1. Ryanodine Receptor Activation Induces Long-Term Plasticity of Spine Calcium Dynamics.

    PLoS Biology 13(6):e1002181 (2015) PMID 26098891 PMCID PMC4476683

    A key feature of signalling in dendritic spines is the synapse-specific transduction of short electrical signals into biochemical responses. Ca2+ is a major upstream effector in this transduction cascade, serving both as a depolarising electrical charge carrier at the membrane and an intracellul...
  2. State-dependencies of learning across brain scales.

    Frontiers in Computational Neuroscience 9:1 (2015) PMID 25767445 PMCID PMC4341560

    Learning is a complex brain function operating on different time scales, from milliseconds to years, which induces enduring changes in brain dynamics. The brain also undergoes continuous "spontaneous" shifts in states, which, amongst others, are characterized by rhythmic activity of various freq...
  3. KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.

    Nature Communications 6:6254 (2015) PMID 25649132

    KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) K(+) channels dampen neuronal excitability and their functional impairment may lead to epilepsy. Less is known about KCNQ5 (Kv7.5), which also displays wide expression in the brain. Here we show an unexpected role of KCNQ5 in dampening synaptic inhibition and shap...
  4. KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.

    Nature Communications 6:6254 (2015) PMID 25649132

    KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) K(+) channels dampen neuronal excitability and their functional impairment may lead to epilepsy. Less is known about KCNQ5 (Kv7.5), which also displays wide expression in the brain. Here we show an unexpected role of KCNQ5 in dampening synaptic inhibition and shap...
  5. Retrograde Signaling Causes Excitement

    Neuron 81(4):717 (2014) PMID 24559666

    Retrograde signaling is a powerful tool to shape synaptic transmission, typically inducing inhibition of transmitter release. A new study published in this issue of Neuron by Carta et al. (2014) now provides strong support for arachidonic acid as a potentiating retrograde messenger. ...
  6. Retrograde signaling causes excitement.

    Neuron 81(4):717 (2014) PMID 24559666

    Retrograde signaling is a powerful tool to shape synaptic transmission, typically inducing inhibition of transmitter release. A new study published in this issue of Neuron by Carta et al. (2014) now provides strong support for arachidonic acid as a potentiating retrograde messenger. Copyright © ...
  7. Retrograde Signaling Causes Excitement

    Neuron 81(4):717 (2014)

    Retrograde signaling is a powerful tool to shape synaptic transmission, typically inducing inhibition of transmitter release. A new study published in this issue of Neuron by Carta et al. (2014) now provides strong support for arachidonic acid as a potentiating retrograde messenger. ...
  8. Inhibitory Gradient along the Dorsoventral Axis in the Medial Entorhinal Cortex

    Neuron 79(6):1197 (2013)

    Local inhibitory microcircuits in the medial entorhinal cortex (MEC) and their role in network activity are little investigated. Using a combination of electrophysiological, optical, and morphological circuit analysis tools, we find that layer II stellate cells are embedded in a dense ...
  9. Inhibitory gradient along the dorsoventral axis in the medial entorhinal cortex.

    Neuron 79(6):1197 (2013) PMID 24050405

    Local inhibitory microcircuits in the medial entorhinal cortex (MEC) and their role in network activity are little investigated. Using a combination of electrophysiological, optical, and morphological circuit analysis tools, we find that layer II stellate cells are embedded in a dense local inhi...
  10. Inhibitory gradient along the dorsoventral axis in the medial entorhinal cortex.

    Neuron 79(6):1197 (2013) PMID 24050405

    Local inhibitory microcircuits in the medial entorhinal cortex (MEC) and their role in network activity are little investigated. Using a combination of electrophysiological, optical, and morphological circuit analysis tools, we find that layer II stellate cells are embedded in a dense local inhi...
  11. Clinical efficacy and safety of an implantable cardioverter-defibrillator lead with a floating atrial sensing dipole.

    Pacing and Clinical Electrophysiology 36(8):952 (2013) PMID 23692262

    The concept of a single-lead implantable cardioverter-defibrillator (ICD), with a floating dipole, has been proven safe and functional. The studied active-fixation, steroid-eluting lead (Linox(smart) S DX, BIOTRONIK SE & Co KG, Berlin, Germany) is one French thinner than its predecessor and coat...
  12. Clinical efficacy and safety of an implantable cardioverter-defibrillator lead with a floating atrial sensing dipole.

    Pacing and Clinical Electrophysiology 36(8):952 (2013) PMID 23692262

    The concept of a single-lead implantable cardioverter-defibrillator (ICD), with a floating dipole, has been proven safe and functional. The studied active-fixation, steroid-eluting lead (Linox(smart) S DX, BIOTRONIK SE & Co KG, Berlin, Germany) is one French thinner than its predecessor and coat...
  13. Recruitment of oriens-lacunosum-moleculare interneurons during hippocampal ripples.

    PNAS 110(11):4398 (2013) PMID 23440221 PMCID PMC3600450

    Sharp wave-associated ∼200-Hz ripple oscillations in the hippocampus have been implicated in the consolidation of memories. However, knowledge on mechanisms underlying ripples is still scarce, in particular with respect to synaptic involvement of specific cell types. Here, we used cell-attached ...
  14. Recruitment of oriens-lacunosum-moleculare interneurons during hippocampal ripples.

    PNAS 110(11):4398 (2013) PMID 23440221 PMCID PMC3600450

    Sharp wave-associated ∼200-Hz ripple oscillations in the hippocampus have been implicated in the consolidation of memories. However, knowledge on mechanisms underlying ripples is still scarce, in particular with respect to synaptic involvement of specific cell types. Here, we used cell-attached ...
  15. Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2.

    PNAS 110(6):E526 (2013) PMID 23345427 PMCID PMC3568307

    Neurotransmission depends on the exocytic fusion of synaptic vesicles (SVs) and their subsequent reformation either by clathrin-mediated endocytosis or budding from bulk endosomes. How synapses are able to rapidly recycle SVs to maintain SV pool size, yet preserve their compositional identity, i...
  16. Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2.

    PNAS 110(6):E526 (2013) PMID 23345427 PMCID PMC3568307

    Neurotransmission depends on the exocytic fusion of synaptic vesicles (SVs) and their subsequent reformation either by clathrin-mediated endocytosis or budding from bulk endosomes. How synapses are able to rapidly recycle SVs to maintain SV pool size, yet preserve their compositional identity, i...
  17. A LED-based method for monitoring NAD(P)H and FAD fluorescence in cell cultures and brain slices.

    Journal of Neuroscience Methods 212(2):222 (2013) PMID 23142181

    Nicotinamide- and flavine-adenine-dinucleotides (NAD(P)H and FADH₂) are electron carriers involved in cellular energy metabolism and in a multitude of enzymatic processes. As reduced NAD(P)H and oxidised FAD molecules are fluorescent, changes in tissue auto-fluorescence provide valuable informat...
  18. A LED-based method for monitoring NAD(P)H and FAD fluorescence in cell cultures and brain slices

    Journal of Neuroscience Methods 212(2):222 (2013)

    Highlights ► HBO lamp of a fluorescence microscope was replaced by a combination of two LEDs. ► NAD(P)H fluorescence bleaching in cell cultures was less with LED excitation. ► LED allowed for fast-bleaching and recovery of NAD(P)H fluorescence. ► Signal to noise ratio of a ph...
  19. Role of RIM1α in short- and long-term synaptic plasticity at cerebellar parallel fibres.

    Nature Communications 4:2392 (2013) PMID 23999086

    The presynaptic terminals of synaptic connections are composed of a complex network of interacting proteins that collectively ensure proper synaptic transmission and plasticity characteristics. The key components of this network are the members of the RIM protein family. Here we show that RIM1α ...
  20. Role of RIM1α in short- and long-term synaptic plasticity at cerebellar parallel fibres.

    Nature Communications 4:2392 (2013) PMID 23999086

    The presynaptic terminals of synaptic connections are composed of a complex network of interacting proteins that collectively ensure proper synaptic transmission and plasticity characteristics. The key components of this network are the members of the RIM protein family. Here we show that RIM1α ...