1. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364 PMCID PMC4344913

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  2. A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate

    Cell 160(5):1013 (2015)

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases ...
  3. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

    Cell 160(5):1013 (2015) PMID 25684364

    Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models have relatively long lifespans. Here, we develop the first platform for rapid exploration of age-dependent traits and diseases in vertebr...
  4. Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis.

    Molecular Biology of the Cell 23(14):2702 (2012) PMID 22621898 PMCID PMC3395659

    To achieve mitosis and cytokinesis, microtubules must assemble into distinct structures at different stages of cell division-mitotic spindles to segregate the chromosomes before anaphase and midzones to keep sister genomes apart and guide the cleavage furrow after anaphase. This temporal regulat...
  5. Midbody assembly and its regulation during cytokinesis.

    Molecular Biology of the Cell 23(6):1024 (2012) PMID 22278743 PMCID PMC3302730

    The midbody is a transient structure that connects two daughter cells at the end of cytokinesis, with the principal function being to localize the site of abscission, which physically separates two daughter cells. Despite its importance, understanding of midbody assembly and its regulation is st...
  6. KIF4 regulates midzone length during cytokinesis.

    Current Biology 21(10):815 (2011) PMID 21565503 PMCID PMC3100440

    Midzones, also called central spindles, are an array of antiparallel microtubules that form during cytokinesis between the separated chromosomes. Midzones can be considered to be platforms that recruit specific proteins and orchestrate cytokinetic events, such as sister nuclei being kept apart, ...
  7. KIF4 Regulates Midzone Length during Cytokinesis

    Current Biology 21(10):815 (2011)

    Background Midzones, also called central spindles, are an array of antiparallel microtubules that form during cytokinesis between the separated chromosomes. Midzones can be considered to be platforms that recruit specific proteins and orchestrate cytokinetic events, such as sister nucl...
  8. Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.

    Journal of Cell Biology 189(7):1097 (2010) PMID 20566684 PMCID PMC2894451

    Mitotic spindles play essential roles in chromosome congression and segregation during mitosis. Aurora A regulates spindle assembly in part via phosphorylating human TACC3 on S558, which triggers TACC3 relocalization to mitotic spindles and stabilizes microtubules (MTs). In this study, we identi...
  9. Cell polarization during monopolar cytokinesis.

    Journal of Cell Biology 181(2):195 (2008) PMID 18411311 PMCID PMC2315668

    During cytokinesis, a specialized set of proteins is recruited to the equatorial region between spindle poles by microtubules and actin filaments, enabling furrow assembly and ingression before cell division. We investigate the mechanisms underlying regional specialization of the cytoskeleton in...
  10. Reassembly of contractile actin cortex in cell blebs.

    Journal of Cell Biology 175(3):477 (2006) PMID 17088428 PMCID PMC2064524

    Contractile actin cortex is involved in cell morphogenesis, movement, and cytokinesis, but its organization and assembly are poorly understood. During blebbing, the membrane detaches from the cortex and inflates. As expansion ceases, contractile cortex re-assembles under the membrane and drives ...