Fatal spontaneous Clostridium septicum gas gangrene: a possible association with iatrogenic gastric acid suppression.
Archives of Pathology & Laboratory Medicine 138(6):837 (2014)
The long-term use of proton pump inhibitors has been linked to an increased risk for the development of gastric polyps, hip fractures, pneumonia, and Clostridium difficile colitis. There is evidence that chronic acid suppression from long-term use of proton pump inhibitors poses some risk for th...
Fetal death resulting from an isolated congenital partial pericardial defect.
Obstetrics & Gynecology 123(2 Pt 2 Suppl 2):443 (2014)
Congenital pericardial defects occur from a defect in the formation of the pleuropericardial membrane during embryonic development. This defect may be asymptomatic but can be fatal if complicated by herniation of any portion of the heart.
We report two cases in which herniation of a portion of t...
Defects in laterality with emphasis on heterotaxy syndromes with asplenia and polysplenia: an autopsy case series at a single institution.
Pediatric and Developmental Pathology 17(4):250 (2014)
Heterotaxy is a rare disease with high morbidity and mortality. Controversy exists over how to classify these syndromes with most cases stratified into asplenia/polysplenia syndromes or right/left isomerism. In an effort to review comprehensively specific pheonotypes associated with heterotaxy s...
To image or to autopsy?
Annals of Internal Medicine 156(2):158 (2012)
AIRP best cases in radiologic-pathologic correlation: cerebral fat embolism syndrome in sickle cell β-thalassemia.
RadioGraphics 32(5):1301 (2012)
Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation.
Journal of Experimental Medicine 208(3):479 (2011)
The human breast tumor microenvironment can display features of T helper type 2 (Th2) inflammation, and Th2 inflammation can promote tumor development. However, the molecular and cellular mechanisms contributing to Th2 inflammation in breast tumors remain unclear. Here, we show that human breast...
Carcinoid heart disease without the carcinoid syndrome but with quadrivalvular regurgitation and unsuccessful operative intervention.
The American Journal of Cardiology 107(5):788 (2011)
A 53-year-old woman is described who underwent mitral and aortic valve replacement and tricuspid valve annuloplasty for pure regurgitation at all 3 valve sites for unrecognized carcinoid heart disease without the carcinoid syndrome 22 days before death. Metastatic carcinoid was not recognized un...
Embedding measurement within existing computerized data systems: scaling clinical laboratory and medical records heart failure data to predict ICU admission.
Journal of applied measurement 11(3):271 (2010)
This study employs existing data sources to develop a new measure of intensive care unit (ICU) admission risk for heart failure patients. Outcome measures were constructed from laboratory, accounting, and medical record data for 973 adult inpatients with primary or secondary heart failure. Sever...
Full blown cardiovascular syphilis with aneurysm of the innominate artery.
The American Journal of Cardiology 104(11):1595 (2009)
The investigators report the case of a 44-year-old man who presented acutely and was found to have saccular aneurysm of the innominate artery, narrowed or totally occluded aortic arch arteries, and marked thickening of the thoracic aorta except for the wall behind the sinuses of Valsalva. The ab...
Diagnosing cardiac sarcoidosis clinically without tissue confirmation.
Proceedings (Baylor University. Medical Center) 22(3):236 (2009)
A 52-year-old woman is described in whom cardiac sarcoidosis was diagnosed clinically on the basis of high-grade heart block, recurring ventricular tachyarrhythmias, and acute cardiac decompensation. Confirmation of sarcoidosis was not determined until necropsy. When it causes cardiac dysfunctio...
Pathologic findings in larval and juvenile anurans inhabiting farm ponds in Tennessee, USA.
Journal of Wildlife Diseases 45(2):314 (2009)
Amphibian populations are declining globally, yet general pathologic surveys for free-ranging amphibians are uncommon. Pathologic surveys are necessary to provide insight into the impacts of humans on emergence of pathogens in amphibian populations. During 2005, 104 American bullfrog (Rana cates...
Disseminated toxoplasmosis in a patient with undiagnosed AIDS.
Proceedings (Baylor University. Medical Center) 22(1):20 (2009)
Approximately 60% of deaths in patients with AIDS are a direct result of infection other than HIV. The more severe and life-threatening complications of HIV infection occur in patients with a CD4(+) T cell count <200 cells/μL. In the absence of effective retroviral therapy, these infections are ...
Pulmonary invasive mucormycosis in a patient with secondary iron overload following deferoxamine therapy.
Proceedings (Baylor University. Medical Center) 21(4):378 (2008)
Mucormycosis (zygomycosis) is an acute and often fatal opportunistic fungal infection. Predisposing factors in the development of mucormycosis are nonspecific and include hyperglycemia, hematologic malignancies, neutropenia, pharmacologic immunosuppression, solid organ or bone marrow/stem cell t...
Amphibian ocular malformation associated with frog virus 3.
The Veterinary Journal 177(3):442 (2008)
During an on-going amphibian ecology study, a free-ranging American bullfrog (Rana catesbeiana) metamorph was captured in a pitfall trap adjacent to a constructed farm pond at the Plateau Research and Education Center (PREC) on the Cumberland Plateau near Crossville, Tennessee, USA. Grossly, the...
The vanishing nonforensic autopsy.
New England Journal of Medicine 358(9):873 (2008)
Preliminary evidence that American bullfrogs (Rana catesbeiana) are suitable hosts for Escherichia coli O157:H7.
Applied and Environmental Microbiology 73(12):4066 (2007)
We orally inoculated Rana catesbeiana tadpoles (n=23) and metamorphs (n=24) to test their suitability as hosts for Escherichia coli O157:H7. Tadpoles were housed in flowthrough aquaria and did not become infected. Metamorphs were housed in stagnant aquaria, and 54% tested positive through 14 day...
Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development.
Journal of Experimental Medicine 204(5):1037 (2007)
We previously reported (Bell, D., P. Chomarat, D. Broyles, G. Netto, G.M. Harb, S. Lebecque, J. Valladeau, J. Davoust, K.A. Palucka, and J. Banchereau. 1999. J. Exp. Med. 190: 1417-1426) that breast cancer tumors are infiltrated with mature dendritic cells (DCs), which cluster with CD4(+) T cell...
Attitudes toward the autopsy--an 8-state survey.
MedGenMed : Medscape general medicine 8(3):80 (2006)
National autopsy rates have declined for several decades, and the reasons for such decline remain contentious.
To elicit the opinions of one group of crucial decision makers as to the reasons for this decline and possible modes of reversal.
A 2-part survey, composed of multiple choice questions ...
Rabies encephalomyelitis: clinical, neuroradiological, and pathological findings in 4 transplant recipients.
Archives of Neurology 62(6):873 (2005)
Three patients received solid organ transplants from a common donor and were subsequently discharged from the hospital following an uneventful hospital course. Within 30 days, all 3 organ recipients returned to the hospital with varying symptoms that progressed to rapid neurological deterioratio...
Transmission of rabies virus from an organ donor to four transplant recipients.
New England Journal of Medicine 352(11):1103 (2005)
In 2004, four recipients of kidneys, a liver, and an arterial segment from a common organ donor died of encephalitis of an unknown cause.
We reviewed the medical records of the organ donor and the recipients. Blood, cerebrospinal fluid, and tissues from the recipients were tested with a variety ...