1. Dietary Supplementation with Isoflavones Prevents Muscle Wasting in Tumor-Bearing Mice.

    Journal of Nutritional Science and Vitaminology 62(3):178 (2016) PMID 27465724

    Proinflammatory cytokines contribute to the progression of muscle wasting caused by ubiquitin-proteasome-dependent proteolysis. We have previously demonstrated that isoflavones, such as genistein and daidzein, prevent TNF-α-induced muscle atrophy in C2C12 myotubes. In this study, we examined the...
  2. Reduction of gibberellin by low temperature disrupts pollen development in rice.

    Plant Physiology 164(4):2011 (2014) PMID 24569847 PMCID PMC3982758

    Microsporogenesis in rice (Oryza sativa) plants is susceptible to moderate low temperature (LT; approximately 19°C) that disrupts pollen development and causes severe reductions in grain yields. Although considerable research has been invested in the study of cool-temperature injury, a full unde...
  3. Caenorhabditis elegans ATR checkpoint kinase ATL-1 influences life span through mitochondrial maintenance

    Mitochondrion 13(6):729 (2013)

    ATR is highly conserved in all eukaryotes and functions as a cell-cycle nuclear checkpoint kinase. In mammals, ATR is essential whose complete absence results in early embryonic lethality and its hypomorphic mutation causes a complex disease known as Seckel syndrome. However, molecular...
  4. Isolation of a novel mutant gene for soil-surface rooting in rice (Oryza sativa L.).

    Rice 6(1):30 (2013) PMID 24280269 PMCID PMC3874653

    Root system architecture is an important trait affecting the uptake of nutrients and water by crops. Shallower root systems preferentially take up nutrients from the topsoil and help avoid unfavorable environments in deeper soil layers. We have found a soil-surface rooting mutant from an M2 popu...
  5. High temperature injury and auxin biosynthesis in microsporogenesis.

    Frontiers in Plant Science 4:47 (2013) PMID 23483842 PMCID PMC3593198

    Plant reproductive development is more sensitive than vegetative growth to many environmental stresses. High temperature (HT) injury is becoming an increasingly serious problem due to recent global warming. In wheat, barley, and other crops, the early phase of anther development is most suscepti...
  6. Mapping and characterization of quantitative trait loci for mesocotyl elongation in rice (Oryza sativa L.).

    Rice 5(1):13 (2012) PMID 27234239

    Mesocotyl elongation is an important trait for seedling emergence in direct-seeding cultivation in rice. In this study, a backcross inbred line (BIL) population from a cross between Kasalath and Nipponbare was employed to map quantitative trait loci (QTLs) for mesocotyl elongation. A total of 5 ...
  7. Innate immune genes including a mucin-like gene, mul-1, induced by ionizing radiation in Caenorhabditis elegans.

    Radiation Research 178(4):313 (2012) PMID 22967128

    The effect of radiation on the intestine has been studied for more than one hundred years. It remains unclear, however, whether this organ uses specific defensive mechanisms against ionizing radiation. The infection with Pseudomonas aeruginosa (PA14) in Caenorhabditis elegans induces up-regu...
  8. CDC-48/p97 is required for proper meiotic chromosome segregation via controlling AIR-2/Aurora B kinase localization in Caenorhabditis elegans.

    Journal of Structural Biology 179(2):104 (2012) PMID 22735043

    CDC-48/p97 is a AAA (ATPases associated with diverse cellular activities) chaperone involved in protein conformational changes such as the disassembly of protein complexes. We previously reported that Caenorhabditis elegans CDC-48.1 and CDC-48.2 (CDC-48s) are essential for the progression of mei...
  9. Impaired development of melanoblasts in the black-eyed white Mitf(mi-bw) mouse, a model for auditory-pigmentary disorders.

    Genes to Cells 17(6):494 (2012) PMID 22563733

    Microphthalmia-associated transcription factor (Mitf) is a regulator for differentiation of melanoblasts that are derived from the neural crest. The mouse homozygous for the black-eyed white (Mitf(mi-bw)) allele is characterized by the white coat color and deafness, with black eye that is associ...
  10. Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.

    Scientific reports 2:487 (2012) PMID 22768380 PMCID PMC3390002

    How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each...
  11. The next phase of life-sciences spaceflight research: Harnessing the power of functional genomics.

    Communicative & Integrative Biology 4(6):668 (2011) PMID 22446523 PMCID PMC3306327

    Recently we demonstrated that the effectiveness of RNAi interference (RNAi) for inhibiting gene expression is maintained during spaceflight in the worm Caenorhabditis elegans and argued for the biomedical importance of this finding. We also successfully utilized green fluorescent protein (GFP)-t...
  12. Auxin depletion in barley plants under high-temperature conditions represses DNA proliferation in organelles and nuclei via transcriptional alterations.

    Plant, Cell & Environment 34(2):284 (2011) PMID 20955225

    Many plant species are susceptible to high-temperature (HT) injury during reproductive development. We recently demonstrated that HT represses the expression of YUCCA auxin biosynthesis genes and reduces endogenous auxin in the developing anthers of barley and Arabidopsis. Here, we show that DNA...
  13. The effectiveness of RNAi in Caenorhabditis elegans is maintained during spaceflight.

    PLoS ONE 6(6):e20459 (2011) PMID 21673804 PMCID PMC3105993

    Overcoming spaceflight-induced (patho)physiologic adaptations is a major challenge preventing long-term deep space exploration. RNA interference (RNAi) has emerged as a promising therapeutic for combating diseases on Earth; however the efficacy of RNAi in space is currently unknown. Caenorhabdit...
  14. Tissue-specific auxin signaling in response to temperature fluctuation.

    Plant Signaling & Behavior 5(11):1510 (2010) PMID 21051957 PMCID PMC3115269

    Auxin levels are well regulated in cells and tissues by both transport and local biosynthesis, and its distribution is important for the modulation of cell proliferation, differentiation, development, tropisms and high-temperature response. Activation of auxin biosynthesis with increased tempera...
  15. Radiation biology of Caenorhabditis elegans: germ cell response, aging and behavior.

    Journal of Radiation Research 51(2):107 (2010) PMID 20208402

    The study of radiation effect in Caenorhabditis (C.) elegans has been carried out over three decades and now allow for understanding at the molecular, cellular and individual levels. This review describes the current knowledge of the biological effects of ionizing irradiation with a scope of the...
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  16. High temperatures cause male sterility in rice plants with transcriptional alterations during pollen development.

    Plant and Cell Physiology 50(11):1911 (2009) PMID 19808807

    Plant male reproductive development is highly organized and sensitive to various environmental stressors, including high temperature. We have established an experimental procedure to evaluate high temperature injury in japonica rice plants. High temperature treatment (39 degrees C/30 degrees C) ...
  17. Caenorhabditis elegans p97 controls germline-specific sex determination by controlling the TRA-1 level in a CUL-2-dependent manner.

    Journal of Cell Science 122(Pt 20):3663 (2009) PMID 19773360

    p97 (CDC-48 in Caenorhabditis elegans) is a ubiquitin-selective AAA (ATPases associated with diverse cellular activities) chaperone and its key function is to disassemble protein complexes. p97 functions in diverse cellular processes including endoplasmic reticulum (ER)-associated degradation, m...
  18. Localization of X-ray cross complementing gene 1 protein in the nuclear matrix is controlled by casein kinase II-dependent phosphorylation in response to oxidative damage.

    DNA Repair 8(8):953 (2009) PMID 19596613

    Base excision repair/single strand break repair (BER/SSBR) of damaged DNA is a highly efficient process. X-ray cross complementing protein 1 (XRCC1) functions as a key scaffold protein for BER/SSBR factors. Recent work has shown that XRCC1 forms dense foci at sites of DNA damage in a manner depe...
  19. Effects of ionizing radiation on locomotory behavior and mechanosensation in Caenorhabditis elegans.

    Journal of Radiation Research 50(2):119 (2009) PMID 19194068

    Locomotory behavior (motility) and mechanosensation are of vital importance in animals. We examined the effects of ionizing radiation (IR) on locomotory behavior and mechanosensation using a model organism, the nematode Caenorhabditis elegans. Bacterial mechanosensation in C. elegans induces the...
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  20. Nitrous oxide emission and microbial community in the rhizosphere of nodulated soybeans during the late growth period.

    Microbes and Environments 24(1):64 (2009) PMID 21566356

    We examined N(2)O emissions from the rhizosphere of field-grown soybeans during the late growth stage (99-117 days after sowing). Marked emissions were detected from the nodulated root systems of field-grown soybeans, whereas a non-nodulating soybean mutant showed no emission. Degraded nodules e...