016)
Biochemical and genetic analyses have previously identified caffeoyl shikimate esterase (CSE) as an enzyme in the monolignol biosynthesis pathway in Arabidopsis thaliana, although the generality of this finding has been questioned. Here we show the presence of CSE genes and associated enzyme act...
Suppression of SIK1 by miR-141 in human ovarian cancer cell lines and tissues.
International Journal of Molecular Medicine 37(6):1601 (2016)
Epithelial ovarian cancer (EOC), the sixth most common cancer in women worldwide, is the most commonly fatal gynecologic malignancy in developed countries. One of the main reasons for this is that relatively little was known about the molecular events responsible for the development of this high...
Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.
Cancer Discovery 6(6):664 (2016)
Chimeric antigen receptor (CAR)-modified T cells with anti-CD19 specificity are a highly effective novel immune therapy for relapsed/refractory acute lymphoblastic leukemia. Cytokine release syndrome (CRS) is the most significant and life-threatening toxicity. To improve understanding of CRS, we...
The Importance of the Mean Platelet Aggregation Degree in Long-term Dual Antiplatelet Therapy Following Drug-Eluting Stent Implantation.
Cardiovascular Therapeutics 34(3):127 (2016)
The dual antiplatelet therapy (DAPT) and the response of clopidogrel were two pivotal issues in drug-eluting stent (DES) era.
To analyze the combined impacts of DAPT and the response to clopidogrel to evaluate their long-term effect on patients undergoing DES implantation.
Platelet aggregation w...
Microscopic Movement of Slow-Diffusing Nanoparticles in Cylindrical Nanopores Studied with Three-Dimensional Tracking.
Analytical chemistry 88(10):5122 (2016)
To study slow mass transport in confined environments, we developed a three-dimensional (3D) single-particle localization technique to track their microscopic movements in cylindrical nanopores. Under two model conditions, particles are retained much longer inside the pores: (1) increased solven...