1. Improving Developmental Screening in a Resident Group Continuity Clinic Practice

    Academic Pediatrics 11(4):e10 (2011)

  2. Long-term functional results for the surgical management of neurogenic thoracic outlet syndrome.

    Vascular and Endovascular Surgery 44(7):550 (2010) PMID 20675314

    To document long-term functional outcomes in patients treated for neurogenic thoracic outlet syndrome (NTOS). Records of all patients undergoing treatment for NTOS at our center were reviewed. Patient demographics and co-morbidities were recorded. End-points included symptomatic relief, peri-ope...
  3. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in Alzheimer mice

    Alzheimer's & Dementia 6(4):S535 (2010)

  4. Pulmonary embolism outcome: a prospective evaluation of CT pulmonary angiographic clot burden score and ECG score.

    American Journal of Roentgenology 190(6):1599 (2008) PMID 18492912

    The purpose of this study was to establish whether a correlation exists between the CT pulmonary angiographic clot burden score, the ECG score at diagnosis, and the 12-month mortality rate among patients diagnosed with pulmonary embolism. A total of 523 consecutive patients who underwent CT pulm...
  5. Branched stent-grafts: will these become the new standard?

    Journal of Vascular and Interventional Radiology 19(6 Suppl):S57 (2008) PMID 18502388

    During the past 15 years, endovascular methods of repair have assumed an ever more prominent role in the management of aortic aneurysms because they do not require direct exposure of the aneurysm and do not interrupt flow through the aneurysm. However, one cannot use endovascular techniques to e...
  6. Ezetimibe blocks internalization of the NPC1L1/cholesterol complex.

    Cell Metabolism 7(6):469 (2008) PMID 18522826

    Niemann-Pick C1-like 1 (NPC1L1) is a target for ezetimibe, a drug that blocks intestinal cholesterol absorption. A new study by Ge et al. (2008) in this issue of Cell Metabolism shows that non-lipoprotein-bound cholesterol induces endocytosis of NPC1L1 and that ezetimibe blocks the internalizati...
  7. Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation

    Bioorganic & Medicinal Chemistry Letters 18(14):3925 (2008) PMID 18579373

    Inhibition of the PHD2 enzyme has been associated with increased red blood cell levels. From a screening hit, a series of novel hydroxyl-thiazoles were developed as potent PHD2 inhibitors.
  8. Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation

    Bioorganic & Medicinal Chemistry Letters 18(14):3925 (2008) PMID 18579373

    Inhibition of the PHD2 enzyme has been associated with increased red blood cell levels. From a screening hit, a series of novel hydroxyl-thiazoles were developed as potent PHD2 inhibitors.
  9. Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation

    Bioorganic & Medicinal Chemistry Letters 18(14):3925 (2008) PMID 18579373

    Inhibition of the PHD2 enzyme has been associated with increased red blood cell levels. From a screening hit, a series of novel hydroxyl-thiazoles were developed as potent PHD2 inhibitors.
  10. New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation.

    Bioorganic & Medicinal Chemistry Letters 17(23):6633 (2007) PMID 17920884

    We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro.
  11. Gefitinib inhibition of drug resistance to doxorubicin by inactivating ABCG2 in thyroid cancer cell lines.

    Archives of Otolaryngology - Head & Neck Surgery 133(10):1022 (2007) PMID 17938326

    To investigate the regulation of the breast cancer resistance protein ABCG2/BRCP1 drug transporter by epidermal growth factor receptor (EGFR) kinase activity, and to determine whether gefitinib, an EGFR small molecule inhibitor, will modulate the effects of doxorubicin hydrochloride by inhibitin...
  12. Temporal dynamics of basal ganglia response and connectivity during verbal working memory

    NeuroImage 34(3):1253 (2007)

    Research on the neural basis of working memory (WM) has generally focused on neocortical regions; comparatively little is known about the role of subcortical structures. There is growing evidence that the basal ganglia are involved in WM, but their contribution to different component p...
  13. Temporal dynamics of basal ganglia response and connectivity during verbal working memory.

    NeuroImage 34(3):1253 (2007) PMID 17175179

    Research on the neural basis of working memory (WM) has generally focused on neocortical regions; comparatively little is known about the role of subcortical structures. There is growing evidence that the basal ganglia are involved in WM, but their contribution to different component processes o...
  14. New ‘chemical probes’ to examine the role of the hFPRL1 (or ALXR) receptor in inflammation

    Bioorganic & Medicinal Chemistry Letters 17(23):6633 (2007)

    We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro. ...
  15. Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis.

    Acta Biochimica et Biophysica Sinica 38(3):151 (2006) PMID 16518538

    Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A. At the single-cell level, ACAT serves as a regulator of intracellular cholesterol homeostasis. In addition, ACAT supplies cholesteryl esters for lipopr...
  16. Tracking the direct alloimmune response in vivo with a new CD4+ T cell receptor transgenic mouse model

    Journal of the American College of Surgeons 199(3):94 (2004)

    Introduction: T cell receptor transgenic (TCR-tg) mice have been critical to the study of T cell responses in vivo. The alloimmune CD8+ TCR-tg, 2C, has revealed important insights into the responses of the CD8+ T cell in transplant rejection. We thus developed a CD4+ TCR-tg mouse wit...
  17. Dipyridamole-thallium/sestamibi before vascular surgery: A prospective blinded study in moderate-risk patients

    Journal of Vascular Surgery 32(1):77 (2000) PMID 10876209

    Purpose: This study assessed in a prospective, blinded fashion whether a reversible defect on dipyridamole-thallium (DTHAL)/sestamibi (DMIBI) can predict adverse cardiac events after elective vascular surgery in patients with one or more clinical risk factors. Methods: Consecutive pati...
  18. Brush cytology during ERCP for the diagnosis of biliary and pancreatic malignancies

    Gastrointestinal Endoscopy 40(2):140 (1994)

    Endoscopic retrograde cholangiopancreatography is a valuable tool in the diagnosis and management of pancreaticobiliary diseases. The diagnostic sensitivity of brush cytology is reported as between 18%and 70%for malignant bile duct or pancreatic duct strictures. We report our findings in 74...
  19. Polylysine binding to histone-bound regions in chromatin

    Biochemical and Biophysical Research Communicat... 47(4):883 (1972)

    Thermal denaturation of calf thymus nucleohistone, polylysine-nucleohistone and polylysine-pure DNA were studied. In calf thymus nucleohistone polylysine binds preferentially to the DNA regions originally bound by non-histone proteins or the gaps between adjacent histone-bound regions and r...