1. Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients.

    International Journal of Inflammation 2015:734857 (2015) PMID 26064774 PMCID PMC4441988

    Introduction. Inflammation is ubiquitous during sepsis and may be influenced by body mass index (BMI). We sought to evaluate if BMI was associated with serum levels of several cytokines measured at intensive care unit admission due to sepsis. Methods. 33 septic patients were included. An array o...
  2. Septic Shock in Advanced Age: Transcriptome Analysis Reveals Altered Molecular Signatures in Neutrophil Granulocytes.

    PLoS ONE 10(6):e0128341 (2015) PMID 26047321 PMCID PMC4457834

    Sepsis is one of the highest causes of mortality in hospitalized people and a common complication in both surgical and clinical patients admitted to hospital for non-infectious reasons. Sepsis is especially common in older people and its incidence is likely to increase substantially as a populat...
  3. Increased intestinal production of α-defensins in aged rats with acute pancreatic injury.

    Experimental Gerontology 60:215 (2014) PMID 25449854

    Acute pancreatitis is a life-threatening situation, frequently associated with uncontrolled local and systemic inflammation, and aging is associated with a worst prognosis. Antimicrobial peptides are ancient molecules that belong to innate immunity, produced by epithelial and immune cells, and a...
  4. Increased intestinal production of α-defensins in aged rats with acute pancreatic injury

    Experimental Gerontology 60:215 (2014) PMID 25449854

    Acute pancreatitis is a life-threatening situation, frequently associated with uncontrolled local and systemic inflammation, and aging is associated with a worst prognosis. Antimicrobial peptides are ancient molecules that belong to innate immunity, produced by epithelial and immune ce...
  5. Increased intestinal production of α-defensins in aged rats with acute pancreatic injury.

    Experimental Gerontology 60:215 (2014) PMID 25449854

    Acute pancreatitis is a life-threatening situation, frequently associated with uncontrolled local and systemic inflammation, and aging is associated with a worst prognosis. Antimicrobial peptides are ancient molecules that belong to innate immunity, produced by epithelial and immune cells, and a...
  6. Increased intestinal production of α-defensins in aged rats with acute pancreatic injury

    Experimental Gerontology 60:215 (2014)

    Acute pancreatitis is a life-threatening situation, frequently associated with uncontrolled local and systemic inflammation, and aging is associated with a worst prognosis. Antimicrobial peptides are ancient molecules that belong to innate immunity, produced by epithelial and immune ce...
  7. Increased intestinal production of α-defensins in aged rats with acute pancreatic injury

    Experimental Gerontology 60:215 (2014)

    Acute pancreatitis is a life-threatening situation, frequently associated with uncontrolled local and systemic inflammation, and aging is associated with a worst prognosis. Antimicrobial peptides are ancient molecules that belong to innate immunity, produced by epithelial and immune ce...
  8. Increased intestinal production of α-defensins in aged rats with acute pancreatic injury

    Experimental Gerontology 60:215 (2014)

    Acute pancreatitis is a life-threatening situation, frequently associated with uncontrolled local and systemic inflammation, and aging is associated with a worst prognosis. Antimicrobial peptides are ancient molecules that belong to innate immunity, produced by epithelial and immune ce...
  9. Increased intestinal production of α-defensins in aged rats with acute pancreatic injury

    Experimental Gerontology 60:215 (2014)

    Acute pancreatitis is a life-threatening situation, frequently associated with uncontrolled local and systemic inflammation, and aging is associated with a worst prognosis. Antimicrobial peptides are ancient molecules that belong to innate immunity, produced by epithelial and immune ce...
  10. Beneficial effects of adenosine triphosphate-sensitive K(+) channel opener on liver ischemia/reperfusion injury.

    World Journal of Gastroenterology 20(41):15319 (2014) PMID 25386080 PMCID PMC4223265

    To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury. Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation. They were divided into 3 groups...
  11. Beneficial effects of adenosine triphosphate-sensitive K+ channel opener on liver ischemia/reperfusion injury.

    World Journal of Gastroenterology 20(41):15319 (2014) PMID 25386080 PMCID PMC4223265

    To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury. Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation. They were divided into 3 groups...
  12. Beneficial effects of adenosine triphosphate-sensitive K+ channel opener on liver ischemia/reperfusion injury.

    World Journal of Gastroenterology 20(41):15319 (2014) PMID 25386080 PMCID PMC4223265

    To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury. Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation. They were divided into 3 groups...
  13. Endotoxin tolerance drives neutrophil to infectious site.

    Shock 42(2):168 (2014) PMID 24667625

    The objective of this randomized animal study and laboratory investigation was to investigate whether lipopolysaccharide tolerance redirects neutrophil migration between organs. Male BALB/c mice received subcutaneous injections of lipopolysaccharide (1 mg/kg) for 5 days, followed by cecal ligati...
  14. Endotoxin tolerance drives neutrophil to infectious site.

    Shock 42(2):168 (2014) PMID 24667625

    The objective of this randomized animal study and laboratory investigation was to investigate whether lipopolysaccharide tolerance redirects neutrophil migration between organs. Male BALB/c mice received subcutaneous injections of lipopolysaccharide (1 mg/kg) for 5 days, followed by cecal ligati...
  15. Endotoxin tolerance drives neutrophil to infectious site.

    Shock 42(2):168 (2014) PMID 24667625

    The objective of this randomized animal study and laboratory investigation was to investigate whether lipopolysaccharide tolerance redirects neutrophil migration between organs. Male BALB/c mice received subcutaneous injections of lipopolysaccharide (1 mg/kg) for 5 days, followed by cecal ligati...
  16. Neuropeptide downregulation in sepsis.

    Inflammation 37(1):142 (2014) PMID 24005899

    Neuropeptides are an extremely conserved arm of neurobiology. Despite their effects as neurohormones and neurotransmitters, a multitude of other effects have been described, putting in evidence their importance as regulators of immune responses, such as chemotaxis, oxidative burst, pro-inflammat...
  17. Neuropeptide downregulation in sepsis.

    Inflammation 37(1):142 (2014) PMID 24005899

    Neuropeptides are an extremely conserved arm of neurobiology. Despite their effects as neurohormones and neurotransmitters, a multitude of other effects have been described, putting in evidence their importance as regulators of immune responses, such as chemotaxis, oxidative burst, pro-inflammat...
  18. sRAGE in septic shock: a potential biomarker of mortality.

    Revista brasileira de terapia intensiva 26(4):392 (2014) PMID 25607269 PMCID PMC4304468

    To evaluate and understand the clinical implications of the plasma levels of a soluble isoform of a receptor for advanced glycation end products (sRAGE) in different stages of sepsis. Serum sRAGE values in patients who were divided into intensive care unit control, severe sepsis, septic shock an...
  19. Relationship between acid-base status and inflammation in the critically ill.

    Critical care (London, England) 18(4):R154 (2014) PMID 25034180 PMCID PMC4223545

    There is a complex interplay between changes in acid-base components and inflammation. This manuscript aims to explore associations between plasma cytokines and chemokines and acid-base status on admission to intensive care. We conducted a prospective cohort study in a 13-bed ICU in a tertiary-c...
  20. Hyperammonemia due to urea cycle disorders: a potentially fatal condition in the intensive care setting.

    Journal of intensive care 2(1):22 (2014) PMID 25908985 PMCID PMC4407289

    Disorders of the urea cycle are secondary to a defect in the system that converts ammonia into urea, resulting in accumulation of ammonia and other products. This results in encephalopathy, coma, and death if not recognized and treated rapidly. Late-onset urea cycle disorders may be precipitated...