1. Enterohaemorrhagic Escherichia coli requires the spectrin cytoskeleton for efficient attachment and pedestal formation on host cells.

    Microbial Pathogenesis 52(3):149 (2012) PMID 22197999

    Recent work has demonstrated that the spectrin cytoskeleton is a host cell target, exploited during intestinal bacterial disease. Here we show that the highly virulent intestinal pathogen enterohaemorrhagic Escherichia coli (EHEC) is also reliant upon the spectrin cytoskeleton during key pathoge...
  2. EnterohaemorrhagicEscherichia colirequires the spectrin cytoskeleton for efficient attachment and pedestal formation on host cells

    Microbial Pathogenesis 52(3):149 (2012)

    Recent work has demonstrated that the spectrin cytoskeleton is a host cell target, exploited during intestinal bacterial disease. Here we show that the highly virulent intestinal pathogen enterohaemorrhagic Escherichia coli (EHEC) is also reliant upon the spectrin cytoskeleton during k...
  3. Cortical mechanisms of visual context processing in singleton search.

    Neuroscience Letters 502(1):46 (2011) PMID 21802495

    When searching for a target object presented in a context of other, irrelevant objects, the dissimilarity between target and surrounding context elements as well as the similarity between context elements themselves affect search efficiency. The present functional imaging study explored the cort...
  4. Francisella tularensis uses cholesterol and clathrin-based endocytic mechanisms to invade hepatocytes.

    Scientific reports 1:192 (2011) PMID 22355707 PMCID PMC3240981

    Francisella tularensis are highly infectious microbes that cause the disease tularemia. Although much of the bacterial burden is carried in non-phagocytic cells, the strategies these pathogens use to invade these cells remains elusive. To examine these mechanisms we developed two in vitro Franci...
  5. Distraction and target selection in the brain: an fMRI study.

    Neuropsychologia 48(11):3335 (2010) PMID 20654634

    To attend successfully, a specification of what is currently relevant is necessary, but not sufficient. Irrelevant stimuli that are also present in the environment must be recognized as such and filtered out at the same time. Using functional magnetic resonance imaging, we showed that posterior ...
  6. Hijacking the endocytic machinery by microbial pathogens.

    Protoplasma 244(1-4):75 (2010) PMID 20574860

    Understanding the mechanisms that microbes exploit to invade host cells and cause disease is crucial if we are to eliminate their threat. Although pathogens use a variety of microbial factors to trigger entry into non-phagocytic cells, their targeting of the host cell process of endocytosis has ...
  7. Gap junction hemichannels contribute to the generation of diarrhoea during infectious enteric disease.

    Gut 59(2):218 (2010) PMID 19828465

    The attaching and effacing (A/E) pathogens enterohaemorrhagic Escherichia coli, enteropathogenic E coli and Citrobacter rodentium colonise intestinal tracts, attach to enterocytes, collapse infected cell microvilli and alter numerous host cell processes during infection. Enterocyte alterations r...
  8. Distraction and target selection in the brain: An fMRI study

    Neuropsychologia 48(11):3335 (2010)

    To attend successfully, a specification of what is currently relevant is necessary, but not sufficient. Irrelevant stimuli that are also present in the environment must be recognized as such and filtered out at the same time. Using functional magnetic resonance imaging, we showed that poste...
  9. Comparing glaucomatous optic neuropathy in primary open angle and primary angle closure glaucoma eyes by scanning laser polarimetry-variable corneal compensation.

    Journal of Glaucoma 17(2):105 (2008) PMID 18344755

    To study the retinal nerve fiber layer thickness difference between high-tension primary open angle glaucoma (HT-POAG) and primary angle closure glaucoma (PACG) eyes using scanning laser polarimetry-variable corneal compensation (GDx VCC) in Taiwan-Chinese population; to evaluate the usefulness ...
  10. Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

    Nature Medicine 13(11):1333 (2007) PMID 17982462

    Anorexia and weight loss are part of the wasting syndrome of late-stage cancer, are a major cause of morbidity and mortality in cancer, and are thought to be cytokine mediated. Macrophage inhibitory cytokine-1 (MIC-1) is produced by many cancers. Examination of sera from individuals with advance...
  11. The -251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopathology in Chinese population.

    Clinical Cancer Research 11(18):6431 (2005) PMID 16166417

    Persistent interleukin-8 (IL-8) production contributes to chronic inflammation of the stomach. The proinflammatory IL-1beta polymorphisms, which enhance the cytokine production, are associated with increased risk of gastric cancer. The -251A/T polymorphism of the IL-8 promoter is involved in sev...