1. Endogenous neural stem/progenitor cells stabilize the cortical microenvironment after traumatic brain injury.

    Journal of Neurotrauma 32(11):753 (2015) PMID 25290253 PMCID PMC4449704

    Although a myriad of pathological responses contribute to traumatic brain injury (TBI), cerebral dysfunction has been closely linked to cell death mechanisms. A number of therapeutic strategies have been studied in an attempt to minimize or ameliorate tissue damage; however, few studies have eva...
  2. Pronounced hypoxia in the subventricular zone following traumatic brain injury and the neural stem/progenitor cell response.

    Experimental Biology and Medicine 238(7):830 (2013) PMID 23828590

    Traumatic brain injury (TBI) elicits identifiable changes within the adult subventricular zone (SVZ). Previously, we demonstrated that EphB3/ephrinB3 interaction inhibits neural stem/progenitor cell (NSPC) proliferation and downregulating this pathway following TBI plays a pivotal role in the ex...
  3. Pronounced hypoxia in the subventricular zone following traumatic brain injury and the neural stem/progenitor cell response.

    Experimental Biology and Medicine 238(7):830 (2013) PMID 23828590

    Traumatic brain injury (TBI) elicits identifiable changes within the adult subventricular zone (SVZ). Previously, we demonstrated that EphB3/ephrinB3 interaction inhibits neural stem/progenitor cell (NSPC) proliferation and downregulating this pathway following TBI plays a pivotal role in the ex...
  4. Reduced extracellular zinc levels facilitate glutamate-mediated oligodendrocyte death after trauma.

    Journal of Neuroscience Research 91(6):828 (2013) PMID 23553703 PMCID PMC4120886

    Spinal cord injury results in irreversible paralysis, axonal injury, widespread oligodendrocyte death, and white matter damage. Although the mechanisms underlying these phenomena are poorly understood, previous studies from our laboratory indicate that inhibiting activation of the nuclear factor...
  5. Reduced extracellular zinc levels facilitate glutamate-mediated oligodendrocyte death after trauma.

    Journal of Neuroscience Research 91(6):828 (2013) PMID 23553703 PMCID PMC4120886

    Spinal cord injury results in irreversible paralysis, axonal injury, widespread oligodendrocyte death, and white matter damage. Although the mechanisms underlying these phenomena are poorly understood, previous studies from our laboratory indicate that inhibiting activation of the nuclear factor...
  6. Effects of early rolipram treatment on histopathological outcome after controlled cortical impact injury in mice.

    Neuroscience Letters 532:1 (2013) PMID 23103712 PMCID PMC3527646

    Traumatic brain injury (TBI) pathology includes contusions, cavitation, cell death, all of which can be exacerbated by inflammation. We hypothesized that an anti-inflammatory drug, rolipram, may reduce pathology after TBI, since in several CNS injury models rolipram reduces inflammation and impr...
  7. Effects of early rolipram treatment on histopathological outcome after controlled cortical impact injury in mice.

    Neuroscience Letters 532:1 (2013) PMID 23103712 PMCID PMC3527646

    Traumatic brain injury (TBI) pathology includes contusions, cavitation, cell death, all of which can be exacerbated by inflammation. We hypothesized that an anti-inflammatory drug, rolipram, may reduce pathology after TBI, since in several CNS injury models rolipram reduces inflammation and impr...
  8. High-content analysis of proapoptotic EphA4 dependence receptor functions using small-molecule libraries.

    Journal of Biomolecular Screening 17(6):785 (2012) PMID 22492230

    Small-molecule compounds (SMCs) can provide an inexpensive and selective approach to modifying biological responses. High-content analysis (HCA) of SMC libraries can help identify candidate molecules that inhibit or activate cellular responses. In particular, regulation of cell death has importa...
  9. High-content analysis of proapoptotic EphA4 dependence receptor functions using small-molecule libraries.

    Journal of Biomolecular Screening 17(6):785 (2012) PMID 22492230

    Small-molecule compounds (SMCs) can provide an inexpensive and selective approach to modifying biological responses. High-content analysis (HCA) of SMC libraries can help identify candidate molecules that inhibit or activate cellular responses. In particular, regulation of cell death has importa...
  10. High-content analysis of proapoptotic EphA4 dependence receptor functions using small-molecule libraries.

    Journal of Biomolecular Screening 17(6):785 (2012) PMID 22492230 PMCID PMC4380140

    Small-molecule compounds (SMCs) can provide an inexpensive and selective approach to modifying biological responses. High-content analysis (HCA) of SMC libraries can help identify candidate molecules that inhibit or activate cellular responses. In particular, regulation of cell death has importa...
  11. Nuclear factor-κB activation in Schwann cells regulates regeneration and remyelination.

    Glia 60(4):639 (2012) PMID 22275133 PMCID PMC4120893

    Schwann cells (SCs) are crucial for peripheral nerve development and regeneration; however, the intrinsic regulatory mechanisms governing postinjury responses are poorly understood. Activation and deacetylation of nuclear factor-κB (NF- κB) in SCs have been implicated as prerequisites for periph...
  12. Nuclear factor-κB activation in Schwann cells regulates regeneration and remyelination.

    Glia 60(4):639 (2012) PMID 22275133 PMCID PMC4120893

    Schwann cells (SCs) are crucial for peripheral nerve development and regeneration; however, the intrinsic regulatory mechanisms governing postinjury responses are poorly understood. Activation and deacetylation of nuclear factor-κB (NF- κB) in SCs have been implicated as prerequisites for periph...
  13. Reproducible expansion and characterization of mouse neural stem/progenitor cells in adherent cultures derived from the adult subventricular zone.

    Current protocols in stem cell biology Chapter 2:Unit 2D.8 (2012) PMID 22415840 PMCID PMC3312298

    Endogenous neural stem/progenitor cells (NSPCs) residing in the subventricular zone (SVZ) of the adult mouse forebrain have been shown to enhance their neurogenic potential in response to CNS injury. Mechanisms involved in regulating adult neurogenesis under naïve or stressed conditions can be s...
  14. Reproducible expansion and characterization of mouse neural stem/progenitor cells in adherent cultures derived from the adult subventricular zone.

    Current protocols in stem cell biology Chapter 2:Unit 2D.8 (2012) PMID 22415840 PMCID PMC3312298

    Endogenous neural stem/progenitor cells (NSPCs) residing in the subventricular zone (SVZ) of the adult mouse forebrain have been shown to enhance their neurogenic potential in response to CNS injury. Mechanisms involved in regulating adult neurogenesis under naïve or stressed conditions can be s...
  15. Reproducible expansion and characterization of mouse neural stem/progenitor cells in adherent cultures derived from the adult subventricular zone.

    Current protocols in stem cell biology Chapter 2:Unit 2D.8 (2012) PMID 22415840 PMCID PMC3312298

    Endogenous neural stem/progenitor cells (NSPCs) residing in the subventricular zone (SVZ) of the adult mouse forebrain have been shown to enhance their neurogenic potential in response to CNS injury. Mechanisms involved in regulating adult neurogenesis under naïve or stressed conditions can be s...
  16. Eph signaling regulates gliotransmitter release.

    Communicative & Integrative Biology 4(2):223 (2011) PMID 21655447 PMCID PMC3104586

    Astrocytes have been recently identified as important components of the tripartite synaptic complex. There is growing evidence that astrocytes regulate synaptic functions, in part, through the release of gliotransmitters. In a recent study, we have demonstrated that ephrinB3 could stimulate astr...
  17. Eph signaling regulates gliotransmitter release.

    Communicative & Integrative Biology 4(2):223 (2011) PMID 21655447 PMCID PMC3104586

    Astrocytes have been recently identified as important components of the tripartite synaptic complex. There is growing evidence that astrocytes regulate synaptic functions, in part, through the release of gliotransmitters. In a recent study, we have demonstrated that ephrinB3 could stimulate astr...
  18. Neural progenitors proliferation is inhibited by EphB3 in the developing subventricular zone.

    International Journal of Developmental Neurosci... 29(1):9 (2011) PMID 20969945 PMCID PMC3004986

    The subventricular zone (SVZ) of the mammalian forebrain is a major source of multipotent stem cells during development, and contributes to neurogenesis throughout the lifespan of the organism. Several studies described molecules regulating adult neurogenesis, however, few of them have examined ...
  19. Neural progenitors proliferation is inhibited by EphB3 in the developing subventricular zone.

    International Journal of Developmental Neurosci... 29(1):9 (2011) PMID 20969945 PMCID PMC3004986

    The subventricular zone (SVZ) of the mammalian forebrain is a major source of multipotent stem cells during development, and contributes to neurogenesis throughout the lifespan of the organism. Several studies described molecules regulating adult neurogenesis, however, few of them have examined ...
  20. Neural progenitors proliferation is inhibited by EphB3 in the developing subventricular zone

    International Journal of Developmental Neurosci... 29(1):9 (2011)

    Research highlights ▶ EphB3 regulates proliferation in the neonatal subventricular zone. ▶ EphB3 −/− neural progenitors proliferate more in culture. ▶ Cell death is unchanged in the neonatal EphB3 −/− SVZ, unlike the adult.