1. Structure-Activity Relationship of Azaindole-Based Glucokinase Activators.

    Journal of medicinal and pharmaceutical chemistry 59(2):687 (2016) PMID 26685731

    7-Azaindole has been identified as a novel bidentate anchor point for allosteric glucokinase activators. A systematic investigation around three principal parts of the new small molecule glucokinase activators led to a robust SAR in agreement with structural data that also helped to assess the c...
  2. Modular synthesis of heterocyclic carbene precursors.

    Journal of Organic Chemistry 71(16):5969 (2006) PMID 16872179

    A series of N-heterocyclic carbene precursors, containing an imidazoline or tetrahydropyrimidine framework, were prepared from omega-chloroalkanoyl chlorides. The sequential attachment of nitrogen nucleophiles and subsequent ring closure gave, depending on the reagents used, either the desired d...