1. Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.

    Neuroscience & Biobehavioral Reviews 55:333 (2015) PMID 25999120 PMCID PMC4501875

    Many psychiatric illnesses are associated with early mortality and with an increased risk of developing physical diseases that are more typically seen in the elderly. Moreover, certain psychiatric illnesses may be associated with accelerated cellular aging, evidenced by shortened leukocyte telom...
  2. Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999-2002.

    Epidemiology 26(4):528 (2015) PMID 26039272

    This study examined the association between leukocyte telomere length--a marker of cell aging--and mortality in a nationally representative sample of US adults ages 50-84 years. We also examined moderating effects of age, sex, race/ethnicity, and education. Data were from the National Health and...
  3. Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample.

    Journal of Health and Social Behavior 56(2):199 (2015) PMID 25930147

    Residents of distressed urban areas suffer early aging-related disease and excess mortality. Using a community-based participatory research approach in a collaboration between social researchers and cellular biologists, we collected a unique data set of 239 black, white, or Mexican adults from a...
  4. PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression.

    Psychiatry Research 232(1):58 (2015) PMID 25773002 PMCID PMC4404215

    Accelerated cell aging, indexed in peripheral leukocytes by telomere shortness and in peripheral blood mononuclear cells (PBMCs) by telomerase activity, has been reported in several studies of major depressive disorder (MDD). However, the relevance of these peripheral measures for brain indices ...
  5. Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

    Cell 160(5):928 (2015)

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cyc...
  6. Early telomerase inactivation accelerates aging independently of telomere length.

    Cell 160(5):928 (2015) PMID 25723167

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cycle dynamic...
  7. Early telomerase inactivation accelerates aging independently of telomere length.

    Cell 160(5):928 (2015) PMID 25723167 PMCID PMC4496004

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cycle dynamic...
  8. Associations of cadmium and lead exposure with leukocyte telomere length: findings from National Health and Nutrition Examination Survey, 1999-2002.

    American Journal of Epidemiology 181(2):127 (2015) PMID 25504027 PMCID PMC4351349

    Cadmium and lead are ubiquitous environmental contaminants that might increase risks of cardiovascular disease and other aging-related diseases, but their relationships with leukocyte telomere length (LTL), a marker of cellular aging, are poorly understood. In experimental studies, they have bee...
  9. Associations of cadmium and lead exposure with leukocyte telomere length: findings from National Health and Nutrition Examination Survey, 1999-2002.

    American Journal of Epidemiology 181(2):127 (2015) PMID 25504027 PMCID PMC4351349

    Cadmium and lead are ubiquitous environmental contaminants that might increase risks of cardiovascular disease and other aging-related diseases, but their relationships with leukocyte telomere length (LTL), a marker of cellular aging, are poorly understood. In experimental studies, they have bee...
  10. Maternal estriol concentrations in early gestation predict infant telomere length.

    Journal of Clinical Endocrinology & Metabolism 100(1):267 (2015) PMID 25337925

    Telomere biology plays a fundamental role in genomic integrity, cellular regeneration, physiology, aging, disease risk, and mortality. The initial setting of telomere length (TL) in early life has important implications for telomere maintenance and related disorders throughout the life span. How...
  11. Maternal estriol concentrations in early gestation predict infant telomere length.

    Journal of Clinical Endocrinology & Metabolism 100(1):267 (2015) PMID 25337925 PMCID PMC4283015

    Telomere biology plays a fundamental role in genomic integrity, cellular regeneration, physiology, aging, disease risk, and mortality. The initial setting of telomere length (TL) in early life has important implications for telomere maintenance and related disorders throughout the life span. How...
  12. Maternal estriol concentrations in early gestation predict infant telomere length.

    Journal of Clinical Endocrinology & Metabolism 100(1):267 (2015) PMID 25337925 PMCID PMC4283015

    Telomere biology plays a fundamental role in genomic integrity, cellular regeneration, physiology, aging, disease risk, and mortality. The initial setting of telomere length (TL) in early life has important implications for telomere maintenance and related disorders throughout the life span. How...
  13. Maternal estriol concentrations in early gestation predict infant telomere length.

    Journal of Clinical Endocrinology & Metabolism 100(1):267 (2015) PMID 25337925 PMCID PMC4283015

    Telomere biology plays a fundamental role in genomic integrity, cellular regeneration, physiology, aging, disease risk, and mortality. The initial setting of telomere length (TL) in early life has important implications for telomere maintenance and related disorders throughout the life span. How...
  14. An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity.

    Blood 124(25):3675 (2014) PMID 25320237 PMCID PMC4263978

    Telomerase is a ribonucleoprotein complex that adds telomeric DNA to the ends of linear chromosomes. It contains two core canonical components: the essential RNA component, hTR, which provides the template for DNA synthesis, and the reverse transcriptase protein component, hTERT. Low telomerase ...
  15. An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity.

    Blood 124(25):3675 (2014) PMID 25320237 PMCID PMC4263978

    Telomerase is a ribonucleoprotein complex that adds telomeric DNA to the ends of linear chromosomes. It contains two core canonical components: the essential RNA component, hTR, which provides the template for DNA synthesis, and the reverse transcriptase protein component, hTERT. Low telomerase ...
  16. An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity.

    Blood 124(25):3675 (2014) PMID 25320237 PMCID PMC4263978

    Telomerase is a ribonucleoprotein complex that adds telomeric DNA to the ends of linear chromosomes. It contains two core canonical components: the essential RNA component, hTR, which provides the template for DNA synthesis, and the reverse transcriptase protein component, hTERT. Low telomerase ...
  17. An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity.

    Blood 124(25):3675 (2014) PMID 25320237 PMCID PMC4263978

    Telomerase is a ribonucleoprotein complex that adds telomeric DNA to the ends of linear chromosomes. It contains two core canonical components: the essential RNA component, hTR, which provides the template for DNA synthesis, and the reverse transcriptase protein component, hTERT. Low telomerase ...
  18. An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity.

    Blood 124(25):3675 (2014) PMID 25320237

    Telomerase is a ribonucleoprotein complex that adds telomeric DNA to the ends of linear chromosomes. It contains two core canonical components: the essential RNA component, hTR, which provides the template for DNA synthesis, and the reverse transcriptase protein component, hTERT. Low telomerase ...
  19. An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity.

    Blood 124(25):3675 (2014) PMID 25320237 PMCID PMC4263978

    Telomerase is a ribonucleoprotein complex that adds telomeric DNA to the ends of linear chromosomes. It contains two core canonical components: the essential RNA component, hTR, which provides the template for DNA synthesis, and the reverse transcriptase protein component, hTERT. Low telomerase ...
  20. Telomere length and the risk of atrial fibrillation: insights into the role of biological versus chronological aging.

    Circulation: Arrhythmia and Electrophysiology 7(6):1026 (2014) PMID 25381796 PMCID PMC4294941

    Advanced age is the most important risk factor for atrial fibrillation (AF); however, the mechanism remains unknown. Telomeres, regions of DNA that shorten with cell division, are considered reliable markers of biological aging. We sought to examine the association between leukocyte telomere len...