1. A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression.

    Cell Host & Microbe 17(6):741 (2015) PMID 26067602

    During red-blood-cell-stage infection of Plasmodium falciparum, the parasite undergoes repeated rounds of replication, egress, and invasion. Erythrocyte invasion involves specific interactions between host cell receptors and parasite ligands and coordinated expression of genes specific to this s...
  2. Advances in molecular genetic systems in malaria.

    Nature Reviews: Microbiology 13(6):373 (2015) PMID 25978707

    Robust tools for analysing gene function in Plasmodium parasites, which are the causative agents of malaria, are being developed at an accelerating rate. Two decades after genetic technologies for use in Plasmodium spp. were first described, a range of genetic tools are now available. These incl...
  3. Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites.

    ACS Chemical Biology 10(4):1145 (2015) PMID 25555060

    Apicomplexan parasites, including Plasmodium falciparum and Toxoplasma gondii, the causative agents of severe malaria and toxoplasmosis, respectively, undergo several critical developmental transitions during their lifecycle. Most important for human pathogenesis is the asexual cycle, in which p...
  4. Why Australia needs a Medical Research Future Fund.

    Medical Journal of Australia 202(3):123 (2015) PMID 25669464

  5. Why Australia needs a Medical Research Future Fund.

    Medical Journal of Australia 202(3):123 (2015) PMID 25669464

  6. Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes.

    PLoS Pathogens 11(2):e1004670 (2015) PMID 25723550 PMCID PMC4344246

    During blood stage Plasmodium falciparum infection, merozoites invade uninfected erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand binding events. Understanding each element in this process increases the potential to block the parasite's life cycle via ...
  7. Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes.

    PLoS Pathogens 11(2):e1004670 (2015) PMID 25723550 PMCID PMC4344246

    During blood stage Plasmodium falciparum infection, merozoites invade uninfected erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand binding events. Understanding each element in this process increases the potential to block the parasite's life cycle via ...
  8. Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.

    BMC Biology 13:52 (2015) PMID 26187647 PMCID PMC4506589

    Malaria invasion of red blood cells involves multiple parasite-specific targets that are easily accessible to inhibitory compounds, making it an attractive target for antimalarial development. However, no current antimalarial agents act against host cell invasion. Here, we demonstrate that the c...
  9. Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1.

    International Journal for Parasitology 44(12):853 (2014) PMID 25157917

    Apicomplexan parasites are obligate intracellular pathogens that cause a host of human and animal diseases. These parasites have developed a universal mechanism of invasion involving formation of a 'moving junction' that provides a stable anchoring point through which the parasite invades host c...
  10. Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1.

    International Journal for Parasitology 44(12):853 (2014) PMID 25157917

    Apicomplexan parasites are obligate intracellular pathogens that cause a host of human and animal diseases. These parasites have developed a universal mechanism of invasion involving formation of a 'moving junction' that provides a stable anchoring point through which the parasite invades host c...
  11. Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1.

    International Journal for Parasitology 44(12):853 (2014) PMID 25157917

    Apicomplexan parasites are obligate intracellular pathogens that cause a host of human and animal diseases. These parasites have developed a universal mechanism of invasion involving formation of a 'moving junction' that provides a stable anchoring point through which the parasite invades host c...
  12. PTEX is an essential nexus for protein export in malaria parasites.

    Nature 511(7511):587 (2014) PMID 25043043

    During the blood stages of malaria, several hundred parasite-encoded proteins are exported beyond the double-membrane barrier that separates the parasite from the host cell cytosol. These proteins have a variety of roles that are essential to virulence or parasite growth. There is keen interest ...
  13. PTEX is an essential nexus for protein export in malaria parasites.

    Nature 511(7511):587 (2014) PMID 25043043

    During the blood stages of malaria, several hundred parasite-encoded proteins are exported beyond the double-membrane barrier that separates the parasite from the host cell cytosol. These proteins have a variety of roles that are essential to virulence or parasite growth. There is keen interest ...
  14. Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites.

    Cellular Microbiology 16(5):642 (2014) PMID 24571085

    Malaria is caused by obligate intracellular parasites, of which Plasmodium falciparum is the most lethal species. In humans, P.  falciparum merozoites (invasive forms of the parasite) employ a host of parasite proteins to rapidly invade erythrocytes. One of these is the P.  falciparum apical mem...
  15. CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria.

    PLoS Pathogens 10(5):e1004135 (2014) PMID 24854165 PMCID PMC4031232

    To follow the fate of CD8+ T cells responsive to Plasmodium berghei ANKA (PbA) infection, we generated an MHC I-restricted TCR transgenic mouse line against this pathogen. T cells from this line, termed PbT-I T cells, were able to respond to blood-stage infection by PbA and two other rodent mala...
  16. Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites.

    Cellular Microbiology 16(5):642 (2014) PMID 24571085 PMCID PMC4231980

    Malaria is caused by obligate intracellular parasites, of which Plasmodium falciparum is the most lethal species. In humans, P.  falciparum merozoites (invasive forms of the parasite) employ a host of parasite proteins to rapidly invade erythrocytes. One of these is the P.  falciparum apical mem...
  17. Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites.

    Cellular Microbiology 16(5):642 (2014) PMID 24571085 PMCID PMC4231980

    Malaria is caused by obligate intracellular parasites, of which Plasmodium falciparum is the most lethal species. In humans, P.  falciparum merozoites (invasive forms of the parasite) employ a host of parasite proteins to rapidly invade erythrocytes. One of these is the P.  falciparum apical mem...
  18. CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria.

    PLoS Pathogens 10(5):e1004135 (2014) PMID 24854165 PMCID PMC4031232

    To follow the fate of CD8+ T cells responsive to Plasmodium berghei ANKA (PbA) infection, we generated an MHC I-restricted TCR transgenic mouse line against this pathogen. T cells from this line, termed PbT-I T cells, were able to respond to blood-stage infection by PbA and two other rodent mala...
  19. Protein export in malaria parasites: an update.

    Cellular Microbiology 16(3):355 (2014) PMID 24418476

    Symptomatic malaria is caused by the infection of human red blood cells (RBCs) with Plasmodium parasites. The RBC is a peculiar environment for parasites to thrive in as they lack many of the normal cellular processes and resources present in other cells. Because of this, Plasmodium spp. have ad...
  20. Protein export in malaria parasites: an update.

    Cellular Microbiology 16(3):355 (2014) PMID 24418476

    Symptomatic malaria is caused by the infection of human red blood cells (RBCs) with Plasmodium parasites. The RBC is a peculiar environment for parasites to thrive in as they lack many of the normal cellular processes and resources present in other cells. Because of this, Plasmodium spp. have ad...