Absence of FcγRIII results in increased proinflammatory response in FcγRIII-KO cardiac recipients.
Transplantation 96(7):601 (2013)
Alloantibody can contribute significantly to rejection of heart transplants by activation of complement and interactions with a variety of effector cells, including macrophages and monocytes through activating FcγRI, FcγRIII, FcγRIV, the inhibitory FcγRIIB and complement receptors. These recepto...
The involvement of FcR mechanisms in antibody-mediated rejection.
Transplantation 84(10):1324 (2007)
Antibody-mediated rejection is characterized by macrophage margination against vascular endothelium. The potential interactions triggered by antibodies between endothelial cells (EC) and macrophages have not been examined thoroughly in transplants. We used in vivo and in vitro models of antibody...
B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates.
Nature Medicine 13(11):1295 (2007)
We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitutio...
Antibody-induced transplantation tolerance that is dependent on thymus-derived regulatory T cells.
Journal of Immunology 176(5):2799 (2006)
Targeting of the CD45RB isoform by mAb (anti-CD45RB) effectively induces donor-specific tolerance to allografts. The immunological mechanisms underlying the tolerant state remain unclear although some studies have suggested the involvement of regulatory T cells (T-regs). Although their generativ...
Evidence for a critical T cell - B cell interaction in tolerance induced by anti-CD45RB
Journal of the American College of Surgeons 201(3):S92 (2005)
Expanded-criteria donor kidneys: a single-center clinical and short-term financial analysis--cause for concern in retransplantation.
Transplantation 78(11):1670 (2004)
Expanded-criteria donor (ECD) kidneys are associated with a higher risk of posttransplant failure, but they remain a favorable alternative to dialysis. Now that a uniform definition of "expanded criteria" exists, it is more appropriate than ever to evaluate their utility compared with that seen ...
Transplantation for type I diabetes: comparison of vascularized whole-organ pancreas with isolated pancreatic islets.
Annals of Surgery 240(4):631 (2004)
We sought to compare the efficacy, risks, and costs of whole-organ pancreas transplantation (WOP) with the costs of isolated islet transplantation (IIT) in the treatment of patients with type I diabetes mellitus.
A striking improvement has taken place in the results of IIT with regard to attaini...
Factors differentially correlated with the outcome of liver transplantation in hcv+ and HCV- recipients.
Transplantation 77(12):1834 (2004)
Survival following liver transplantation for hepatitis C virus (HCV) is significantly poorer than for liver transplants performed for other causes of chronic liver disease. The factors responsible for the inferior outcome in HCV+ recipients, and whether they differ from factors associated with s...
Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects.
Diabetes 53(3):624 (2004)
Type 2 diabetic subjects manifest both disordered insulin action and abnormalities in their pancreatic islet cells. Whether the latter represents a primary defect or is a consequence of the former is unknown. To examine the beta-cell mass and function of islets from type 2 diabetic patients dire...
Early kidney dysfunction post liver transplantation predicts late chronic kidney disease.
Transplantation 77(4):553 (2004)
Acute and chronic renal dysfunction (ARD, CRD) are common complications after liver transplantation and are associated with poor outcome.
We reviewed the results of 181 liver transplants performed in our institution between January 1, 1998 and December 31, 2000 in which the recipients were alive...
Predicting outcome after liver transplantation: utility of the model for end-stage liver disease and a newly derived discrimination function.
Transplantation 77(1):99 (2004)
The Model for End-Stage Liver Disease (MELD) has been found to accurately predict pretransplant mortality and is a valuable system for ranking patients in greatest need of liver transplantation. It is unknown whether a higher MELD score also predicts decreased posttransplant survival.
The use of non-heart-beating donors for isolated pancreatic islet transplantation.
Transplantation 75(9):1423 (2003)
Recent improvements in isolated islet transplantation indicate that this therapy may ultimately prove applicable to patients with type I diabetes. An obstacle preventing widespread application of islet transplantation is an insufficient supply of cadaveric pancreata. Non-heart-beating donors (NH...
Vulnerability of allografts to rejection by MHC class II-restricted T-cell receptor transgenic mice.
Transplantation 75(8):1415 (2003)
Examination of the in vivo activation and function of CD4+ T cells in response to allografts may advance our understanding of the rejection process. We analyzed the capacity of transgenic class II-restricted CD4 T cells to reject skin, cardiac, and islet transplants.
TS1 mice possess a high freq...
122:Investigation of Non-Heart Beating Donors as a Potential Source of Pancreatic Islets
Journal of Gastrointestinal Surgery 7(2):295 (2003)
Comparison of open, laparoscopic, and hand-assisted approaches to live-donor nephrectomy.
Transplantation 74(2):169 (2002)
Minimally invasive donor nephrectomy has become a favored procedure for the procurement of kidneys from live donors. The optimal minimally invasive surgical approach has not been determined. In the current work, we compared the outcome of kidneys procured using the traditional open approach with...
The outcome of liver grafts procured from hepatitis C-positive donors.
Transplantation 73(4):582 (2002)
The growing prevalence of hepatitis C virus (HCV) infection in the general population has resulted in an increased frequency of potential organ donors that carry the virus. The survival of grafts from HCV+ donors has not been studied in detail.
Two study populations were examined retrospectively...