Efficacy and Safety of Pyronaridine-Artesunate for Treatment of Uncomplicated Plasmodium falciparum Malaria in Western Cambodia.
Antimicrobial Agents and Chemotherapy 60(7):3884 (2016)
Pyronaridine-artesunate efficacy for the treatment of uncomplicated Plasmodium falciparum malaria was assessed in an area of artemisinin resistance in western Cambodia. This nonrandomized, single-arm, observational study was conducted between 2014 and 2015. Eligible patients were adults or child...
Artemisinin-Resistant Plasmodium falciparum Malaria.
Microbiology spectrum 4(3) (2016)
For more than five decades, Southeast Asia (SEA) has been fertile ground for the emergence of drug-resistant Plasmodium falciparum malaria. After generating parasites resistant to chloroquine, sulfadoxine, pyrimethamine, quinine, and mefloquine, this region has now spawned parasites resistant to...
Retinal Changes in Uncomplicated and Severe Plasmodium knowlesi Malaria.
Journal of Infectious Diseases 213(9):1476 (2016)
Plasmodium knowlesi causes severe malaria, but its pathogenesis is poorly understood. Retinal changes provide insights into falciparum malaria pathogenesis but have not been studied in knowlesi malaria.
An observational study was conducted in Malaysian adults hospitalized with severe (n = 20) an...
Sequestration and Red Cell Deformability as Determinants of Hyperlactatemia in Falciparum Malaria.
Journal of Infectious Diseases 213(5):788 (2016)
Hyperlactatemia is a strong predictor of mortality in severe falciparum malaria. Sequestered parasitized erythrocytes and reduced uninfected red blood cell deformability (RCD) compromise microcirculatory flow, leading to anaerobic glycolysis.
In a cohort of patients with falciparum malaria hospi...
Critical Care in Resource-Restricted Settings.
JAMA 315(8):753 (2016)
Use of Blood Smears and Dried Blood Spots for Polymerase Chain Reaction-Based Detection and Quantification of Bacterial Infection and Plasmodium falciparum in Severely Ill Febrile African Children.
The Journal of tropical medicine and hygiene 94(2):322 (2016)
Molecular approaches offer a means of testing archived samples stored as dried blood spots in settings where standard blood cultures are not possible. Peripheral blood films are one suggested source of material, although the sensitivity of this approach has not been well defined. Thin blood smea...
The Relationship between Poverty and Healthcare Seeking among Patients Hospitalized with Acute Febrile Illnesses in Chittagong, Bangladesh.
PLoS ONE 11(4):e0152965 (2016)
Delays in seeking appropriate healthcare can increase the case fatality of acute febrile illnesses, and circuitous routes of care-seeking can have a catastrophic financial impact upon patients in low-income settings. To investigate the relationship between poverty and pre-hospital delays for pat...
Clinical trials of artesunate plus sulfadoxine-pyrimethamine for Plasmodium falciparum malaria in Afghanistan: maintained efficacy a decade after introduction.
Malaria Journal 15(1):121 (2016)
Combination therapy with artesunate plus sulfadoxine-pyrimethamine (SP) was adopted as recommended treatment for Plasmodium falciparum infection in Afghanistan in 2003.
A series of prospective clinical studies examining the efficacy of artesunate plus sulfadoxine-pyrimethamine (AS + SP) against ...
The Cambodia Research Consortium: expediting research for malaria elimination with the emergency response to artemisinin resistance framework.
Malaria Journal 15(1):5 (2016)
This commentary offers insight into how to best address barriers that may hinder the translation of malaria research findings into policy. It also proposes viable methods of implementing these policies in Cambodia. Currently, a wide range of malaria research is being conducted by in-country stak...
Establishing research priorities for malaria elimination in the context of the emergency response to artemisinin resistance framework-the Cambodian approach.
Malaria Journal 15(1):120 (2016)
Countries of the greater Mekong subregion have made a transition from malaria control to an aim for falciparum and vivax malaria elimination. The elimination of falciparum malaria will have to be achieved against a background of increasing artemisinin and multi-drug resistance. This ambitious go...
Parasite clearance rates in Upper Myanmar indicate a distinctive artemisinin resistance phenotype: a therapeutic efficacy study.
Malaria Journal 15(1):185 (2016)
Artemisinin resistance in Plasmodium falciparum extends across Southeast Asia where it is associated with worsening partner drug resistance and a decline in the efficacy of frontline artemisinin-based combination therapy. Dihydroartemisinin-piperaquine (DP) is an essential component of preventiv...
Asymptomatic Plasmodium infections in 18 villages of southern Savannakhet Province, Lao PDR (Laos).
Malaria Journal 15(1):296 (2016)
A large fraction of Plasmodium infections do not cause clinical signs and symptoms of disease and persist at densities in blood that are not detectable by microscopy or rapid diagnostic tests. These infections may be critical as a transmission reservoir in areas of low malaria endemicity. Unders...
Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria.
Malaria Journal 15(1):244 (2016)
Fever is an inherent symptom of malaria in both adults and children. Paracetamol (acetaminophen) is the recommended antipyretic as it is inexpensive, widely available and has a good safety profile, but patients may not be able to take the oral drug reliably. A comparison between the pharmacokine...
Persistent Plasmodium falciparum and Plasmodium vivax infections in a western Cambodian population: implications for prevention, treatment and elimination strategies.
Malaria Journal 15(1):181 (2016)
Subclinical Plasmodium parasitaemia is an important reservoir for the transmission and persistence of malaria, particularly in low transmission areas.
Using ultrasensitive quantitative PCR (uPCR) for the detection of parasitaemia, the entire population of three Cambodian villages in Pailin provi...
Association between Subclinical Malaria Infection and Inflammatory Host Response in a Pre-Elimination Setting.
PLoS ONE 11(7):e0158656 (2016)
Subclinical infections in endemic areas of Southeast Asia sustain malaria transmission. These asymptomatic infections might sustain immunity against clinical malaria and have been considered benign for the host, but if they are associated with chronic low-grade inflammation this could be harmful...
Assessing the impact of next-generation rapid diagnostic tests on Plasmodium falciparum malaria elimination strategies.
Nature 528(7580):S94 (2015)
Mass-screen-and-treat and targeted mass-drug-administration strategies are being considered as a means to interrupt transmission of Plasmodium falciparum malaria. However, the effectiveness of such strategies will depend on the extent to which current and future diagnostics are able to detect th...
Soluble and cell-associated triggering receptor expressed on myeloid cells-1 and -2 in patients with pulmonary tuberculosis.
Journal of Infection 71(6):706 (2015)
Optimum population-level use of artemisinin combination therapies: a modelling study.
The lancet global health 3(12):e758 (2015)
Artemisinin combination therapies (ACTs) are used worldwide as first-line treatment against confirmed or suspected Plasmodium falciparum malaria. Despite the success of ACTs at reducing the global burden of malaria, emerging resistance to artemisinin threatens these gains. Countering onset of re...
Artemisinin resistance in Myanmar--Authors' reply.
The Lancet Infectious Diseases 15(9):1002 (2015)
Increased intra- and extracellular granzyme expression in patients with tuberculosis.
Tuberculosis 95(5):575 (2015)
Tuberculosis (TB) is an important cause of morbidity and mortality worldwide. Granzymes (gzms) are proteases mainly found in cytotoxic lymphocytes, but also extracellularly. While the role of gzms in target cell death has been widely characterized, considerable evidence points towards broader ro...