1. Enhanced resolution through thick tissue with structured illumination and adaptive optics.

    Journal of Biomedical Optics 20(2):26006 (2015) PMID 25714992

    Structured illumination microscopy provides twice the linear resolution of conventional fluorescence microscopy, but in thick samples, aberrations degrade the performance and limit the resolution. Here, we demonstrate structured illumination microscopy through 35 μm of tissue using adaptive opti...
  2. Enhanced resolution through thick tissue with structured illumination and adaptive optics.

    Journal of Biomedical Optics 20(2):26006 (2015) PMID 25714992

  3. Implications of an absolute simultaneity theory for cosmology and universe acceleration.

    PLoS ONE 9(12):e115550 (2014) PMID 25536116 PMCID PMC4275306

    An alternate Lorentz transformation, Absolute Lorentz Transformation (ALT), has similar kinematics to special relativity yet maintains absolute simultaneity in the context of a preferred reference frame. In this study, it is shown that ALT is compatible with current experiments to test Lorentz i...
  4. Implications of an absolute simultaneity theory for cosmology and universe acceleration.

    PLoS ONE 9(12):e115550 (2014) PMID 25536116 PMCID PMC4275306

    An alternate Lorentz transformation, Absolute Lorentz Transformation (ALT), has similar kinematics to special relativity yet maintains absolute simultaneity in the context of a preferred reference frame. In this study, it is shown that ALT is compatible with current experiments to test Lorentz i...
  5. Cancer driver candidate genes AVL9, DENND5A and NUPL1 contribute to MDCK cystogenesis.

    Oncoscience 1(12):854 (2014) PMID 25621300 PMCID PMC4303893

    AVL9, DENND5A and NUPL1 are among the cancer driver candidate genes previously identified via dog-human comparison, and may function in epithelial cell polarity as indicated by bioinformatics analysis. To better understand their cellular functions and roles in cancer, we knocked down each gene i...
  6. Cancer driver candidate genes AVL9, DENND5A and NUPL1 contribute to MDCK cystogenesis.

    Oncoscience 1(12):854 (2014) PMID 25621300

    AVL9, DENND5A and NUPL1 are among the cancer driver candidate genes previously identified via dog-human comparison, and may function in epithelial cell polarity as indicated by bioinformatics analysis. To better understand their cellular functions and roles in cancer, we knocked down each gene i...
  7. Implications of an absolute simultaneity theory for cosmology and universe acceleration.

    PLoS ONE 9(12):e115550 (2014) PMID 25536116 PMCID PMC4275306

    An alternate Lorentz transformation, Absolute Lorentz Transformation (ALT), has similar kinematics to special relativity yet maintains absolute simultaneity in the context of a preferred reference frame. In this study, it is shown that ALT is compatible with current experiments to test Lorentz i...
  8. Implications of an absolute simultaneity theory for cosmology and universe acceleration.

    PLoS ONE 9(12):e115550 (2014) PMID 25536116

    An alternate Lorentz transformation, Absolute Lorentz Transformation (ALT), has similar kinematics to special relativity yet maintains absolute simultaneity in the context of a preferred reference frame. In this study, it is shown that ALT is compatible with current experiments to test Lorentz i...
  9. Cancer driver candidate genes AVL9, DENND5A and NUPL1 contribute to MDCK cystogenesis.

    Oncoscience 1(12):854 (2014) PMID 25621300 PMCID PMC4303893

    AVL9, DENND5A and NUPL1 are among the cancer driver candidate genes previously identified via dog-human comparison, and may function in epithelial cell polarity as indicated by bioinformatics analysis. To better understand their cellular functions and roles in cancer, we knocked down each gene i...
  10. Cancer driver candidate genes AVL9, DENND5A and NUPL1 contribute to MDCK cystogenesis.

    Oncoscience 1(12):854 (2014) PMID 25621300 PMCID PMC4303893

    AVL9, DENND5A and NUPL1 are among the cancer driver candidate genes previously identified via dog-human comparison, and may function in epithelial cell polarity as indicated by bioinformatics analysis. To better understand their cellular functions and roles in cancer, we knocked down each gene i...
  11. C. elegansCell Cycle Analysis-Chapter 9

    Methods in Cell Biology 107:265 (2012) PMID 22226527

    Caenorhabditis elegans is an important system for the study of cell cycle regulation in the context of animal development. One of the most powerful features of C. elegans is the invariant cell lineage in which somatic cells initiate cell division at specific times within the d...
  12. Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors.

    Trends in Cell Biology 22(1):33 (2012) PMID 22154077 PMCID PMC3298816

    The mammalian CIP/KIP family of cyclin-dependent kinase (CDK) inhibitors (CKIs) comprises three proteins--p21(Cip1/WAF1), p27(Kip1), and p57(Kip2)--that bind and inhibit cyclin-CDK complexes, which are key regulators of the cell cycle. CIP/KIP CKIs have additional independent functions in regula...
  13. Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors.

    Trends in Cell Biology 22(1):33 (2012) PMID 22154077 PMCID PMC3298816

    The mammalian CIP/KIP family of cyclin-dependent kinase (CDK) inhibitors (CKIs) comprises three proteins--p21(Cip1/WAF1), p27(Kip1), and p57(Kip2)--that bind and inhibit cyclin-CDK complexes, which are key regulators of the cell cycle. CIP/KIP CKIs have additional independent functions in regula...
  14. Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors

    Trends in Cell Biology 22(1):33 (2012)

    The mammalian CIP/KIP family of cyclin-dependent kinase (CDK) inhibitors (CKIs) comprises three proteins – p21 Cip1/WAF1, p27 Kip1, and p57 Kip2 – that bind and inhibit cyclin–CDK complexes, which are key regulators of the cell cycle. CIP/KIP CKIs have additional independe...
  15. Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans.

    Genetics 188(3):549 (2011) PMID 21527776 PMCID PMC3176534

    Morphogenesis is an important component of animal development. Genetic redundancy has been proposed to be common among morphogenesis genes, posing a challenge to the genetic dissection of morphogenesis mechanisms. Genetic redundancy is more generally a challenge in biology, as large proportions ...
  16. Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans.

    Genetics 188(3):549 (2011) PMID 21527776 PMCID PMC3176534

    Morphogenesis is an important component of animal development. Genetic redundancy has been proposed to be common among morphogenesis genes, posing a challenge to the genetic dissection of morphogenesis mechanisms. Genetic redundancy is more generally a challenge in biology, as large proportions ...
  17. CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells.

    Developmental Cell 19(5):753 (2010) PMID 21074724 PMCID PMC3053091

    The Cip/Kip CDK inhibitor (CKI) p21(Cip1/WAF1) has a critical role in the nucleus to limit cell proliferation by inhibiting CDK-cyclin complexes. In contrast, cytoplasmic p21 regulates cell survival and the actin cytoskeleton. These divergent functions for p21 in different cellular compartments ...
  18. CRL2LRR-1 Targets a CDK Inhibitor for Cell Cycle Control in C. elegans and Actin-Based Motility Regulation in Human Cells

    Developmental Cell 19(5):753 (2010)

    The Cip/Kip CDK inhibitor (CKI) p21Cip1/WAF1 has a critical role in the nucleus to limit cell proliferation by inhibiting CDK-cyclin complexes. In contrast, cytoplasmic p21 regulates cell survival and the actin cytoskeleton. These divergent functions for p21 in different cellular compa...
  19. CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells.

    Developmental Cell 19(5):753 (2010) PMID 21074724 PMCID PMC3053091

    The Cip/Kip CDK inhibitor (CKI) p21(Cip1/WAF1) has a critical role in the nucleus to limit cell proliferation by inhibiting CDK-cyclin complexes. In contrast, cytoplasmic p21 regulates cell survival and the actin cytoskeleton. These divergent functions for p21 in different cellular compartments ...
  20. CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells.

    Developmental Cell 19(5):753 (2010) PMID 21074724 PMCID PMC3053091

    The Cip/Kip CDK inhibitor (CKI) p21(Cip1/WAF1) has a critical role in the nucleus to limit cell proliferation by inhibiting CDK-cyclin complexes. In contrast, cytoplasmic p21 regulates cell survival and the actin cytoskeleton. These divergent functions for p21 in different cellular compartments ...