1. Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

    Cell 160(5):928 (2015)

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cyc...
  2. Early telomerase inactivation accelerates aging independently of telomere length.

    Cell 160(5):928 (2015) PMID 25723167

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cycle dynamic...
  3. Early telomerase inactivation accelerates aging independently of telomere length.

    Cell 160(5):928 (2015) PMID 25723167 PMCID PMC4496004

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cycle dynamic...
  4. Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

    Cell (2014)

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even Early after Telomerase Inactivation (ETI), yeast mother cells show transient DNA Damage Response (DDR) episodes, stochastically altered cell cyc...
  5. Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.

    Genes & Development 22(7):854 (2008) PMID 18334620 PMCID PMC2279195

    The kinases ATM and ATR (Tel1 and Mec1 in the yeast Saccharomyces cerevisiae) control the response to DNA damage. We report that S. cerevisiae Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling. We show that Tel1 and Tel2 interact, and that even when Tel1 protein levels a...
  6. Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.

    Genes & Development 22(7):854 (2008) PMID 18334620 PMCID PMC2279195

    The kinases ATM and ATR (Tel1 and Mec1 in the yeast Saccharomyces cerevisiae) control the response to DNA damage. We report that S. cerevisiae Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling. We show that Tel1 and Tel2 interact, and that even when Tel1 protein levels a...
  7. Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response.

    Molecular Biology of the Cell 15(4):1623 (2004) PMID 14742705 PMCID PMC379261

    Mutation of the template region in the RNA component of telomerase can cause incorporation of mutant DNA sequences at telomeres. We made all 63 mutant sequence combinations at template positions 474-476 of the yeast telomerase RNA, TLC1. Mutants contained faithfully incorporated template mutatio...
  8. Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response.

    Molecular Biology of the Cell 15(4):1623 (2004) PMID 14742705 PMCID PMC379261

    Mutation of the template region in the RNA component of telomerase can cause incorporation of mutant DNA sequences at telomeres. We made all 63 mutant sequence combinations at template positions 474-476 of the yeast telomerase RNA, TLC1. Mutants contained faithfully incorporated template mutatio...
  9. Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

    Cell (2001)

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cyc...
  10. Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

    Cell (2001)

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cyc...
  11. Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

    Cell (2001)

    Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cyc...
  12. A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an α2 dimer

    Cell 68(1):133 (1992)

    DNA recognition sequences for dimeric proteins typically contain two types of information. The first is the DNA sequence of each half-site, and the second is the arrangement of these half-sites. We show that dimers of the yeast homeodomain protein α2, although able to read the first type of...