1. Case records of the Massachusetts General Hospital. Case 12-2015. A newborn boy with respiratory distress, lethargy, and hypernatremia.

    New England Journal of Medicine 372(16):1550 (2015) PMID 25875261

  2. VE1 antibody immunoreactivity in normal anterior pituitary and adrenal cortex without detectable BRAF V600E mutations.

    American Journal of Clinical Pathology 141(6):811 (2014) PMID 24838325

    The VE1 monoclonal antibody was developed to recognize the V600E mutation in BRAF, which is found in various tumors. We report that the VE1 antibody stains normal anterior pituitary gland and adrenal cortex, which lack detectable BRAF V600E mutations. Staining with the VE1 antibody was seen in t...
  3. VE1 antibody immunoreactivity in normal anterior pituitary and adrenal cortex without detectable BRAF V600E mutations.

    American Journal of Clinical Pathology 141(6):811 (2014) PMID 24838325

    The VE1 monoclonal antibody was developed to recognize the V600E mutation in BRAF, which is found in various tumors. We report that the VE1 antibody stains normal anterior pituitary gland and adrenal cortex, which lack detectable BRAF V600E mutations. Staining with the VE1 antibody was seen in t...
  4. Glioblastoma mimicking an arteriovenous malformation.

    Frontiers in Neurology 4:144 (2013) PMID 24137154 PMCID PMC3786388

    Abnormal cerebral vasculature can be a manifestation of a vascular malformation or a neoplastic process. We report the case of a patient with angiography-negative subarachnoid hemorrhage (SAH) who re-presented 3 years later with a large intraparenchymal hemorrhage. Although imaging following the...
  5. Glioblastoma mimicking an arteriovenous malformation.

    Frontiers in Neurology 4:144 (2013) PMID 24137154 PMCID PMC3786388

    Abnormal cerebral vasculature can be a manifestation of a vascular malformation or a neoplastic process. We report the case of a patient with angiography-negative subarachnoid hemorrhage (SAH) who re-presented 3 years later with a large intraparenchymal hemorrhage. Although imaging following the...
  6. Cytopathology of subacute thyroiditis.

    Diagnostic Cytopathology 40(5):433 (2012) PMID 22045514

  7. Cytopathology of subacute thyroiditis.

    Diagnostic Cytopathology 40(5):433 (2012) PMID 22045514

  8. A workshop on leadership for MD/PhD students.

    Medical Education Online 16 (2011) PMID 21841905 PMCID PMC3154680

    Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to ...
  9. A workshop on leadership for MD/PhD students.

    Medical Education Online 16 (2011) PMID 21841905 PMCID PMC3154680

    Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to ...
  10. Dpb11 activates the Mec1-Ddc2 complex.

    PNAS 105(48):18730 (2008) PMID 19028869 PMCID PMC2596233

    The Saccharomyces cerevisiae Mec1-Ddc2 checkpoint kinase complex (the ortholog to human ATR-ATRIP) is an essential regulator of genomic integrity. The S. cerevisiae BRCT repeat protein Dpb11 functions in the initiation of both DNA replication and cell cycle checkpoints. Here, we report a genetic...
  11. Dpb11 activates the Mec1-Ddc2 complex.

    PNAS 105(48):18730 (2008) PMID 19028869 PMCID PMC2596233

    The Saccharomyces cerevisiae Mec1-Ddc2 checkpoint kinase complex (the ortholog to human ATR-ATRIP) is an essential regulator of genomic integrity. The S. cerevisiae BRCT repeat protein Dpb11 functions in the initiation of both DNA replication and cell cycle checkpoints. Here, we report a genetic...
  12. The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.

    Molecular and Cellular Biology 28(24):7345 (2008) PMID 18936170 PMCID PMC2593429

    ATR kinase activation requires the recruitment of the ATR-ATRIP and RAD9-HUS1-RAD1 (9-1-1) checkpoint complexes to sites of DNA damage or replication stress. Replication protein A (RPA) bound to single-stranded DNA is at least part of the molecular recognition element that recruits these checkpo...
  13. The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.

    Molecular and Cellular Biology 28(24):7345 (2008) PMID 18936170 PMCID PMC2593429

    ATR kinase activation requires the recruitment of the ATR-ATRIP and RAD9-HUS1-RAD1 (9-1-1) checkpoint complexes to sites of DNA damage or replication stress. Replication protein A (RPA) bound to single-stranded DNA is at least part of the molecular recognition element that recruits these checkpo...
  14. Activation of ATR and related PIKKs.

    Cell Cycle 7(18):2809 (2008) PMID 18769153 PMCID PMC2672405

    The DNA damage response kinase ATR is an essential regulator of genome integrity. TopBP1 functions as a general activator of ATR. We have recently shown that TopBP1 activates ATR through its regulatory subunit ATRIP and a PIKK regulatory domain (PRD) located adjacent to its kinase domain. This m...
  15. Activation of ATR and related PIKKs.

    Cell Cycle 7(18):2809 (2008) PMID 18769153 PMCID PMC2672405

    The DNA damage response kinase ATR is an essential regulator of genome integrity. TopBP1 functions as a general activator of ATR. We have recently shown that TopBP1 activates ATR through its regulatory subunit ATRIP and a PIKK regulatory domain (PRD) located adjacent to its kinase domain. This m...
  16. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.

    Genes & Development 22(11):1478 (2008) PMID 18519640 PMCID PMC2418584

    The ATR (ATM and Rad3-related) kinase and its regulatory partner ATRIP (ATR-interacting protein) coordinate checkpoint responses to DNA damage and replication stress. TopBP1 functions as a general activator of ATR. However, the mechanism by which TopBP1 activates ATR is unknown. Here, we show th...
  17. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.

    Genes & Development 22(11):1478 (2008) PMID 18519640 PMCID PMC2418584

    The ATR (ATM and Rad3-related) kinase and its regulatory partner ATRIP (ATR-interacting protein) coordinate checkpoint responses to DNA damage and replication stress. TopBP1 functions as a general activator of ATR. However, the mechanism by which TopBP1 activates ATR is unknown. Here, we show th...
  18. Function of a conserved checkpoint recruitment domain in ATRIP proteins.

    Molecular and Cellular Biology 27(9):3367 (2007) PMID 17339343 PMCID PMC1899971

    The ATR (ATM and Rad3-related) kinase is essential to maintain genomic integrity. ATR is recruited to DNA lesions in part through its association with ATR-interacting protein (ATRIP), which in turn interacts with the single-stranded DNA binding protein RPA (replication protein A). In this study,...
  19. Function of a conserved checkpoint recruitment domain in ATRIP proteins.

    Molecular and Cellular Biology 27(9):3367 (2007) PMID 17339343 PMCID PMC1899971

    The ATR (ATM and Rad3-related) kinase is essential to maintain genomic integrity. ATR is recruited to DNA lesions in part through its association with ATR-interacting protein (ATRIP), which in turn interacts with the single-stranded DNA binding protein RPA (replication protein A). In this study,...