1. Guanidinylated block copolymers for gene transfer: A comparison with amine-based materials for in vitro and in vivo gene transfer efficiency.

    Biomaterials 54:87 (2015) PMID 25907042 PMCID PMC4409668

    There is currently no cure for neuron loss in the brain, which can occur due to traumatic injury or neurodegenerative disease. One proposed method to enhance brain neurogenesis is gene transfer to neural progenitor cells. In this work, a guanidine-based copolymer was synthesized and compared to ...
  2. Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion.

    Biomaterials 35(31):8895 (2014) PMID 25064804 PMCID PMC4136545

    Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local injection o...
  3. Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion.

    Biomaterials 35(31):8895 (2014) PMID 25064804 PMCID PMC4136545

    Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local injection o...
  4. Guanidinylated block copolymers for gene transfer: A comparison with amine-based materials for in vitro and in vivo gene transfer efficiency

    Biomaterials (2014)

    There is currently no cure for neuron loss in the brain, which can occur due to traumatic injury or neurodegenerative disease. One method proposed to enhance neurogenesis in the brain is gene transfer to neural progenitor cells. In this work, a guanidine-based copolymer was synthesized...
  5. Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion

    Biomaterials (2014)

    Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local i...
  6. Dual responsive, stabilized nanoparticles for efficient in vivo plasmid delivery.

    Angewandte Chemie. International edition in Eng... 52(20):5377 (2013) PMID 23592572 PMCID PMC3738056

  7. Dual responsive, stabilized nanoparticles for efficient in vivo plasmid delivery.

    Angewandte Chemie. International edition in Eng... 52(20):5377 (2013) PMID 23592572 PMCID PMC3738056

  8. Remyelination reporter reveals prolonged refinement of spontaneously regenerated myelin.

    PNAS 110(10):4075 (2013) PMID 23431182 PMCID PMC3593891

    Neurological diseases and trauma often cause demyelination, resulting in the disruption of axonal function and integrity. Endogenous remyelination promotes recovery, but the process is not well understood because no method exists to definitively distinguish regenerated from preexisting myelin. T...
  9. Remyelination reporter reveals prolonged refinement of spontaneously regenerated myelin.

    PNAS 110(10):4075 (2013) PMID 23431182 PMCID PMC3593891

    Neurological diseases and trauma often cause demyelination, resulting in the disruption of axonal function and integrity. Endogenous remyelination promotes recovery, but the process is not well understood because no method exists to definitively distinguish regenerated from preexisting myelin. T...
  10. Melittin-grafted HPMA-oligolysine based copolymers for gene delivery.

    Biomaterials 34(9):2318 (2013) PMID 23261217 PMCID PMC3552146

    Non-viral gene delivery systems capable of transfecting cells in the brain are critical in realizing the potential impact of nucleic acid therapeutics for diseases of the central nervous system. In this study, the membrane-lytic peptide melittin was incorporated into block copolymers synthesized...
  11. Melittin-grafted HPMA-oligolysine based copolymers for gene delivery

    Biomaterials 34(9):2318 (2013)

    Non-viral gene delivery systems capable of transfecting cells in the brain are critical in realizing the potential impact of nucleic acid therapeutics for diseases of the central nervous system. In this study, the membrane-lytic peptide melittin was incorporated into block copolymers s...
  12. FMR1 transcript isoforms: association with polyribosomes; regional and developmental expression in mouse brain.

    PLoS ONE 8(3):e58296 (2013) PMID 23505481 PMCID PMC3591412

    The primary transcript of the mammalian Fragile X Mental Retardation-1 gene (Fmr1), like many transcripts in the central nervous system, is alternatively spliced to yield mRNAs encoding multiple proteins, which can possess quite different biochemical properties. Despite the fact that the relativ...
  13. FMR1 transcript isoforms: association with polyribosomes; regional and developmental expression in mouse brain.

    PLoS ONE 8(3):e58296 (2013) PMID 23505481 PMCID PMC3591412

    The primary transcript of the mammalian Fragile X Mental Retardation-1 gene (Fmr1), like many transcripts in the central nervous system, is alternatively spliced to yield mRNAs encoding multiple proteins, which can possess quite different biochemical properties. Despite the fact that the relativ...
  14. Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury.

    Journal of Neuroscience 29(20):6722 (2009) PMID 19458241 PMCID PMC2706133

    Progenitors that express NG2-proteoglycan are the predominant self-renewing cells within the CNS. NG2 progenitors replenish oligodendrocyte populations within the intact stem cell niche, and cycling NG2 cells are among the first cells to react to CNS insults. We investigated the role of NG2 prog...
  15. Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury.

    Journal of Neuroscience 29(20):6722 (2009) PMID 19458241 PMCID PMC2706133

    Progenitors that express NG2-proteoglycan are the predominant self-renewing cells within the CNS. NG2 progenitors replenish oligodendrocyte populations within the intact stem cell niche, and cycling NG2 cells are among the first cells to react to CNS insults. We investigated the role of NG2 prog...
  16. Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion

    Biomaterials (2008)

    Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local i...
  17. Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion

    Biomaterials (2008)

    Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local i...
  18. Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion

    Biomaterials (2008)

    Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local i...
  19. Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord.

    PNAS 104(45):17837 (2007) PMID 17978191 PMCID PMC2077035

    Adult neural progenitor cells (aNPCs) exhibit limited migration in vivo with the exception of the rostral migratory stream and injury-induced movement. Surprisingly little is known regarding those signals regulating attraction or inhibition of the aNPC. These studies demonstrate that aNPCs respo...
  20. Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord.

    PNAS 104(45):17837 (2007) PMID 17978191 PMCID PMC2077035

    Adult neural progenitor cells (aNPCs) exhibit limited migration in vivo with the exception of the rostral migratory stream and injury-induced movement. Surprisingly little is known regarding those signals regulating attraction or inhibition of the aNPC. These studies demonstrate that aNPCs respo...