1. Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury.

    Biochemical and Biophysical Research Communicat... 476(4):346 (2016) PMID 27235555 PMCID PMC4935552

    Supplemental oxygen, which is routinely administered to preterm infants with pulmonary insufficiency, contributes to bronchopulmonary dysplasia (BPD) in these infants. Hyperoxia also contributes to the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in adult...
  2. In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin.

    Methods in Molecular Biology 1395:55 (2016) PMID 26910068

    Cancer is the second leading cause of mortality worldwide; however the response rate to chemotherapy treatment remains slow, mainly due to narrow therapeutic index and multidrug resistance. Paclitaxel (taxol) has a superior outcome in terms of response rates and progression-free survival. Howeve...
  3. Aryl hydrocarbon receptor is necessary to protect fetal human pulmonary microvascular endothelial cells against hyperoxic injury: Mechanistic roles of antioxidant enzymes and RelB.

    Toxicology and Applied Pharmacology 286(2):92 (2015) PMID 25831079 PMCID PMC4458211

    Hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD) in premature infants. Activation of the aryl hydrocarbon receptor (AhR) protects adult and newborn mice against hyperoxic lung injury by mediating increases in the expression of phase I (cytochrome P450 (CYP) 1A) and ph...
  4. Polycyclic aromatic hydrocarbons: from metabolism to lung cancer.

    Toxicological Sciences 145(1):5 (2015) PMID 25911656 PMCID PMC4408964

    Excessive exposure to polycyclic aromatic hydrocarbons (PAHs) often results in lung cancer, a disease with the highest cancer mortality in the United States. After entry into the lung, PAHs induce phase I metabolic enzymes such as cytochrome P450 (CYP) monooxygenases, i.e. CYP1A1/2 and 1B1, and ...
  5. Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro.

    Biochemical and Biophysical Research Communicat... 450(4):1345 (2014) PMID 24997337 PMCID PMC4216694

    Caffeine is used to prevent bronchopulmonary dysplasia (BPD) in premature neonates. Hyperoxia contributes to the development of BPD, inhibits cell proliferation and decreases cell survival. The mechanisms responsible for the protective effect of caffeine in pulmonary oxygen toxicity remain large...
  6. Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo by inducible RNA interference.

    PLoS ONE 9(7):e101263 (2014) PMID 24988319 PMCID PMC4079684

    Prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase 2 (COX-2), plays a critical role in many normal physiological functions and modulates a variety of pathological conditions. The ability to turn endogenous COX-2 on and off in a reversible fashion, at specific times and i...
  7. Three-dimensional reconstruction of thoracic structures: based on Chinese Visible Human.

    Computational and Mathematical Methods in Medicine 2013:795650 (2013) PMID 24369489 PMCID PMC3857995

    We managed to establish three-dimensional digitized visible model of human thoracic structures and to provide morphological data for imaging diagnosis and thoracic and cardiovascular surgery. With Photoshop software, the contour line of lungs and mediastinal structures including heart, aorta and...
  8. A voxel-map quantitative analysis approach for atherosclerotic noncalcified plaques of the coronary artery tree.

    Computational and Mathematical Methods in Medicine 2013:957195 (2013) PMID 24348749 PMCID PMC3855949

    Noncalcified plaques (NCPs) are associated with the presence of lipid-core plaques that are prone to rupture. Thus, it is important to detect and monitor the development of NCPs. Contrast-enhanced coronary Computed Tomography Angiography (CTA) is a potential imaging technique to identify atheros...
  9. In vivo imaging of brain infarct with the novel fluorescent probe PSVue 794 in a rat middle cerebral artery occlusion-reperfusion model.

    Molecular Imaging 12(1):8 (2013) PMID 23348787

    The utility of PSVue 794 (PS794), a near-infrared fluorescent dye conjugated to a bis[zinc (II)-dipicolylamine] (Zn-DPA) targeting moiety, in imaging brain infarct was assessed in a rat middle cerebral artery occlusion-reperfusion model. Following reperfusion, 1 mM PS794 solution was administere...
  10. Diurnal variation of ocular exposure to solar ultraviolet radiation based on data from a manikin head.

    Photochemistry and Photobiology 88(3):736 (2012) PMID 22268421

    Measurements were conducted at San Ya, China (18.4°N, 109.7°E, altitude 18 m) to investigate the diurnal variation of ocular exposure to ultraviolet (UV) radiation. The experimental apparatus was composed of a manikin and a dual-detector spectrometer to simultaneously measure ocular and ambient ...
  11. Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptor.

    Free Radical Biology and Medicine 51(10):1910 (2011) PMID 21906671 PMCID PMC3901644

    Hyperoxia contributes to the development of bronchopulmonary dysplasia in premature infants. Earlier we observed that aryl hydrocarbon receptor (AhR)-deficient mice are more susceptible to hyperoxic lung injury than AhR-sufficient mice, and this phenomenon was associated with a lack of expressio...
  12. Structure of the guanylyltransferase domain of human mRNA capping enzyme.

    PNAS 108(25):10104 (2011) PMID 21636784 PMCID PMC3121809

    The enzyme guanylyltransferase (GTase) plays a central role in the three-step catalytic process of adding an (m7)GpppN cap cotranscriptionally to nascent mRNA (pre-mRNAs). The 5'-mRNA capping process is functionally and evolutionarily conserved from unicellular organisms to human. However, the G...
  13. Delayed postoperative hemorrhage in 21 patients with intracranial epidermoid cysts.

    Journal of Neurosurgery 114(6):1592 (2011) PMID 21275558

    Intracranial epidermoid cysts are rare, potentially curable, benign lesions that are sometimes associated with severe postoperative complications, including hemorrhage. Delayed hemorrhage, defined as one that occurred after an initial unremarkable postoperative CT scan, contributed to most cases...
  14. Ground-based Observations of Ultraviolet and Total Solar Radiation in Shenyang, Northeast China

    Biomedical and Environmental Sciences 24(5):499 (2011) PMID 22108415

    Objective This work explores the diurnal variation of Solar ultraviolet radiation (UVR) and total solar radiation (TSR) in northeast China, using daily observations of UVR and TSR in Shenyang.
  15. Ground-based Observations of Ultraviolet and Total Solar Radiation in Shenyang, Northeast China

    Biomedical and Environmental Sciences 24(5):499 (2011) PMID 22108415

    Objective This work explores the diurnal variation of Solar ultraviolet radiation (UVR) and total solar radiation (TSR) in northeast China, using daily observations of UVR and TSR in Shenyang.
  16. Multiresidue method for high-performance liquid chromatography determination of carbamate pesticides residues in tea samples.

    Journal of Environmental Science and Health, Pa... 44(1):58 (2009) PMID 19089716

    A multiresidue method was developed to determine 19 carbamate pesticides in tea samples. Optimizations of different parameters, such as the type of extraction solvents, clean-up cartridges, and elution solvents were carried out. The developed method used acetonitrile as extraction solvent, amino...
  17. Apoptosis and autophagy induction in mammalian cells by small interfering RNA knockdown of mRNA capping enzymes.

    Molecular and Cellular Biology 28(19):5829 (2008) PMID 18678651 PMCID PMC2547012

    Addition of a 5' cap to RNA polymerase II transcripts, the first step of pre-mRNA processing in eukaryotes from yeasts to mammals, is catalyzed by the sequential action of RNA triphosphatase, guanylyltransferase, and (guanine-N-7)methyltransferase. The effects of knockdown of these capping enzym...
  18. Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter.

    Journal of Gene Medicine 10(3):306 (2008) PMID 18085726

    Rats with experimental Parkinson's disease (PD) are treated with intravenous glial-derived neurotrophic factor (GDNF) plasmid DNA, non-viral gene therapy using Trojan horse liposomes (THLs) targeted with a monoclonal antibody (MAb) to the rat transferrin receptor (TfR). Expression of the transge...
  19. Blood-brain barrier genomics and cloning of a novel organic anion transporter.

    Journal of Cerebral Blood Flow and Metabolism 28(2):291 (2008) PMID 17667996 PMCID PMC2892270

    A novel organic anion transporter selectively expressed at the blood-brain barrier (BBB), originally designated BBB-specific anion transporter type 1 (BSAT1), and now classified as Slco1c1, has been cloned from a BBB genomics program as a partial cDNA; this study describes the cloning and expres...
  20. Human capping enzyme promotes formation of transcriptional R loops in vitro.

    PNAS 104(45):17620 (2007) PMID 17978174 PMCID PMC2077024

    Cap formation is the first step of pre-mRNA processing in eukaryotic cells. Immediately after transcription initiation, capping enzyme (CE) is recruited to RNA polymerase II (Pol II) by the phosphorylated carboxyl-terminal domain of the Pol II largest subunit (CTD), allowing cotranscriptional ca...