Hypromellose succinate-crosslinked chitosan hydrogel films for potential wound dressing.
International Journal of Biological Macromolecules 91:85 (2016)
The objective of this study was to develop novel hydrogel films based on carboxyl-modified hypromellose-crosslinked chitosan for potential wound dressing. Hypromellose (HPMC) was grafted with succinic acid to yield hypromellose succinate (HPMCS), and then the reinforced hydrogel films of HPMCS-c...
The Synthesis of Multisubstituted Pyrroles via a Copper-Catalyzed Tandem Three-Component Reaction.
Organic Letters 18(16):4032 (2016)
An unprecedented nucleophilic addition/cyclization/aromatization cascade of basic chemicals, i.e., aromatic alkenes/alkynes, trimethylsilyl cyanide and N,N-disubstituted formamide, has been developed to give a series of multisubstituted pyrroles in moderate to good yields with high regioselectiv...
Prevalence and phylogenetic characterization of canine coronavirus from diseased pet dogs in Beijing, China.
SCIENCE CHINA Life Science 59(8):860 (2016)
Identification of two recurrent mutations of COL1A1 gene in Chinese Van der Hoeve syndrome patients.
Acta Oto-Laryngologica 136(8):786 (2016)
The two discovered mutations in COL1A1 gene, although first reported in China, are recurrent ones that have also been found elsewhere in type I osteogenesis imperfecta patients, suggesting their role in pathogenesis of Van der Hoeve syndrome.
The aim of this study is to find mutational patterns ...
Eugenics and Mandatory Informed Prenatal Genetic Testing: A Unique Perspective from China.
Developing World Bioethics 16(2):107 (2016)
The application of genetic technologies in China, especially in the area of prenatal genetic testing, is rapidly increasing in China. In the wealthy regions of China, prenatal genetic testing is already very widely adopted. We argue that the government should actively promote prenatal genetic te...
Room-Temperature Solution-Processed NiOx:PbI2 Nanocomposite Structures for Realizing High-Performance Perovskite Photodetectors.
ACS Nano 10(7):6808 (2016)
While methylammonium lead iodide (MAPbI3) with interesting properties, such as a direct band gap, high and well-balanced electron/hole mobilities, as well as long electron/hole diffusion length, is a potential candidate to become the light absorbers in photodetectors, the challenges for realizin...
Light-Driven Overall Water Splitting Enabled by a Photo-Dember Effect Realized on 3D Plasmonic Structures.
ACS Nano 10(7):6693 (2016)
Photoelectric conversion driven by sunlight has a broad range of energy/environmental applications (e.g., in solar cells and water splitting). However, difficulties are encountered in the separation of photoexcited charges. Here, we realize a long-range (∼1.5 μm period) electric polarization via...
Challenges and Perspectives in Designing Artificial Photosynthetic Systems.
Chemistry: A European Journal 22(29):9870 (2016)
The development of artificial photosynthetic systems for water splitting and CO2 reduction on a large scale for practical applications is the ultimate goal towards worldwide sustainability. This Concept highlights the state-of-the-art research trends of artificial photosynthesis concepts and des...
Knockdown of Astrocyte Elevated Gene-1 Inhibits Activation of Hepatic Stellate Cells.
Digestive Diseases and Sciences 61(7):1961 (2016)
Astrocyte elevated gene-1 (AEG-1) is a positive regulator of tumorigenesis and a valuable prognostic marker of a diverse array of cancers, including liver cancer; however, the relationship between AEG-1 and hepatic fibrogenesis is not known.
The objective of this study was to explore the express...
Adsorption mechanism of different organic chemicals on fluorinated carbon nanotubes.
Chemosphere 154:258 (2016)
Multi-walled carbon nanotubes (MC) were fluorinated by a solid-phase reaction method using polytetrafluoroethylene (PTFE). The surface alteration of carbon nanotubes after fluorination (MC-F) was confirmed based on surface elemental analysis, TEM and SEM. The incorporation of F on MC surface was...
Procyanidins, from Castanea mollissima Bl. shell, induces autophagy following apoptosis associated with PI3K/AKT/mTOR inhibition in HepG2 cells.
Biomedicine & Pharmacotherapy 81:15 (2016)
Procyanidins from Castanea mollissima Bl. shell (CSPCs) induced autophagy and apoptosis in HepG2 cells and its mechanism remains to be examined. In this paper, autophagy was measured by the lipid modification of light chain-3 (LC3) and the formation of autophagosomes. Hoechst 33258 staining and ...
Adiponectin Exerts Neurotrophic Effects on Dendritic Arborization, Spinogenesis, and Neurogenesis of the Dentate Gyrus of Male Mice.
Endocrinology 157(7):2853 (2016)
The hippocampus, a brain region critical for learning, memory and emotional processing, maintains its capacity to undergo structural plasticity throughout life. Hippocampal structural plasticity can be modulated by a number of intrinsic and extrinsic factors. This study investigated the effects ...
A Turn on ESIPT Probe for Rapid and Ratiometric Fluorogenic Detection of Hg(2+) and its Application in Live-Cell Imaging.
Journal of Fluorescence 26(4):1367 (2016)
A probe based on 2-(2'-hydroxyphenyl) benzothiazole (HBT) and thiophosphate has been synthesized and used for the ratiometric detection of Hg(2+). The probe was designed in such a way that the excited state intramolecular proton transfer (ESIPT) of the HBT moiety get blocked. The probe exhibited...
Facile Self-Cross-Linking Synthesis of 3D Nanoporous Co3O4/Carbon Hybrid Electrode Materials for Supercapacitors.
ACS Applied Materials & Interfaces 8(25):16035 (2016)
A hybrid electrode material with ultrafine Co3O4 nanoparticles embedded throughout a hierarchically nanoporous graphitic carbon matrix has been obtained via a facile self-cross-linking route. Sodium alginate, a biopolymer with an ability of cross-linking with multivalent cobalt cations to form o...
Bioinspired Multifunctional Paper-Based rGO Composites for Solar-Driven Clean Water Generation.
ACS Applied Materials & Interfaces 8(23):14628 (2016)
Reusing polluted water through various decontamination techniques has appeared as one of the most practical approaches to address the global shortage of clean water. Rather than relying on single decontamination mechanism, herein we report the preparation and utilization of paper-based composite...
MicroRNA-155 promotes tumor growth of human hepatocellular carcinoma by targeting ARID2.
International Journal of Oncology 48(6):2425 (2016)
Aberrant expression of microRNA-155 (miR-155) has been reported in several human cancers and is associated with prognosis of patients. However, the clinical significance of miR‑155 and its underlying mechanisms involved in hepatocarcinogenesis remain to be determined. In this study, we demonstra...
Inhibition of AKT sensitizes chemoresistant ovarian cancer cells to cisplatin by abrogating S and G2/M arrest.
Experimental and Molecular Pathology 100(3):506 (2016)
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is frequently altered in human malignancies and Akt over-expression and/or activation induces malignant transformation and chemoresistance. However, the role of Akt in the mechanisms of chemoresistance remains elusive. Here we reported that ci...
Effects of norspermidine on Pseudomonas aeruginosa biofilm formation and eradication.
MicrobiologyOpen 5(3):402 (2016)
Biofilms are defined as aggregation of single cell microorganisms and associated with over 80% of all the microbial infections. Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen capable of leading to various infections in immunocompromised people. Recent studies showed that norspe...
Finite-difference time-domain-based optical microscopy simulation of dispersive media facilitates the development of optical imaging techniques.
Journal of Biomedical Optics 21(6):65004 (2016)
[Efficacy Observation for Treating Ankylosing Spondylitis by Chinese Herbs and Recombinant Hu- man Tumor Necrosis Factor Receptor II-Antibody Fusion Protein].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zho... 36(6):663 (2016)
To observe the clinical effect of Chinese medical (CM) syndrome differentiation based Chinese herbs and recombinant human tumor necrosis factor receptor II-antibody fusion protein (etanercept) for treating ankylosing spondylitis (AS) patients.
Totally 35 AS patients were treated with syndrome di...