1. The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape

    Current Biology 25(21):2878 (2015)

  2. The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape.

    Current Biology 25(19):2518 (2015) PMID 26387712 PMCID PMC4714572

    Over the past few years, studies of DNA isolated from human fossils and archaeological remains have generated considerable novel insight into the history of our species. Several landmark papers have described the genomes of ancient humans across West Eurasia, demonstrating the presence of large-...
  3. Carboxypeptidase A6 gene (CPA6) mutations in a recessive familial form of febrile seizures and temporal lobe epilepsy and in sporadic temporal lobe epilepsy.

    Human Mutation 33(1):124 (2012) PMID 21922598

    Febrile seizures (FS) and temporal lobe epilepsy (TLE) were found in four of the seven siblings born to healthy Moroccan consanguineous parents. We hypothesized autosomal recessive (AR) inheritance. Combined linkage analysis and autozygosity mapping of a genome-wide single nucleotide polymorphis...
  4. BRD2 and TAP-1 genes and juvenile myoclonic epilepsy.

    Neurological Sciences 31(1):53 (2010) PMID 19953286

    Juvenile myoclonic epilepsy (JME) is a genetically determined common subtype of idiopathic generalized epilepsy. Linkage of JME to the chromosomal region 6p21.3 has been reported. An association has been previously observed between JME and the positional candidate, 6p21.3 linked, BRD2. Another c...
  5. Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence.

    Addictive Behaviors 34(9):772 (2009) PMID 19482438

    We assessed whether smoking behavior was associated with nine polymorphisms in genes coding for the nicotinic receptor subunits alpha-4 (rs1044394, rs1044396, rs2236196 and rs2273504), alpha-5 (rs16969968), beta-2 (rs2072661 and rs4845378) and beta-3 (rs4953 and rs6474413).We conducted an Intern...
  6. Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene.

    Bipolar Disorders 10(5):580 (2008) PMID 18657242

    Recent data suggest that brain-derived neurotrophic factor (BDNF) and the serotonergic system are involved and interact in major depressive disorder and suicidal behavior (SB). Several family and population-based studies have reported associations between the BDNF gene and serotonin-related gene...
  7. Catechol-O-methyltransferase polymorphism (COMT) in suicide attempters: a possible gender effect on anger traits.

    American Journal of Medical Genetics. Part B: N... 144B(8):1042 (2007) PMID 17510945

    Anger-related personality traits are considered contributory risk factors for suicidal behavior. According to twin studies, they are partially under genetic control and their various clinical expressions have been associated with serotonergic and catecholaminergic activities. A functional polymo...
  8. The influence of four serotonin-related genes on decision-making in suicide attempters.

    American Journal of Medical Genetics. Part B: N... 144B(5):615 (2007) PMID 17221847

    Genetic factors have been associated with the vulnerability to suicidal behavior. We previously reported decision-making impairment in suicide attempters and hypothesized that these cognitive alterations may represent an endophenotype of suicidal behavior. In this study, we aimed to investigate ...
  9. No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects.

    Biological Psychiatry 60(2):202 (2006) PMID 16581035

    It was recently reported that a rare functional variant, R441H, in the human tryptophan hydroxylase-2 gene (hTPH2) could represent an important risk factor for unipolar major depression (UP) since it was originally found in 10% of UP patients (vs. 1.4% in control subjects). We explored the occur...
  10. No Human Tryptophan Hydroxylase-2 Gene R441H Mutation in a Large Cohort of Psychiatric Patients and Control Subjects

    Biological Psychiatry 60(2):202 (2006)

    Background It was recently reported that a rare functional variant, R441H, in the human tryptophan hydroxylase-2 gene (hTPH2) could represent an important risk factor for unipolar major depression (UP) since it was originally found in 10% of UP patients (vs. 1.4% in control subjects). ...
  11. The monoamine oxidase A gene may influence the means used in suicide attempts.

    Psychiatric Genetics 15(3):189 (2005) PMID 16094253

    Compelling evidence suggests that serotonin system dysfunction is associated with certain behavioral disorders, including suicidal behavior and impulsive aggression. A functional polymorphism in the promoter region of the monoamine oxidase A gene (uVNTR) was recently identified and the presence ...
  12. GABA receptor 1 polymorphism (G1465A) and temporal lobe epilepsy.

    Epilepsia 46(6):931 (2005) PMID 15946333

    To reevaluate the genetic contribution of the polymorphism G1465A of the gene coding for gamma-aminobutyric acid (GABA)(B) receptor 1 subunit [GABA(B)(1)] in a sample of French patients with temporal lobe epilepsy (TLE) and to perform an exploratory analysis in other phenotypic subgroups. The 13...
  13. Suicidal behavior: relationship between phenotype and serotonergic genotype.

    American Journal of Medical Genetics. Part C: S... 133C(1):25 (2005) PMID 15645480

    The basis of suicidal behavior (SB) is complex and multifactorial. Numerous risk factors have been identified. Epidemiological genetics studies (family studies, twin studies, adoption studies) suggest that there is a genetic basis to SB and that this genetic basis is specific and independent fro...
  14. [Implication of genes of the serotonergic system on vulnerability to suicidal behavior].

    Journal of Psychiatry and Neuroscience 29(5):350 (2004) PMID 15534946

    There are many risk factors associated with vulnerability to suicidal behaviour, and the results of family studies, twin studies and adoption studies suggest that they include a genetic predisposition. Moreover, this gentic susceptibility may be specific and independent of the genetic susceptibi...
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  15. Lack of association between 5HT2A receptor gene haplotype, bipolar disorder and its clinical subtypes in a West European sample.

    American Journal of Medical Genetics. Part B: N... 129B(1):29 (2004) PMID 15274035

    Bipolar affective disorder (BPAD) is a complex psychiatric disorder with a major genetic contribution. Abnormalities in serotonergic function have been implicated in its aetiology. The 5HT2A receptor (5HT2AR) gene is a strong candidate gene for involvement in BPAD, but previous association studi...
  16. Serotonin transporter gene may be involved in short-term risk of subsequent suicide attempts.

    Biological Psychiatry 55(1):46 (2004) PMID 14706424

    In the first year following a suicide attempt, patients are at high risk for reattempt and for completed suicide. We aim to determine the predictive value of two serotonin-related genes, the tryptophan hydroxylase (TPH) and serotonin transporter (5-HTTLPR) genes that have been involved in the su...
  17. FOunder effect in patients with Unverricht-Lundborg disease on reunion island.

    Epilepsia 44(10):1357 (2003) PMID 14510831

    Unverricht-Lundborg disease (ULD) is the most frequent form of progressive myoclonus epilepsy. ULD is caused mostly by a homozygous expansion of a dodecamer repeat in the cystatin B gene (CSTB) promoter. We present here a clinical and molecular study of 14 ULD patients originating from Reunion I...
  18. No association between non-violent suicidal behavior and the serotonin transporter promoter polymorphism.

    American Journal of Medical Genetics. Part B: N... 116B(1):72 (2003) PMID 12497618

    There is compelling evidence that suicidal behavior is associated with the dysfunction of the serotonin system. A functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) was recently identified and the presence of the short allele was associated with lower gen...
  19. Haplotype study of West European and North African Unverricht-Lundborg chromosomes: evidence for a few founder mutations.

    Human Genetics 111(3):255 (2002) PMID 12215838

    Unverricht-Lundborg disease (ULD) is a progressive myoclonus epilepsy common in Finland and North Africa, and less common in Western Europe. ULD is mostly caused by expansion of a dodecamer repeat in the cystatin B gene ( CSTB) promoter. We performed a haplotype study of ULD chromosomes (ULDc) w...
  20. Identification of a New Locus for Generalized Epilepsy with Febrile Seizures Plus (GEFS+) on Chromosome 2q24-q33

    The American Journal of Human Genetics 65(5):1396 (1999)

    Summary We report the identification of a new locus for generalized epilepsy with febrile seizures plus (GEFS+). Six family members manifested isolated typical febrile seizures (FS), and five had typical FS associated with generalized epilepsy (FS+, generalized tonic/clonic seizures). ...