1. The role of the commensal microbiota in the regulation of tolerance to dietary allergens.

    Current Opinion in Allergy and Clinical Immunology 15(3):243 (2015) PMID 25827065 PMCID PMC4498960

    We review the evidence that environmental stimuli that perturb naturally selected host-microbe interactions are driving the increasing prevalence of food allergy and examine the mechanisms by which commensal bacteria regulate tolerance to dietary allergens. Antibiotic use and the consumption of ...
  2. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.

    Cell 161(2):264 (2015) PMID 25860609 PMCID PMC4393509

    The gastrointestinal (GI) tract contains much of the body's serotonin (5-hydroxytryptamine, 5-HT), but mechanisms controlling the metabolism of gut-derived 5-HT remain unclear. Here, we demonstrate that the microbiota plays a critical role in regulating host 5-HT. Indigenous spore-forming bacter...
  3. Our interface with the built environment: immunity and the indoor microbiota

    Trends in Immunology 36(3):121 (2015) PMID 25754179

    The rise of urbanization and an increasingly indoor lifestyle has affected human interactions with our microbiota in unprecedented ways. We discuss how this lifestyle may influence immune development and function, and argue that it is time that we examined ways to manipulate the indoor...
  4. Cellular and molecular pathways through which commensal bacteria modulate sensitization to dietary antigens

    Current Opinion in Immunology 31:79 (2014)

    • The commensal microbiota regulates sensitization to food antigens. • Many cell types interact with commensal bacteria including IEC, DC, and ILC. ...
  5. Cellular and molecular pathways through which commensal bacteria modulate sensitization to dietary antigens.

    Current Opinion in Immunology 31:79 (2014) PMID 25458998 PMCID PMC4255329

    Food allergies are a growing public health concern. The rapidly increasing prevalence of allergic disease cannot be explained by genetic variation alone, suggesting a role for gene-by-environment interactions. The bacteria that colonize barrier surfaces, often referred to as the commensal microb...
  6. Cellular and molecular pathways through which commensal bacteria modulate sensitization to dietary antigens.

    Current Opinion in Immunology 31:79 (2014) PMID 25458998 PMCID PMC4255329

    Food allergies are a growing public health concern. The rapidly increasing prevalence of allergic disease cannot be explained by genetic variation alone, suggesting a role for gene-by-environment interactions. The bacteria that colonize barrier surfaces, often referred to as the commensal microb...
  7. Cellular and molecular pathways through which commensal bacteria modulate sensitization to dietary antigens.

    Current Opinion in Immunology 31:79 (2014) PMID 25458998

    Food allergies are a growing public health concern. The rapidly increasing prevalence of allergic disease cannot be explained by genetic variation alone, suggesting a role for gene-by-environment interactions. The bacteria that colonize barrier surfaces, often referred to as the commensal microb...
  8. The role of commensal bacteria in the regulation of sensitization to food allergens.

    FEBS Letters 588(22):4258 (2014) PMID 24791655 PMCID PMC4216641

    The prevalence of life-threatening anaphylactic responses to food is rising at an alarming rate. The emerging role of the gut microbiota in regulating food allergen sensitization may help explain this trend. The mechanisms by which commensal bacteria influence sensitization to dietary antigens a...
  9. The role of commensal bacteria in the regulation of sensitization to food allergens.

    FEBS Letters 588(22):4258 (2014) PMID 24791655

    The prevalence of life-threatening anaphylactic responses to food is rising at an alarming rate. The emerging role of the gut microbiota in regulating food allergen sensitization may help explain this trend. The mechanisms by which commensal bacteria influence sensitization to dietary antigens a...
  10. The role of commensal bacteria in the regulation of sensitization to food allergens.

    FEBS Letters 588(22):4258 (2014) PMID 24791655 PMCID PMC4216641

    The prevalence of life-threatening anaphylactic responses to food is rising at an alarming rate. The emerging role of the gut microbiota in regulating food allergen sensitization may help explain this trend. The mechanisms by which commensal bacteria influence sensitization to dietary antigens a...
  11. The role of commensal bacteria in the regulation of sensitization to food allergens.

    FEBS Letters 588(22):4258 (2014) PMID 24791655 PMCID PMC4216641

    The prevalence of life-threatening anaphylactic responses to food is rising at an alarming rate. The emerging role of the gut microbiota in regulating food allergen sensitization may help explain this trend. The mechanisms by which commensal bacteria influence sensitization to dietary antigens a...
  12. TLR4 regulates IFN-γ and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation.

    Journal of Leukocyte Biology 96(5):895 (2014) PMID 25015957 PMCID PMC4197555

    Tregs play a crucial role in the maintenance of intestinal immune homeostasis. However, significant numbers of Foxp3(+) Tregs accumulate in the inflamed lesions in experimental colitis and in IBD patients. Treg production of the proinflammatory cytokines IFN-γ and/or IL-17 may arguably explain t...
  13. TLR4 regulates IFN-γ and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation.

    Journal of Leukocyte Biology 96(5):895 (2014) PMID 25015957 PMCID PMC4197555

    Tregs play a crucial role in the maintenance of intestinal immune homeostasis. However, significant numbers of Foxp3(+) Tregs accumulate in the inflamed lesions in experimental colitis and in IBD patients. Treg production of the proinflammatory cytokines IFN-γ and/or IL-17 may arguably explain t...
  14. TLR4 regulates IFN-γ and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation.

    Journal of Leukocyte Biology 96(5):895 (2014) PMID 25015957 PMCID PMC4197555

    Tregs play a crucial role in the maintenance of intestinal immune homeostasis. However, significant numbers of Foxp3(+) Tregs accumulate in the inflamed lesions in experimental colitis and in IBD patients. Treg production of the proinflammatory cytokines IFN-γ and/or IL-17 may arguably explain t...
  15. TLR4 regulates IFN-γ and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation.

    Journal of Leukocyte Biology 96(5):895 (2014) PMID 25015957 PMCID PMC4197555

    Tregs play a crucial role in the maintenance of intestinal immune homeostasis. However, significant numbers of Foxp3(+) Tregs accumulate in the inflamed lesions in experimental colitis and in IBD patients. Treg production of the proinflammatory cytokines IFN-γ and/or IL-17 may arguably explain t...
  16. Health: The weighty costs of non-caloric sweeteners.

    Nature 514(7521):176 (2014) PMID 25231865 PMCID PMC4449731

  17. Health: The weighty costs of non-caloric sweeteners.

    Nature 514(7521):176 (2014) PMID 25231865

  18. Health: The weighty costs of non-caloric sweeteners.

    Nature 514(7521):176 (2014) PMID 25231865

  19. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis

    Cell (2014)

    The gastrointestinal (GI) tract contains much of the body’s serotonin (5-hydroxytryptamine, 5-HT), but mechanisms controlling the metabolism of gut-derived 5-HT remain unclear. Here we demonstrate that the microbiota plays a critical role in regulating host 5-HT. Indigenous spore-formi...
  20. Commensal bacteria protect against food allergen sensitization.

    PNAS 111(36):13145 (2014) PMID 25157157 PMCID PMC4246970

    Environmentally induced alterations in the commensal microbiota have been implicated in the increasing prevalence of food allergy. We show here that sensitization to a food allergen is increased in mice that have been treated with antibiotics or are devoid of a commensal microbiota. By selective...