1. MTBP inhibits migration and metastasis of hepatocellular carcinoma.

    Clinical & Experimental Metastasis 32(4):301 (2015) PMID 25759210 PMCID PMC4510982

    Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with increasing incidence. Despite curative surgical resection and advanced chemotherapy, its survival rate remains low. The presence of microvascular invasion and occult metastasis is one of the major causes for this poo...
  2. Microenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell's Journey.

    Cancer Microenvironment 7(3):117 (2014) PMID 24938990 PMCID PMC4275500

    Metastasis is the process of primary tumor cells breaking away and colonizing distant secondary sites. In order for a tumor cell growing in one microenvironment to travel to, and flourish in, a secondary environment, it must survive a series of events termed the metastatic cascade. Before depart...
  3. Microenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell's Journey.

    Cancer Microenvironment 7(3):117 (2014) PMID 24938990

    Metastasis is the process of primary tumor cells breaking away and colonizing distant secondary sites. In order for a tumor cell growing in one microenvironment to travel to, and flourish in, a secondary environment, it must survive a series of events termed the metastatic cascade. Before depart...
  4. Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix.

    Molecular Carcinogenesis 53(12):1011 (2014) PMID 24000122 PMCID PMC3939074

    Metastatic dissemination is a multi-step process that depends on cancer cells' ability to respond to microenvironmental cues by adapting adhesion abilities and undergoing cytoskeletal rearrangement. Breast Cancer Metastasis Suppressor 1 (BRMS1) affects several steps of the metastatic cascade: it...
  5. Microenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell's Journey.

    Cancer Microenvironment 7(3):117 (2014) PMID 24938990 PMCID PMC4275500

    Metastasis is the process of primary tumor cells breaking away and colonizing distant secondary sites. In order for a tumor cell growing in one microenvironment to travel to, and flourish in, a secondary environment, it must survive a series of events termed the metastatic cascade. Before depart...
  6. Microenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell's Journey.

    Cancer Microenvironment 7(3):117 (2014) PMID 24938990

    Metastasis is the process of primary tumor cells breaking away and colonizing distant secondary sites. In order for a tumor cell growing in one microenvironment to travel to, and flourish in, a secondary environment, it must survive a series of events termed the metastatic cascade. Before depart...
  7. Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix.

    Molecular Carcinogenesis 53(12):1011 (2014) PMID 24000122 PMCID PMC3939074

    Metastatic dissemination is a multi-step process that depends on cancer cells' ability to respond to microenvironmental cues by adapting adhesion abilities and undergoing cytoskeletal rearrangement. Breast Cancer Metastasis Suppressor 1 (BRMS1) affects several steps of the metastatic cascade: it...
  8. Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix.

    Molecular Carcinogenesis 53(12):1011 (2014) PMID 24000122 PMCID PMC3939074

    Metastatic dissemination is a multi-step process that depends on cancer cells' ability to respond to microenvironmental cues by adapting adhesion abilities and undergoing cytoskeletal rearrangement. Breast Cancer Metastasis Suppressor 1 (BRMS1) affects several steps of the metastatic cascade: it...
  9. Imaging of epidermal growth factor receptor on single breast cancer cells using surface-enhanced Raman spectroscopy.

    Analytica Chimica Acta 843:73 (2014) PMID 25150698 PMCID PMC4167599

    Epidermal growth factor receptor (EGFR) is widely used as a biomarker for pathological grading and therapeutic targeting of human cancers. This study investigates expression, spatial distribution as well as the endocytosis of EGFR in single breast cancer cells using surface-enhanced Raman spectr...
  10. Imaging of epidermal growth factor receptor on single breast cancer cells using surface-enhanced Raman spectroscopy.

    Analytica Chimica Acta 843:73 (2014) PMID 25150698 PMCID PMC4167599

    Epidermal growth factor receptor (EGFR) is widely used as a biomarker for pathological grading and therapeutic targeting of human cancers. This study investigates expression, spatial distribution as well as the endocytosis of EGFR in single breast cancer cells using surface-enhanced Raman spectr...
  11. Toward a drug development path that targets metastatic progression in osteosarcoma.

    Clinical Cancer Research 20(16):4200 (2014) PMID 24803583 PMCID PMC4134738

    Despite successful primary tumor treatment, the development of pulmonary metastasis continues to be the most common cause of mortality in patients with osteosarcoma. A conventional drug development path requiring drugs to induce regression of established lesions has not led to improvements for p...
  12. Toward a drug development path that targets metastatic progression in osteosarcoma.

    Clinical Cancer Research 20(16):4200 (2014) PMID 24803583 PMCID PMC4134738

    Despite successful primary tumor treatment, the development of pulmonary metastasis continues to be the most common cause of mortality in patients with osteosarcoma. A conventional drug development path requiring drugs to induce regression of established lesions has not led to improvements for p...
  13. Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas.

    Clinical & Experimental Metastasis 31(5):497 (2014) PMID 24570268 PMCID PMC4065802

    The expression and biological consequences of Kaiso, a novel bi-modal transcription factor, in infiltrating ductal carcinomas (IDCs) have not been widely investigated. In the present study, we determined Kaiso expression and subcellular localization in 146 normal tissues, 376 IDCs, and 85 lymph ...
  14. Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas.

    Clinical & Experimental Metastasis 31(5):497 (2014) PMID 24570268 PMCID PMC4065802

    The expression and biological consequences of Kaiso, a novel bi-modal transcription factor, in infiltrating ductal carcinomas (IDCs) have not been widely investigated. In the present study, we determined Kaiso expression and subcellular localization in 146 normal tissues, 376 IDCs, and 85 lymph ...
  15. Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas.

    Clinical & Experimental Metastasis 31(5):497 (2014) PMID 24570268 PMCID PMC4065802

    The expression and biological consequences of Kaiso, a novel bi-modal transcription factor, in infiltrating ductal carcinomas (IDCs) have not been widely investigated. In the present study, we determined Kaiso expression and subcellular localization in 146 normal tissues, 376 IDCs, and 85 lymph ...
  16. Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.

    Cancer Research 74(3):954 (2014) PMID 24351292 PMCID PMC3946400

    Cancer cells tend to utilize aerobic glycolysis even under normoxic conditions, commonly called the "Warburg effect." Aerobic glycolysis often directly correlates with malignancy, but its purpose, if any, in metastasis remains unclear. When wild-type KISS1 metastasis suppressor is expressed, aer...
  17. Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.

    Cancer Research 74(3):954 (2014) PMID 24351292 PMCID PMC3946400

    Cancer cells tend to utilize aerobic glycolysis even under normoxic conditions, commonly called the "Warburg effect." Aerobic glycolysis often directly correlates with malignancy, but its purpose, if any, in metastasis remains unclear. When wild-type KISS1 metastasis suppressor is expressed, aer...
  18. Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.

    Cancer Research 74(3):954 (2014) PMID 24351292 PMCID PMC3946400

    Cancer cells tend to utilize aerobic glycolysis even under normoxic conditions, commonly called the "Warburg effect." Aerobic glycolysis often directly correlates with malignancy, but its purpose, if any, in metastasis remains unclear. When wild-type KISS1 metastasis suppressor is expressed, aer...
  19. Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.

    Cancer Research 74(3):954 (2014) PMID 24351292 PMCID PMC3946400

    Cancer cells tend to utilize aerobic glycolysis even under normoxic conditions, commonly called the "Warburg effect." Aerobic glycolysis often directly correlates with malignancy, but its purpose, if any, in metastasis remains unclear. When wild-type KISS1 metastasis suppressor is expressed, aer...
  20. Metastasis suppressors in breast cancers: mechanistic insights and clinical potential.

    Klinische Wochenschrift 92(1):13 (2014) PMID 24311119 PMCID PMC3923422

    For the most part, normal epithelial cells do not disseminate to other parts of the body and proliferate, as do metastatic cells. Presumably, a class of molecules-termed metastasis suppressors-are involved in this homeostatic control. Metastasis suppressors are, by definition, cellular factors t...