1. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364 PMCID PMC4344913

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  2. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364 PMCID PMC4344913

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  3. A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate

    Cell 160(5):1013 (2015)

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases ...
  4. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  5. Visual acuity is reduced in alpha 7 nicotinic receptor knockout mice.

    Investigative Ophthalmology & Visual Science 53(3):1211 (2012) PMID 22281823

    Nicotinic receptors (nAChRs) are part of a heterogeneous family of pentameric ligand-gated ion channels that are widely expressed in the visual system. The impact of α7 homomeric nAChRs on visual function was investigated using mutant mice lacking the α7 nicotinic receptor subunit. The spatial r...
  6. Visual acuity is reduced in alpha 7 nicotinic receptor knockout mice.

    Investigative Ophthalmology & Visual Science 53(3):1211 (2012) PMID 22281823

    Nicotinic receptors (nAChRs) are part of a heterogeneous family of pentameric ligand-gated ion channels that are widely expressed in the visual system. The impact of α7 homomeric nAChRs on visual function was investigated using mutant mice lacking the α7 nicotinic receptor subunit. The spatial r...
  7. Transposon-Mediated Transgenesis in the Short-Lived African Killifish Nothobranchius furzeri, a Vertebrate Model for Aging.

    G3: Genes, Genomes, Genetics 1(7):531 (2011) PMID 22384364 PMCID PMC3276177

    The African killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in captivity. N. furzeri comprises several wild-derived strains with striking differences in longevity ranging from 3 to 9 months, which makes it a powerful vertebrate model for aging research. The sho...
  8. Transposon-Mediated Transgenesis in the Short-Lived African Killifish Nothobranchius furzeri, a Vertebrate Model for Aging.

    G3: Genes, Genomes, Genetics 1(7):531 (2011) PMID 22384364 PMCID PMC3276177

    The African killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in captivity. N. furzeri comprises several wild-derived strains with striking differences in longevity ranging from 3 to 9 months, which makes it a powerful vertebrate model for aging research. The sho...
  9. Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri.

    Genetics 183(4):1385 (2009) PMID 19786620 PMCID PMC2787427

    The African fish Nothobranchius furzeri is the shortest-lived vertebrate species that can reproduce in captivity, with a median life span of 9-11 weeks for the shortest-lived strain. Natural populations of N. furzeri display differences in life span, aging biomarkers, behavior, and color, which ...
  10. Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri.

    Genetics 183(4):1385 (2009) PMID 19786620 PMCID PMC2787427

    The African fish Nothobranchius furzeri is the shortest-lived vertebrate species that can reproduce in captivity, with a median life span of 9-11 weeks for the shortest-lived strain. Natural populations of N. furzeri display differences in life span, aging biomarkers, behavior, and color, which ...
  11. Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.

    PLoS ONE 3(12):e3866 (2008) PMID 19052641 PMCID PMC2585814

    A laboratory inbred strain of the annual fish Nothobranchius furzeri shows exceptionally short life expectancy and accelerated expression of age markers. In this study, we analyze new wild-derived lines of this short-lived species. We characterized captive survival and age-related traits in F1 a...
  12. Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.

    PLoS ONE 3(12):e3866 (2008) PMID 19052641 PMCID PMC2585814

    A laboratory inbred strain of the annual fish Nothobranchius furzeri shows exceptionally short life expectancy and accelerated expression of age markers. In this study, we analyze new wild-derived lines of this short-lived species. We characterized captive survival and age-related traits in F1 a...
  13. The short-lived fishNothobranchius furzerias a new model system for aging studies

    Experimental Gerontology 42(1):81 (2007)

    Genetic and pharmacological research on aging is hampered by the lifespan of available vertebrate models. We recently initiated studies on Nothobranchius furzeri, a species with a maximum life expectancy in captivity of just three months which represents the shortest documented capti...
  14. The short-lived fish Nothobranchius furzeri as a new model system for aging studies.

    Experimental Gerontology 42(1-2):81 (2007) PMID 17049789

    Genetic and pharmacological research on aging is hampered by the lifespan of available vertebrate models. We recently initiated studies on Nothobranchius furzeri, a species with a maximum life expectancy in captivity of just three months which represents the shortest documented captive lifespan ...
  15. The short-lived fishNothobranchius furzerias a new model system for aging studies

    Experimental Gerontology 42(1):81 (2007)

    Genetic and pharmacological research on aging is hampered by the lifespan of available vertebrate models. We recently initiated studies on Nothobranchius furzeri, a species with a maximum life expectancy in captivity of just three months which represents the shortest documented capti...
  16. Resveratrol and the pharmacology of aging: a new vertebrate model to validate an old molecule.

    Cell Cycle 5(10):1027 (2006) PMID 16687936

    The natural phytoalexin resveratrol, found in grapes and red wine, recently rose to public fame for its positive effects on longevity in yeasts, worms and flies. Resveratrol anti-cancer and anti-inflammatory in vitro action on mammalian cell cultures also suggest a possible positive effect on hu...
  17. Resveratrol and the pharmacology of aging: a new vertebrate model to validate an old molecule.

    Cell Cycle 5(10):1027 (2006) PMID 16687936

    The natural phytoalexin resveratrol, found in grapes and red wine, recently rose to public fame for its positive effects on longevity in yeasts, worms and flies. Resveratrol anti-cancer and anti-inflammatory in vitro action on mammalian cell cultures also suggest a possible positive effect on hu...
  18. Shape analysis of female facial attractiveness.

    Vision Research 46(8-9):1282 (2006) PMID 16356527

    Previous studies have suggested that female facial attractiveness is associated with exaggerated sex-specific facial traits and averageness. Here we applied geometric morphometrics, a method for multivariate statistical analysis of shape, to measure geometric averageness and geometric sexual dim...
  19. Shape analysis of female facial attractiveness.

    Vision Research 46(8-9):1282 (2006) PMID 16356527

    Previous studies have suggested that female facial attractiveness is associated with exaggerated sex-specific facial traits and averageness. Here we applied geometric morphometrics, a method for multivariate statistical analysis of shape, to measure geometric averageness and geometric sexual dim...
  20. Shape analysis of female facial attractiveness

    Vision Research 46(8):1282 (2006)

    Previous studies have suggested that female facial attractiveness is associated with exaggerated sex-specific facial traits and averageness. Here we applied geometric morphometrics, a method for multivariate statistical analysis of shape, to measure geometric averageness and geometric sexua...