1. Spastin binds to lipid droplets and affects lipid metabolism.

    PLoS Genetics 11(4):e1005149 (2015) PMID 25875445 PMCID PMC4395272

    Mutations in SPAST, encoding spastin, are the most common cause of autosomal dominant hereditary spastic paraplegia (HSP). HSP is characterized by weakness and spasticity of the lower limbs, owing to progressive retrograde degeneration of the long corticospinal axons. Spastin is a conserved micr...
  2. Spastin binds to lipid droplets and affects lipid metabolism.

    PLoS Genetics 11(4):e1005149 (2015) PMID 25875445 PMCID PMC4395272

    Mutations in SPAST, encoding spastin, are the most common cause of autosomal dominant hereditary spastic paraplegia (HSP). HSP is characterized by weakness and spasticity of the lower limbs, owing to progressive retrograde degeneration of the long corticospinal axons. Spastin is a conserved micr...
  3. Long-term live cell microscopy studies of lipid droplet fusion dynamics in adipocytes.

    Journal of Lipid Research 54(12):3419 (2013) PMID 24103784 PMCID PMC3826688

    During the adipogenic differentiation process of mesenchymal stem cells, lipid droplets (LDs) grow slowly by transferring lipids between each other. Recent findings hint at the possibility that a fusion pore is involved. In this study, we analyze lipid transfer data obtained in long-term label-f...
  4. Two-color glycan labeling of live cells by a combination of Diels-Alder and click chemistry.

    Angewandte Chemie. International edition in Eng... 52(15):4265 (2013) PMID 23468318

  5. Remodeling of lipid droplets during lipolysis and growth in adipocytes.

    Journal of Biological Chemistry 287(14):11164 (2012) PMID 22311986

    Synthesis, storage, and turnover of triacylglycerols (TAGs) in adipocytes are critical cellular processes to maintain lipid and energy homeostasis in mammals. TAGs are stored in metabolically highly dynamic lipid droplets (LDs), which are believed to undergo fragmentation and fusion under lipoly...
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  6. Fluorescent conjugated block copolymer nanoparticles by controlled mixing.

    Chemical Communications 48(15):2104 (2012) PMID 22246316

    Monitoring of the formation of stable fluorescent nanoparticles from controlled mixing of a THF solution of poly(fluorene ethynylene)-block-poly(ethylene glycol) in a microfluidic laminar flow crossjunction by spatially resolved fluorescence spectroscopy reveals the time scale of particle format...
  7. Fast and long term lipid droplet tracking with CARS microscopy.

    Journal of Biophotonics 4(6):435 (2011) PMID 21445955

    Photobleaching of organic fluorophores commonly used in fluorescence microscopy puts a limit to the number of images which can be acquired. Label-free imaging techniques therefore offer advantages both for rapid image acquisition and for long-term observations. CARS microscopy is a label-free im...
  8. Asymmetric PPCys: strongly fluorescing NIR labels.

    Chemical Communications 46(29):5289 (2010) PMID 20539898

    By a stepwise synthesis strategy biofunctionalized Pyrrolopyrrole Cyanines (PPCy) with an asymmetric substitution pattern were obtained. These exhibit extremely strong and narrowband NIR absorption and fluorescence. Internalization of a peptide bound PPCy is demonstrated using live cell microsco...