1. Master molecule, heal thyself.

    Journal of Biological Chemistry 289(20):13691 (2014) PMID 24711456 PMCID PMC4022841

  2. Master molecule, heal thyself.

    Journal of Biological Chemistry 289(20):13691 (2014) PMID 24711456 PMCID PMC4022841

  3. Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.

    Nucleic Acids Research 41(22):10312 (2013) PMID 24038355 PMCID PMC3905884

    Translesion DNA synthesis (TLS) can use specialized DNA polymerases to insert and/or extend nucleotides across lesions, thereby limiting stalled replication fork collapse and the potential for cell death. Recent studies have shown that monoubiquitinated proliferating cell nuclear antigen (PCNA) ...
  4. Increased dietary cholesterol promotes enhanced mutagenesis in DNA polymerase kappa-deficient mice.

    DNA Repair 12(10):817 (2013) PMID 23948094

    DNA polymerase kappa (Polκ) bypasses planar polycyclic N2-guanine adducts in an error-free manner. Cholesterol derivatives may interact with DNA to form similarly bulky lesions. In accordance, these studies examined whether increased mutagenesis of DNA accompanies hypercholesterolemia in Polk-/-...
  5. A life of fixing DNA.

    DNA Repair 12(6):389 (2013) PMID 23828963

  6. A life of fixing DNA.

    DNA Repair 12(6):389 (2013) PMID 23828963

  7. Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks.

    DNA Repair 12(5):377 (2013) PMID 23522793 PMCID PMC3636179

    The Y-family of DNA polymerases support of translesion DNA synthesis (TLS) associated with stalled DNA replication by DNA damage. Recently, a number of studies suggest that some specialized TLS polymerases also support other aspects of DNA metabolism beyond TLS in vivo. Here we show that mouse p...
  8. Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks.

    DNA Repair 12(5):377 (2013) PMID 23522793 PMCID PMC3636179

    The Y-family of DNA polymerases support of translesion DNA synthesis (TLS) associated with stalled DNA replication by DNA damage. Recently, a number of studies suggest that some specialized TLS polymerases also support other aspects of DNA metabolism beyond TLS in vivo. Here we show that mouse p...
  9. Happy 10th birthday.

    DNA Repair 11(1):2 (2012) PMID 22226012

  10. Autobiographical series.

    DNA Repair 10(8):800 (2011) PMID 21798466

  11. Nucleotide excision repair of DNA: The very early history.

    DNA Repair 10(7):668 (2011) PMID 21600859

    This article, taken largely from the book Correcting the Blueprint of Life: An Historical Account of the Discovery of DNA Repair Mechanisms, summarizes the very early history of the discovery of nucleotide excision repair. Copyright © 2011 Elsevier B.V. All rights reserved.
  12. Supplementary information in published manuscripts.

    DNA Repair 10(1):2 (2011) PMID 21112818

  13. Peer review of scientific papers--a never-ending conundrum.

    DNA Repair 9(5):476 (2010) PMID 20378420

  14. A comprehensive catalogue of somatic mutations in cancer genomes.

    DNA Repair 9(4):468 (2010) PMID 20181537

    This Hot Topics contribution considers two recently published papers that demonstrate the utility of advanced DNA sequencing technologies for identifying classes of mutations other than base substitutions. Data are presented from genome analyses of immortalized cell lines derived from a malignan...
  15. SnapShot: nucleotide excision repair.

    Cell 140(5):754 (2010) PMID 20211143

  16. Good news on the horizon: the Open Researcher and Contributor ID (ORCID).

    DNA Repair 9(2):102 (2010) PMID 20083443

  17. Polk mutant mice have a spontaneous mutator phenotype.

    DNA Repair 8(12):1355 (2009) PMID 19783230 PMCID PMC2787749

    Mice defective for the Polk gene, which encodes DNA polymerase kappa, are viable and do not manifest obvious phenotypes. The present studies document a spontaneous mutator phenotype in Polk(-/-) mice. The initial indication of enhanced spontaneous mutations in these mice came from the serendipit...
  18. Rad10 exhibits lesion-dependent genetic requirements for recruitment to DNA double-strand breaks in Saccharomyces cerevisiae.

    Nucleic Acids Research 37(19):6429 (2009) PMID 19729509 PMCID PMC2770674

    In the yeast Saccharomyces cerevisiae, the Rad1-Rad10 protein complex participates in nucleotide excision repair (NER) and homologous recombination (HR). During HR, the Rad1-Rad10 endonuclease cleaves 3' branches of DNA and aberrant 3' DNA ends that are refractory to other 3' processing enzymes....
  19. Y-family DNA polymerases in mammalian cells.

    Experientia. Basel 66(14):2363 (2009) PMID 19367366

    Eukaryotic genomes are replicated with high fidelity to assure the faithful transmission of genetic information from one generation to the next. The accuracy of replication relies heavily on the ability of replicative DNA polymerases to efficiently select correct nucleotides for the polymerizati...
  20. Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice.

    Free Radical Biology and Medicine 46(11):1488 (2009) PMID 19268524 PMCID PMC2677124

    Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is the redox regulator of multiple stress-inducible transcription factors, such as NF-kappaB, and the major 5'-endonuclease in base excision repair (BER). We utilized mice containing a heterozygous gene-targeted deletion of APE1/Re...