1. PER2 Differentially Regulates Clock Phosphorylation versus Transcription by Reciprocal Switching of CK1ε Activity.

    Journal of Biological Rhythms 30(3):206 (2015) PMID 25994100

    Casein kinase 1ε (CK1ε) performs key phosphorylation reactions in the circadian clock mechanism that determine period. We show that the central clock protein PERIOD2 (PER2) not only acts as a transcriptional repressor but also inhibits the autoinactivation of CK1ε, thereby promoting CK1ε activit...
  2. Ube3a imprinting impairs circadian robustness in angelman syndrome models.

    Current Biology 25(5):537 (2015) PMID 25660546 PMCID PMC4348236

    The paternal allele of Ube3a is silenced by imprinting in neurons, and Angelman syndrome (AS) is a disorder arising from a deletion or mutation of the maternal Ube3a allele, which thereby eliminates Ube3a neuronal expression. Sleep disorders such as short sleep duration and increased sleep onset...
  3. Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.

    Journal of Autism and Developmental Disorders 45(1):100 (2015) PMID 25059483 PMCID PMC4289108

    Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically uni...
  4. Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.

    Journal of Autism and Developmental Disorders 45(1):100 (2015) PMID 25059483

    Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically uni...
  5. Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.

    Journal of Autism and Developmental Disorders 45(1):100 (2015) PMID 25059483

    Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically uni...
  6. Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.

    Journal of Autism and Developmental Disorders 45(1):100 (2015) PMID 25059483 PMCID PMC4289108

    Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically uni...
  7. Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.

    Journal of Autism and Developmental Disorders 45(1):100 (2015) PMID 25059483 PMCID PMC4289108

    Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically uni...
  8. Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.

    Journal of Autism and Developmental Disorders 45(1):100 (2015) PMID 25059483

    Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically uni...
  9. Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.

    Journal of Autism and Developmental Disorders 45(1):100 (2015) PMID 25059483 PMCID PMC4289108

    Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically uni...
  10. Woody Hastings: 65 years of fun.

    PNAS 111(42):14964 (2014) PMID 25271327 PMCID PMC4210301

  11. Woody Hastings: 65 years of fun.

    PNAS 111(42):14964 (2014) PMID 25271327 PMCID PMC4210301

  12. Woody Hastings.

    Journal of Biological Rhythms 29(5):315 (2014) PMID 25332348

  13. Woody Hastings.

    Journal of Biological Rhythms 29(5):315 (2014) PMID 25332348

  14. Carl Hirschie Johnson

    Current Biology 24(3):R100 (2014)

  15. Carl Hirschie Johnson

    Current Biology 24(3):R100 (2014)

  16. A microfluidic-enabled mechanical microcompressor for the immobilization of live single- and multi-cellular specimens.

    Microscopy and Microanalysis 20(1):141 (2014) PMID 24444078 PMCID PMC4026272

    A microcompressor is a precision mechanical device that flattens and immobilizes living cells and small organisms for optical microscopy, allowing enhanced visualization of sub-cellular structures and organelles. We have developed an easily fabricated device, which can be equipped with microflui...
  17. A microfluidic-enabled mechanical microcompressor for the immobilization of live single- and multi-cellular specimens.

    Microscopy and Microanalysis 20(1):141 (2014) PMID 24444078 PMCID PMC4026272

    A microcompressor is a precision mechanical device that flattens and immobilizes living cells and small organisms for optical microscopy, allowing enhanced visualization of sub-cellular structures and organelles. We have developed an easily fabricated device, which can be equipped with microflui...
  18. Metabolic compensation and circadian resilience in prokaryotic cyanobacteria.

    Biochemistry 83:221 (2014) PMID 24905782 PMCID PMC4259047

    For a biological oscillator to function as a circadian pacemaker that confers a fitness advantage, its timing functions must be stable in response to environmental and metabolic fluctuations. One such stability enhancer, temperature compensation, has long been a defining characteristic of these ...
  19. Metabolic compensation and circadian resilience in prokaryotic cyanobacteria.

    Biochemistry 83:221 (2014) PMID 24905782 PMCID PMC4259047

    For a biological oscillator to function as a circadian pacemaker that confers a fitness advantage, its timing functions must be stable in response to environmental and metabolic fluctuations. One such stability enhancer, temperature compensation, has long been a defining characteristic of these ...
  20. Metabolic compensation and circadian resilience in prokaryotic cyanobacteria.

    Biochemistry 83:221 (2014) PMID 24905782 PMCID PMC4259047

    For a biological oscillator to function as a circadian pacemaker that confers a fitness advantage, its timing functions must be stable in response to environmental and metabolic fluctuations. One such stability enhancer, temperature compensation, has long been a defining characteristic of these ...