1. Revisiting the mechanistic basis of the French Paradox: Red wine inhibits the activity of protein disulfide isomerase in vitro.

    Thrombosis Research 137:169 (2016) PMID 26585763 PMCID PMC4706467

    Although epidemiologic evidence points to cardioprotective activity of red wine, the mechanistic basis for antithrombotic activity has not been established. Quercetin and related flavonoids are present in high concentrations in red but not white wine. Quercetin-glycosides were recently shown to ...
  2. A novel application of radiomimetic compounds as antibiotic drugs.

    Journal of Pharmacy and Pharmacology 67(10):1371 (2015) PMID 25920505

    This study aims to examine the potential of radiomimetic compounds as antimicrobial therapeutics, as the recent advances in radiomimetic targeting as well as rapid increase of multidrug resistant bacteria make these compounds attractive for future development. Representative radiomimetics from e...
  3. The Role and Responsibilities of Pharmacy Student Government Associations in Pharmacy Programs.

    American Journal of Pharmaceutical Education 79(7):100 (2015) PMID 27168613 PMCID PMC4812776

    Objective. To identify student government designs used by pharmacy programs and to examine their functions, duties, and relationships with other student organizations. Methods. A 21-question survey was developed and distributed to pharmacy deans, who were asked to forward the survey to the leade...
  4. Comparison of Introductory Pharmacy Practice Experiences Among US Pharmacy Programs.

    American Journal of Pharmaceutical Education 78(9):162 (2014) PMID 26056401 PMCID PMC4453079

    To identify the various IPPE designs utilized by US pharmacy programs. A 20-question survey was developed and distributed to experiential affairs professionals at 129 pharmacy institutions nationwide addressing school demographics and IPPE design. Results were analyzed in aggregate. Ninety-three...
  5. The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance.

    DNA Repair 21:165 (2014) PMID 24986640 PMCID PMC4126566

    The ability of the radiomimetic anti-tumor enediyne C-1027 to induce DNA inter-strand crosslinks (ICLs), in addition to the expected DNA strand breaks, is unique among traditional DNA targeted cancer therapies. Importantly, radiation therapy and most radiomimetic drugs have diminished effect in ...
  6. Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins.

    Blood 120(3):647 (2012) PMID 22653978 PMCID PMC3401216

    Extracellular protein disulfide isomerase (PDI) is required for platelet thrombus formation and fibrin generation after arteriolar wall injury in live mice. PDI is secreted from platelets and endothelial cells on cellular activation, but the mechanism of capture of secreted PDI within the injure...
  7. Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents.

    Journal of Clinical Investigation 122(6):2104 (2012) PMID 22565308 PMCID PMC3366406

    Thrombosis, or blood clot formation, and its sequelae remain a leading cause of morbidity and mortality, and recurrent thrombosis is common despite current optimal therapy. Protein disulfide isomerase (PDI) is an oxidoreductase that has recently been shown to participate in thrombus formation. W...
  8. Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses.

    PNAS 104(45):17632 (2007) PMID 17978180 PMCID PMC2077023

    The ability of the radiomimetic anticancer enediyne C-1027 to induce ataxia-telangiectasia mutated (ATM) and ATM and Rad3-related (ATR)-independent damage responses was discovered to reside in its unique ability to concurrently generate robust amounts of double-strand breaks (DSBs) and interstra...
  9. Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks.

    Cancer Research 67(2):773 (2007) PMID 17234789

    The radiomimetic enediyne C-1027 induces almost exclusively DNA double-strand breaks (DSB) and is extremely cytotoxic. Unique among radiomimetics, ataxia-telangiectasia mutated (ATM) is dispensable for cellular responses to C-1027-induced DNA damage. This study explores the biological activity o...
  10. The radiomimetic enediyne C-1027 induces unusual DNA damage responses to double-strand breaks.

    Biochemistry (Washington) 45(11):3747 (2006) PMID 16533058 PMCID PMC2504721

    Cells lacking the protein kinase ataxia telangiectasia mutated (ATM) have defective responses to DNA double-strand breaks (DSBs), including an inability to activate damage response proteins such as p53. However, we previously showed that cells lacking ATM robustly activate p53 in response to DNA...
  11. Structure-activity analysis of taxane-based broad-spectrum multidrug resistance modulators.

    Anticancer Research 24(2A):409 (2004) PMID 15152938

    Clinical drug resistance is frequently associated with overexpression of the multidrug resistance (MDR) proteins P-glycoprotein (Pgp), multidrug resistance protein (MRP-1) and breast cancer resistance protein (BCRP). Taxanes are substrates for Pgp and MRP-1, but not BCRP. Taxane-based reversal a...