1. New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal pH metry in extraesophageal gastroesophageal reflux disease.

    World Journal of Gastroenterology 21(3):982 (2015) PMID 25624734 PMCID PMC4299353

    To determine the laryngeal H+K+-ATPase and pharyngeal pH in patients with laryngopharyngeal reflux (LPR)-symptoms as well as to assess the symptom scores during PPI therapy. Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area (immunohistochemistry...
  2. New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal pH metry in extraesophageal gastroesophageal reflux disease.

    World Journal of Gastroenterology 21(3):982 (2015) PMID 25624734

    To determine the laryngeal H+K+-ATPase and pharyngeal pH in patients with laryngopharyngeal reflux (LPR)-symptoms as well as to assess the symptom scores during PPI therapy. Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area (immunohistochemistry...
    PDF not found
  3. New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal pH metry in extraesophageal gastroesophageal reflux disease.

    World Journal of Gastroenterology 21(3):982 (2015) PMID 25624734

    To determine the laryngeal H+K+-ATPase and pharyngeal pH in patients with laryngopharyngeal reflux (LPR)-symptoms as well as to assess the symptom scores during PPI therapy. Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area (immunohistochemistry...
    PDF not found
  4. Dominant role of interstitial cells of Cajal in nitrergic relaxation of murine lower oesophageal sphincter.

    Journal of Physiology 593(2):403 (2015) PMID 25630261 PMCID PMC4303385

    Nitric oxide (NO) is an important inhibitory neurotransmitter in the gastrointestinal tract. Oesophageal achalasia may result from impairment of nitrergic relaxation. Smooth muscle cells (SMCs) have been accepted to be the major targets for neuronal NO to mediate relaxation. However, besides SMC...
  5. Dominant role of interstitial cells of Cajal in nitrergic relaxation of murine lower oesophageal sphincter.

    Journal of Physiology 593(2):403 (2015) PMID 25630261 PMCID PMC4303385

    Oesophageal achalasia is a disease known to result from reduced relaxation of the lower oesophageal sphincter (LES). Nitric oxide (NO) is one of the main inhibitory transmitters. NO-sensitive guanylyl cyclase (NO-GC) acts as the key target of NO and, by the generation of cGMP, mediates nitrergic...
  6. Dominant role of interstitial cells of Cajal in nitrergic relaxation of murine lower oesophageal sphincter.

    Journal of Physiology 593(2):403 (2015) PMID 25630261 PMCID PMC4303385

    Oesophageal achalasia is a disease known to result from reduced relaxation of the lower oesophageal sphincter (LES). Nitric oxide (NO) is one of the main inhibitory transmitters. NO-sensitive guanylyl cyclase (NO-GC) acts as the key target of NO and, by the generation of cGMP, mediates nitrergic...
  7. Adult c-Kit(+) progenitor cells are necessary for maintenance and regeneration of olfactory neurons.

    Journal of Comparative Neurology 523(1):15 (2015) PMID 25044230 PMCID PMC4232589

    The olfactory epithelium houses chemosensory neurons, which transmit odor information from the nose to the brain. In adult mammals, the olfactory epithelium is a uniquely robust neuroproliferative zone, with the ability to replenish its neuronal and non-neuronal populations due to the presence o...
  8. Adult c-Kit(+) progenitor cells are necessary for maintenance and regeneration of olfactory neurons.

    Journal of Comparative Neurology 523(1):15 (2015) PMID 25044230 PMCID PMC4232589

    The olfactory epithelium houses chemosensory neurons, which transmit odor information from the nose to the brain. In adult mammals, the olfactory epithelium is a uniquely robust neuroproliferative zone, with the ability to replenish its neuronal and non-neuronal populations due to the presence o...
  9. A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.

    Nature Genetics 47(1):47 (2015) PMID 25485836

    Here we describe a conditional piggyBac transposition system in mice and report the discovery of large sets of new cancer genes through a pancreatic insertional mutagenesis screen. We identify Foxp1 as an oncogenic transcription factor that drives pancreatic cancer invasion and spread in a mouse...
  10. Adult c-Kit(+) progenitor cells are necessary for maintenance and regeneration of olfactory neurons.

    Journal of Comparative Neurology 523(1):15 (2015) PMID 25044230 PMCID PMC4232589

    The olfactory epithelium houses chemosensory neurons, which transmit odor information from the nose to the brain. In adult mammals, the olfactory epithelium is a uniquely robust neuroproliferative zone, with the ability to replenish its neuronal and non-neuronal populations due to the presence o...
  11. A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.

    Nature Genetics 47(1):47 (2015) PMID 25485836

    Here we describe a conditional piggyBac transposition system in mice and report the discovery of large sets of new cancer genes through a pancreatic insertional mutagenesis screen. We identify Foxp1 as an oncogenic transcription factor that drives pancreatic cancer invasion and spread in a mouse...
  12. In-vitro bipolar nano- and microsecond electro-pulse bursts for irreversible electroporation therapies.

    Bioelectrochemistry 100:69 (2014) PMID 25131187

    Under the influence of external electric fields, cells experience a rapid potential buildup across the cell membrane. Above a critical threshold of electric field strength, permanent cell damage can occur, resulting in cell death. Typical investigations of electroporation effects focus on two di...
  13. In-vitro bipolar nano- and microsecond electro-pulse bursts for irreversible electroporation therapies.

    Bioelectrochemistry 100:69 (2014) PMID 25131187

    Under the influence of external electric fields, cells experience a rapid potential buildup across the cell membrane. Above a critical threshold of electric field strength, permanent cell damage can occur, resulting in cell death. Typical investigations of electroporation effects focus on two di...
  14. In-vitro bipolar nano- and microsecond electro-pulse bursts for irreversible electroporation therapies

    Bioelectrochemistry 100:69 (2014)

    Under the influence of external electric fields, cells experience a rapid potential buildup across the cell membrane. Above a critical threshold of electric field strength, permanent cell damage can occur, resulting in cell death. Typical investigations of electroporation effects focus...
  15. Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α.

    Genes & Development 28(23):2621 (2014) PMID 25452273 PMCID PMC4248293

    Increased PI 3-kinase (PI3K) signaling in pancreatic ductal adenocarcinoma (PDAC) correlates with poor prognosis, but the role of class I PI3K isoforms during its induction remains unclear. Using genetically engineered mice and pharmacological isoform-selective inhibitors, we found that the p110...
  16. Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α.

    Genes & Development 28(23):2621 (2014) PMID 25452273 PMCID PMC4248293

    Increased PI 3-kinase (PI3K) signaling in pancreatic ductal adenocarcinoma (PDAC) correlates with poor prognosis, but the role of class I PI3K isoforms during its induction remains unclear. Using genetically engineered mice and pharmacological isoform-selective inhibitors, we found that the p110...
  17. Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α.

    Genes & Development 28(23):2621 (2014) PMID 25452273 PMCID PMC4248293

    Increased PI 3-kinase (PI3K) signaling in pancreatic ductal adenocarcinoma (PDAC) correlates with poor prognosis, but the role of class I PI3K isoforms during its induction remains unclear. Using genetically engineered mice and pharmacological isoform-selective inhibitors, we found that the p110...
  18. A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.

    Nature Medicine 20(11):1340 (2014) PMID 25326799 PMCID PMC4270133

    Genetically engineered mouse models (GEMMs) have dramatically improved our understanding of tumor evolution and therapeutic resistance. However, sequential genetic manipulation of gene expression and targeting of the host is almost impossible using conventional Cre-loxP-based models. We have dev...
  19. A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.

    Nature Medicine 20(11):1340 (2014) PMID 25326799 PMCID PMC4270133

    Genetically engineered mouse models (GEMMs) have dramatically improved our understanding of tumor evolution and therapeutic resistance. However, sequential genetic manipulation of gene expression and targeting of the host is almost impossible using conventional Cre-loxP-based models. We have dev...
  20. A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.

    Nature Medicine 20(11):1340 (2014) PMID 25326799 PMCID PMC4270133

    Genetically engineered mouse models (GEMMs) have dramatically improved our understanding of tumor evolution and therapeutic resistance. However, sequential genetic manipulation of gene expression and targeting of the host is almost impossible using conventional Cre-loxP-based models. We have dev...