Foxp3 processing by proprotein convertases and control of regulatory T cell function.
Journal of Biological Chemistry 284(9):5709 (2009)
Foxp3 is a 47-kDa transcription factor central to regulatory T cell (Treg) function. The importance of Foxp3(+) Tregs in controlling self-reactive T cells and preventing autoimmunity is well established. Our analysis of Foxp3 expression in natural Tregs led to identification of a shorter 41-kDa ...
Three distinct domains contribute to nuclear transport of murine Foxp3.
PLoS ONE 4(11):e7890 (2009)
Foxp3, a 47-kDa transcription factor, is necessary for the function of CD4+CD25+ regulatory T cells (Tregs), with an essential role in the control of self-reactive T cells and in preventing autoimmunity. Activation of Tregs by TCR engagement results in upregulation of Foxp3 expression, followed ...
Deacetylase inhibition promotes the generation and function of regulatory T cells.
Nature Medicine 13(11):1299 (2007)
Histone/protein deacetylases (HDACs) regulate chromatin remodeling and gene expression as well as the functions of more than 50 transcription factors and nonhistone proteins. We found that administration of an HDAC inhibitor (HDACi) in vivo increased Foxp3 gene expression, as well as the product...
Histone deacetylase inhibitors and transplantation.
Current Opinion in Immunology 19(5):589 (2007)
Simply detecting the presence or absence of Foxp3, a transcription factor characteristic of naturally occurring CD4+ CD25+ regulatory T cells (Tregs), now appears of minimal value in predicting the outcome of immunologic responses, since dividing human CD4+ effector T cells can induce Foxp3 with...
Alloimmunity in primate heart recipients with CD154 blockade: evidence for alternative costimulation mechanisms.
Transplantation 81(2):255 (2006)
CD154 mediates key facets of humoral and cellular immunity to alloantigens, and is tolerogenic to influenza antigens in primates. Barriers to CD154-based tolerance induction for primate cardiac allografts have not previously been defined.
Heterotopic cardiac allograft outcomes in cynomolgus monk...
Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice.
Transplantation 79(9):1091 (2005)
Type 1 diabetes results from auto-aggressive T-cell-mediated destruction of beta cells of the pancreas. Recent data suggest that restoration of self-tolerance may facilitate islet-cell regeneration/recovery. In view of the immunoregulatory activity of transforming growth factor (TGF)-beta1, we i...
Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor.
Journal of Experimental Medicine 201(7):1037 (2005)
Although certain chemokines and their receptors guide homeostatic recirculation of T cells and others promote recruitment of activated T cells to inflammatory sites, little is known of the mechanisms underlying a third function, migration of Foxp3(+) regulatory T (T reg) cells to sites where the...
Disruption of the ICOS-B7RP-1 costimulatory pathway leads to enhanced hepatic immunopathology and increased gamma interferon production by CD4 T cells in murine schistosomiasis.
Infection and Immunity 71(7):4040 (2003)
Morbidity and mortality in schistosomiasis are largely due to an immune response mediated by CD4 T lymphocytes. Since lymphocyte activation is shaped by costimulatory signals, the specific functions of different costimulatory pathways are of increasing interest. We now examined the role of the i...
Programmed death-1 targeting can promote allograft survival.
Journal of Immunology 169(11):6546 (2002)
The recently identified CD28 homolog and costimulatory molecule programmed death-1 (PD-1) and its ligands, PD-L1 and PD-L2, which are homologs of B7, constitute an inhibitory regulatory pathway of potential therapeutic use in immune-mediated diseases. We examined the expression and functions of ...
The 5′ Flanking Region of the Human Bone Morphogenetic Protein-7 Gene
Biochemical and Biophysical Research Communicat... 282(3):823 (2001)
We describe here the cloning and characterization of the 5′ flanking region of the human Bone Morphogenetic Protein-7 (BMP-7) gene from a 3.3 kb genomic DNA fragment. Functional analysis by transient transfection using the luciferase reporter gene indicated that this region had a low b...
Osteogenic Protein-1 mRNA in the Uterine Endometrium
Biochemical and Biophysical Research Communicat... 234(1):242 (1997)
OP-1, a bone morphogenetic protein (BMP) in the TGF-β superfamily, is expressed at high levels in the kidney and in the endometrium of the uterus of non-pregnant mice. During pregnancy the OP-1 mRNA in the endometrium rapidly declined at 4 dpc. Thereafter, OP-1 transcripts were detected in ...
Murine osteogenic protein (OP-1): High levels of mRNA in kidney
Biochemical and Biophysical Research Communicat... 179(1):116 (1991)
The murine OP-1 gene (EMBL accession No. X56906) encoding the homolog of human osteogenic protein-1 was isolated from cDNA and genomic libraries using human OP-1 cDNA as probe. The deduced murine OP-1 amino acid sequence revealed 11 amino acids changes, three of them in the mature protein. ...
The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses
Cell 48(6):1035 (1987)
Conjugation of ubiquitin to intracellular proteins mediates their selective degradation in eukaryotes. In the yeast Saccharomyces cerevisiae, four distinct ubiquitin-coding loci have been described.
UBI3 each encode hybrid proteins in which ubiquitin is ...