1. Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes.

    Nature Medicine 13(11):1375 (2007) PMID 17952092

    Atopic allergy is characterized by an increase in IgE antibodies that signal through the high-affinity Fcepsilon receptor (FcepsilonRI) to induce the release of inflammatory mediators from mast cells. For unknown reasons, the prevalence of allergic diseases has recently increased steeply in the ...
  2. Effects of smoking cessation on lung function and airway inflammation in smokers with asthma.

    American Journal of Respiratory and Critical Ca... 174(2):127 (2006) PMID 16645173

    Active smoking in asthma is associated with worsening of symptoms, accelerated decline in lung function, and impaired response to corticosteroids. To examine the short-term effects of smoking cessation on lung function, airway inflammation, and corticosteroid responsiveness in smokers with asthm...
  3. Nerve growth factor in serum and lymphocyte culture in pigeon fanciers' acute hypersensitivity pneumonitis.

    Chest 130(1):37 (2006) PMID 16840380

    Nerve growth factor (NGF) is a neurotrophic cytokine with immunomodulatory activity. NGF contributes to neurogenic inflammation and has been described in asthma and idiopathic pulmonary fibrosis. To identify and quantify NGF in serum and peripheral blood lymphocyte cultures from pigeon fanciers,...
  4. Induction of protective and mucosal immunity against diphtheria by a immune stimulating complex (ISCOMS) based vaccine.

    Vaccine 24(24):5201 (2006) PMID 16650917

    There is increasing concern over the efficacy of existing vaccines for diphtheria and there is interest in the development of a mucosally active formulation which might improve local protection. Lipophilic immune stimulating complexes (ISCOMS) containing Quil A are active by both parenteral and ...
  5. Short and long-term effects of cigarette smoking independently influence exhaled nitric oxide concentration in asthma.

    Journal of Allergy and Clinical Immunology 116(1):88 (2005) PMID 15990779

    The fractional concentration of nitric oxide in exhaled breath (FeNO) is elevated in asthma. FeNO measurement has been proposed as a noninvasive index of disease activity. Cigarette smoking suppresses FeNO, which limits its use in smokers. To identify and model short-term and long-term influence...
  6. Effect of inhaled corticosteroids on symptom severity and sputum mediator levels in chronic persistent cough.

    Journal of Allergy and Clinical Immunology 113(6):1063 (2004) PMID 15208586

    Chronic cough often lasts for more than 1 year and is associated with airway inflammation. The effect of inhaled corticosteroids on symptom severity and inflammatory mediator levels in these patients is unknown. We sought to determine whether inhaled corticosteroids reduce cough severity and spu...