1. Adipose VEGF Links the White-to-Brown Fat Switch With Environmental, Genetic, and Pharmacological Stimuli in Male Mice.

    Endocrinology 156(6):2059 (2015) PMID 25763639 PMCID PMC4430610

    Living in an enriched environment (EE) decreases adiposity, increases energy expenditure, causes resistance to diet induced obesity, and induces brown-like (beige) cells in white fat via activating a hypothalamic-adipocyte axis. Here we report that EE stimulated vascular endothelial growth facto...
  2. Gene Expression Analyses Identify Narp Contribution in the Development of l-DOPA-Induced Dyskinesia.

    Journal of Neuroscience 35(1):96 (2015) PMID 25568106

    In Parkinson's disease, long-term dopamine replacement therapy is complicated by the appearance of l-DOPA-induced dyskinesia (LID). One major hypothesis is that LID results from an aberrant transcriptional program in striatal neurons induced by l-DOPA and triggered by the activation of ERK. To i...
  3. Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia.

    Journal of Neuroscience 35(1):96 (2015) PMID 25568106

    In Parkinson's disease, long-term dopamine replacement therapy is complicated by the appearance of L-DOPA-induced dyskinesia (LID). One major hypothesis is that LID results from an aberrant transcriptional program in striatal neurons induced by L-DOPA and triggered by the activation of ERK. To i...
  4. Gene Expression Analyses Identify Narp Contribution in the Development of l-DOPA-Induced Dyskinesia.

    Journal of Neuroscience 35(1):96 (2015) PMID 25568106

    In Parkinson's disease, long-term dopamine replacement therapy is complicated by the appearance of l-DOPA-induced dyskinesia (LID). One major hypothesis is that LID results from an aberrant transcriptional program in striatal neurons induced by l-DOPA and triggered by the activation of ERK. To i...
  5. Neuronal activity-regulated pentraxin expressed in medial prefrontal cortex neurons is not necessary for extinction of heroin self-administration.

    Behavioural Pharmacology 24(4):332 (2013) PMID 23751516 PMCID PMC3779366

    The medial prefrontal cortex (mPFC) plays a key role in extinction learning. Previously, we found that expression of a neuronal activity-regulated pentraxin (Narp) dominant-negative construct in the mPFC of mice blocked extinction of morphine-conditioned place preference. To further investigate ...
  6. Neuronal activity-regulated pentraxin expressed in medial prefrontal cortex neurons is not necessary for extinction of heroin self-administration.

    Behavioural Pharmacology 24(4):332 (2013) PMID 23751516 PMCID PMC3779366

    The medial prefrontal cortex (mPFC) plays a key role in extinction learning. Previously, we found that expression of a neuronal activity-regulated pentraxin (Narp) dominant-negative construct in the mPFC of mice blocked extinction of morphine-conditioned place preference. To further investigate ...
  7. Fat grafting as a vehicle for the delivery of recombinant adenoassociated viral vectors to achieve gene modification of muscle flaps.

    Annals of Plastic Surgery 70(6):726 (2013) PMID 23403543 PMCID PMC3777653

    The combination of gene therapy and plastic surgery may have the potential to improve the specificity that is needed to achieve clinically applicable treatment regimens. Our goal was to develop a method for gene modification that would yield sustainable production of gene products but would be l...
  8. Fat grafting as a vehicle for the delivery of recombinant adenoassociated viral vectors to achieve gene modification of muscle flaps.

    Annals of Plastic Surgery 70(6):726 (2013) PMID 23403543 PMCID PMC3777653

    The combination of gene therapy and plastic surgery may have the potential to improve the specificity that is needed to achieve clinically applicable treatment regimens. Our goal was to develop a method for gene modification that would yield sustainable production of gene products but would be l...
  9. Fat grafting as a vehicle for the delivery of recombinant adenoassociated viral vectors to achieve gene modification of muscle flaps.

    Annals of Plastic Surgery 70(6):726 (2013) PMID 23403543 PMCID PMC3777653

    The combination of gene therapy and plastic surgery may have the potential to improve the specificity that is needed to achieve clinically applicable treatment regimens. Our goal was to develop a method for gene modification that would yield sustainable production of gene products but would be l...
  10. Role of medial prefrontal cortex Narp in the extinction of morphine conditioned place preference.

    Learning & Memory 20(2):75 (2013) PMID 23322555 PMCID PMC3549059

    Narp knockout (KO) mice demonstrate an impaired extinction of morphine conditioned place preference (CPP). Because the medial prefrontal cortex (mPFC) has been implicated in extinction learning, we tested whether Narp cells in this region play a role in the extinction of morphine CPP. We found t...
  11. Role of medial prefrontal cortex Narp in the extinction of morphine conditioned place preference.

    Learning & Memory 20(2):75 (2013) PMID 23322555 PMCID PMC3549059

    Narp knockout (KO) mice demonstrate an impaired extinction of morphine conditioned place preference (CPP). Because the medial prefrontal cortex (mPFC) has been implicated in extinction learning, we tested whether Narp cells in this region play a role in the extinction of morphine CPP. We found t...
  12. Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy.

    Neuron 75(2):283 (2012) PMID 22841313 PMCID PMC3408581

    Mice lacking the vesicular glutamate transporter-3 (VGLUT3) are congenitally deaf due to loss of glutamate release at the inner hair cell afferent synapse. Cochlear delivery of VGLUT3 using adeno-associated virus type 1 (AAV1) leads to transgene expression in only inner hair cells (IHCs), despit...
  13. Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy

    Neuron 75(2):283 (2012)

    Mice lacking the vesicular glutamate transporter-3 (VGLUT3) are congenitally deaf due to loss of glutamate release at the inner hair cell afferent synapse. Cochlear delivery of VGLUT3 using adeno-associated virus type 1 (AAV1) leads to transgene expression in only inner hair cells (IHC...
  14. Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy

    Neuron 75(2):283 (2012) PMID 22841313 PMCID PMC3408581

    Mice lacking the vesicular glutamate transporter-3 (VGLUT3) are congenitally deaf due to loss of glutamate release at the inner hair cell afferent synapse. Cochlear delivery of VGLUT3 using adeno-associated virus type 1 (AAV1) leads to transgene expression in only inner hair cells (IHC...
  15. Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy

    Neuron 75(2):283 (2012) PMID 22841313 PMCID PMC3408581

    Mice lacking the vesicular glutamate transporter-3 (VGLUT3) are congenitally deaf due to loss of glutamate release at the inner hair cell afferent synapse. Cochlear delivery of VGLUT3 using adeno-associated virus type 1 (AAV1) leads to transgene expression in only inner hair cells (IHC...
  16. Specific knockdown of the D2 long dopamine receptor variant.

    Neuroreport 23(1):1 (2012) PMID 22082989 PMCID PMC3227782

    Dopamine signaling in the nucleus accumbens is critical in mediating the effects of cocaine. There are two splice variants of dopamine D2 receptors, D2L and D2S, which are believed to have different functional roles. Here, we show, that knocking down D2L selectively using viral-mediated short-ha...
  17. Specific knockdown of the D2 long dopamine receptor variant.

    Neuroreport 23(1):1 (2012) PMID 22082989 PMCID PMC3227782

    Dopamine signaling in the nucleus accumbens is critical in mediating the effects of cocaine. There are two splice variants of dopamine D2 receptors, D2L and D2S, which are believed to have different functional roles. Here, we show, that knocking down D2L selectively using viral-mediated short-ha...
  18. White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis

    Cell Metabolism 14(3):324 (2011)

    Living in an enriched environment with complex physical and social stimulation leads to improved cognitive and metabolic health. In white fat, enrichment induced the upregulation of the brown fat cell fate determining gene Prdm16, brown fat-specific markers, and genes involved in therm...
  19. White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis.

    Cell Metabolism 14(3):324 (2011) PMID 21907139 PMCID PMC3172615

    Living in an enriched environment with complex physical and social stimulation leads to improved cognitive and metabolic health. In white fat, enrichment induced the upregulation of the brown fat cell fate determining gene Prdm16, brown fat-specific markers, and genes involved in thermogenesis a...
  20. White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis.

    Cell Metabolism 14(3):324 (2011) PMID 21907139 PMCID PMC3172615

    Living in an enriched environment with complex physical and social stimulation leads to improved cognitive and metabolic health. In white fat, enrichment induced the upregulation of the brown fat cell fate determining gene Prdm16, brown fat-specific markers, and genes involved in thermogenesis a...