1. A doxycycline-loaded polymer-lipid encapsulation matrix coating for the prevention of implant-related osteomyelitis due to doxycycline-resistant methicillin-resistant Staphylococcus aureus.

    Journal of Controlled Release 209:47 (2015) PMID 25910578

    Implant-associated bone infections caused by antibiotic-resistant pathogens pose significant clinical challenges to treating physicians. Prophylactic strategies that act against resistant organisms, such as methicillin-resistant Staphylococcus aureus (MRSA), are urgently required. In the present...
  2. Simplified silvestrol analogues with potent cytotoxic activity.

    Chemmedchem 9(7):1556 (2014) PMID 24677741

    The complex natural products silvestrol (1) and episilvestrol (2) are inhibitors of translation initiation through binding to the DEAD-box helicase eukaryotic initiation factor 4A (eIF4A). Both compounds are potently cytotoxic to cancer cells in vitro, and 1 has demonstrated efficacy in vivo in ...
  3. Ethical and clinical dilemmas in patients with head and neck tumors visiting a field hospital in the Philippines.

    American journal of disaster medicine 9(3):211 (2014) PMID 25348386

    To describe clinical and ethical dilemmas in patients presenting with head and neck (H&N) tumors to a field hospital in the "subacute" period following a typhoon. We retrospectively reviewed charts of H&N patients presenting to an integrated Israeli-Filipino medical facility, which was operated ...
  4. Simplified silvestrol analogues with potent cytotoxic activity.

    Chemmedchem 9(7):1556 (2014) PMID 24677741

    The complex natural products silvestrol (1) and episilvestrol (2) are inhibitors of translation initiation through binding to the DEAD-box helicase eukaryotic initiation factor 4A (eIF4A). Both compounds are potently cytotoxic to cancer cells in vitro, and 1 has demonstrated efficacy in vivo in ...
  5. Ethical and clinical dilemmas in patients with head and neck tumors visiting a field hospital in the Philippines.

    American journal of disaster medicine 9(3):211 (2014) PMID 25348386

    To describe clinical and ethical dilemmas in patients presenting with head and neck (H&N) tumors to a field hospital in the "subacute" period following a typhoon. We retrospectively reviewed charts of H&N patients presenting to an integrated Israeli-Filipino medical facility, which was operated ...
  6. Further insights into the effects of pre-organizing the BimBH3 helix.

    ACS Chemical Biology 9(3):838 (2014) PMID 24547872

  7. Further insights into the effects of pre-organizing the BimBH3 helix.

    ACS Chemical Biology 9(3):838 (2014) PMID 24547872

  8. Further insights into the effects of pre-organizing the BimBH3 helix.

    ACS Chemical Biology 9(3):838 (2014) PMID 24547872

  9. Online medicine for pregnant women.

    International Journal of Telemedicine and Appli... 2014:379427 (2014) PMID 25132848 PMCID PMC4122028

    Objective. To assess the use of cell phones and email as means of communication between pregnant women and their gynecologists and family physicians. Study Design. A cross-sectional study of pregnant women at routine followup. One hundred and twenty women participated in the study. Results. The ...
  10. Online medicine for pregnant women.

    International Journal of Telemedicine and Appli... 2014:379427 (2014) PMID 25132848 PMCID PMC4122028

    Objective. To assess the use of cell phones and email as means of communication between pregnant women and their gynecologists and family physicians. Study Design. A cross-sectional study of pregnant women at routine followup. One hundred and twenty women participated in the study. Results. The ...
  11. The vagina dialogues: genital self-image and communication with physicians about sexual dysfunction and dissatisfaction among Jewish patients in a women's health clinic in southern Israel.

    Journal of Sexual Medicine 10(12):3059 (2013) PMID 24112414

    The health-care system offers a variety of solutions for problems related to sexual dysfunction. To gain access to treatment options, women must be willing to discuss these issues with their physicians. To examine the extent to which women discuss issues of sexual dysfunction with their physicia...
  12. The vagina dialogues: genital self-image and communication with physicians about sexual dysfunction and dissatisfaction among Jewish patients in a women's health clinic in southern Israel.

    Journal of Sexual Medicine 10(12):3059 (2013) PMID 24112414

    The health-care system offers a variety of solutions for problems related to sexual dysfunction. To gain access to treatment options, women must be willing to discuss these issues with their physicians. To examine the extent to which women discuss issues of sexual dysfunction with their physicia...
  13. Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.

    Journal of Neuroscience 33(1):315 (2013) PMID 23283344 PMCID PMC3640269

    Specific somatosensations may be processed by different subsets of primary afferents. C-fibers expressing heat-sensitive TRPV1 channels are proposed, for example, to be heat but not mechanical pain detectors. To phenotype in rats the sensory function of TRPV1(+) afferents, we rapidly and selecti...
  14. Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.

    Journal of Neuroscience 33(1):315 (2013) PMID 23283344 PMCID PMC3640269

    Specific somatosensations may be processed by different subsets of primary afferents. C-fibers expressing heat-sensitive TRPV1 channels are proposed, for example, to be heat but not mechanical pain detectors. To phenotype in rats the sensory function of TRPV1(+) afferents, we rapidly and selecti...
  15. The Use of JAK-specific inhibitors as chemical biology tools.

    Methods in Molecular Biology 967:99 (2013) PMID 23296724

    The JAK family of protein tyrosine kinases are now recognized as important participants in a wide range of pathologies, from cancer to inflammatory diseases. In the last decade, the drive to develop drugs targeting members of this family has begun to deliver a panel of small molecule inhibitors ...
  16. The Use of JAK-specific inhibitors as chemical biology tools.

    Methods in Molecular Biology 967:99 (2013) PMID 23296724

    The JAK family of protein tyrosine kinases are now recognized as important participants in a wide range of pathologies, from cancer to inflammatory diseases. In the last decade, the drive to develop drugs targeting members of this family has begun to deliver a panel of small molecule inhibitors ...
  17. Synthesis and biological evaluation of a potent salicylihalamide A lactam analogue.

    Organic & Biomolecular Chemistry 10(40):8147 (2012) PMID 22964776

    The first synthesis of a lactam analogue of salicylihalamide A (1) is reported. A key step in the approach was a photochemical acylation coupling between amine 10 and dioxinone 9 to form the amide 19. Acetylation followed by RCM with Grubbs 1st generation catalyst gave the desired E-lactam 23 (E...
  18. Synthesis and biological evaluation of a potent salicylihalamide A lactam analogue.

    Organic & Biomolecular Chemistry 10(40):8147 (2012) PMID 22964776

    The first synthesis of a lactam analogue of salicylihalamide A (1) is reported. A key step in the approach was a photochemical acylation coupling between amine 10 and dioxinone 9 to form the amide 19. Acetylation followed by RCM with Grubbs 1st generation catalyst gave the desired E-lactam 23 (E...
  19. E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis.

    Blood 120(4):822 (2012) PMID 22689861 PMCID PMC3709628

    Neoplastic transformation requires the elimination of key tumor suppressors, which may result from E3 ligase-mediated proteasomal degradation. We previously demonstrated a key role for the E3 ubiquitin ligase E6AP in the regulation of promyelocytic leukemia protein (PML) stability and formation ...
  20. E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis.

    Blood 120(4):822 (2012) PMID 22689861 PMCID PMC3709628

    Neoplastic transformation requires the elimination of key tumor suppressors, which may result from E3 ligase-mediated proteasomal degradation. We previously demonstrated a key role for the E3 ubiquitin ligase E6AP in the regulation of promyelocytic leukemia protein (PML) stability and formation ...