Dietary high cholesterol and trace metals in the drinking water increase levels of ABCA1 in the rabbit hippocampus and temporal cortex.
Journal of Alzheimer's Disease 49(1):201 (2015)
Cholesterol-fed rabbits have been documented to show increased amyloid-β (Aβ) deposits in the brain that can be exacerbated by the quality of drinking water especially if rabbits drink tap water or distilled water containing copper. One mechanism of cholesterol and Aβ clearance may be through th...
KIF6 719Arg allele is associated with statin effects on cholesterol levels in amnestic mild cognitive impairment and Alzheimer's disease patients.
Journal of Alzheimer's Disease 33(1):111 (2013)
KIF6 719Arg allele carriers are thought to have a greater lipid lowering response from statin therapy than non-carriers. Given the continued interest in the relationship between cholesterol, statin use, amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD), investigating the ro...
Cholesterol increases ventricular volume in a rabbit model of Alzheimer's disease.
Journal of Alzheimer's Disease 29(2):283 (2012)
One of the hallmarks of Alzheimer's disease is a significant increase in ventricular volume. To date we and others have shown that a cholesterol-fed rabbit model of Alzheimer's disease displays as many as fourteen different pathological markers of Alzheimer's disease including amyloid-β accumula...
Tau is reduced in AD plasma and validation of employed ELISA methods.
American Journal of Neurodegenerative Disease 1(1):99 (2012)
Measure total tau levels in the circulation of living humans, validate the methods employed and determine if there are consistent differences in total tau levels between normal controls and individuals with mild cognitive impairment (MCI) and/or Alzheimer's disease (AD).
Employing ELISA methods,...
Statins to treat Alzheimer's disease: an incomplete story.
Expert Review of Neurotherapeutics 12(1):27 (2012)
The link between cholesterol and Alzheimer's disease (AD) has been explored for almost two decades. The link stems from the observation that atherosclerotic heart disease increases the risk for AD and that people expiring from coronary artery disease had AD changes in their brains. Cholesterol i...
Alzheimer disease: statins in the treatment of Alzheimer disease.
Nature Clinical Practice Neurology 7(12):662 (2011)
Influence of water quality on cholesterol-induced tau pathology: preliminary data.
International Journal of Alzheimer's Disease 2011:987023 (2011)
The studies employed the cholesterol-fed rabbit model of Alzheimer's disease (AD) to investigate the relationship between AD-like neurofibrillary tangle (NFT) neuropathology and tau protein levels as the main component of NFT. We measured brain and plasma tau levels and semiquantified NFT-like n...
Copper status in Alzheimer's disease and other neurodegenerative disorders: genetics, mechanisms, neurophysiology, and therapies.
International Journal of Alzheimer's Disease 2011:903940 (2011)
Neurovascular changes measured by time-of-flight MR angiography in cholesterol-fed rabbits with cortical amyloid beta-peptide accumulation.
Journal of Magnetic Resonance Imaging 32(2):306 (2010)
To test the hypothesis that narrowing of cranial blood vessels in cholesterol-fed rabbits is a function of the duration of the high cholesterol diet. Such neurovascular changes, caused by elevated serum cholesterol, are linked to stroke and Alzheimer's disease risk.
Four groups of New Zealand Wh...
Cholesterol and cognitive performance in normal controls and the influence of elective statin use after conversion to mild cognitive impairment: results in a clinical trial cohort.
Neurodegenerative Diseases 7(1-3):183 (2010)
We reported a significant 67% reduction in the hazard risk of incident Alzheimer's disease (AD) with elective statin use in the AD Anti-inflammatory Prevention Trial (ADAPT), without a reduction in risk of incident mild cognitive impairment (MCI).
To assess if cholesterol levels are associated w...
Angiotensin I-converting enzyme I/D polymorphism and suicidal behaviors.
American Journal of Medical Genetics. Part B: N... 150B(2):290 (2009)
Suicide is one of the ten most common causes of death in Western countries. It involves genetic vulnerability factors and is often associated with major depression. A Japanese team reported an association between the insertion allele of the angiotensin-converting enzyme (ACE) gene insertion/dele...
The early and ongoing experience with the cholesterol-fed rabbit as a model of Alzheimer's disease: the old, the new and the pilot.
Journal of Alzheimer's Disease 15(4):641 (2008)
Pioneering autopsy studies revealed a possible link between coronary artery disease, cholesterol and Alzheimer's disease (AD). In the cholesterol-fed rabbit model of human coronary artery disease, we identified numerous neuropathologic features of AD including central accumulation of amyloid-bet...
Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity.
Glia 56(10):1048 (2008)
Degeneration of microglial cells may be important for understanding the pathogenesis of aging-related neurodegeneration and neurodegenerative diseases. In this study, we analyzed the morphological characteristics of microglial cells in the nondemented and Alzheimer's disease (AD) human brain usi...
Reduced risk of incident AD with elective statin use in a clinical trial cohort.
Current Alzheimer Research 5(4):416 (2008)
Statins have been reported to reduce the risk and be of benefit in the treatment of Alzheimer's disease (AD). Individuals enrolling in the randomized controlled trial testing two anti-inflammatory agents for primary prevention of AD (Alzheimer's Disease Anti-inflammatory Prevention Trial; ADAPT)...
Hippocampal volume change in the Alzheimer Disease Cholesterol-Lowering Treatment trial.
Cleveland Clinic Journal of Medicine 75 Suppl 2:S87 (2008)
Numerous clinical studies suggest a link between elevated cholesterol and increased risk of Alzheimer disease (AD), and the preponderance of data suggests that statin therapy may reduce the risk of AD later in life. The first clinical investigation of statin therapy in patients with AD, the AD C...
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins.
Nature Medicine 13(11):1359 (2007)
A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impa...
Cholesterol enhances classical conditioning of the rabbit heart rate response.
Behavioural Brain Research 181(1):52 (2007)
The cholesterol-fed rabbit is a model of atherosclerosis and has been proposed as an animal model of Alzheimer's disease. Feeding rabbits cholesterol has been shown to increase the number of beta amyloid immunoreactive neurons in the cortex. Addition of copper to the drinking water of cholestero...
Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Abeta through the liver.
Current Alzheimer Research 4(2):165 (2007)
Mounting evidence suggests that copper may influence the progression of Alzheimer's disease by reducing clearance of the amyloid beta protein (Ass) from the brain. We propose that Abeta is cleared from the brain by tagging along with cholesterol/ApoE in traversing the BBB, with subsequent incorp...
High dietary cholesterol facilitates classical conditioning of the rabbit's nictitating membrane response.
Nutritional Neuroscience 10(1-2):31 (2007)
Studies have shown that modifying dietary cholesterol may improve learning and that serum cholesterol levels can be positively correlated with cognitive performance. Rabbits fed a 0, 0.5, 1 or 2% cholesterol diet for eight weeks and 0.12 ppm copper added to their drinking water received trace an...
Classical conditioning of the rabbit's nictitating membrane response is a function of the duration of dietary cholesterol.
Nutritional Neuroscience 10(3-4):159 (2007)
Modifying dietary cholesterol may improve learning and memory but very high cholesterol can cause pathophysiology and death. Rabbits fed 2% cholesterol for 8, 10 or 12 weeks with 0.12 ppm copper added to distilled water and rabbits fed a normal diet without copper added to distilled water (0 wee...