1. In Vitro Antibacterial Activity of the Ceftazidime-Avibactam Combination against Enterobacteriaceae, Including Strains with Well-Characterized β-Lactamases.

    Antimicrobial Agents and Chemotherapy 59(4):1931 (2015) PMID 25583732

    The novel β-lactamase inhibitor avibactam is a potent inhibitor of class A, class C, and some class D enzymes. The in vitro antibacterial activity of the ceftazidime-avibactam combination was determined for a collection of Enterobacteriaceae clinical isolates; this collection was enriched for re...
  2. Efficacy of a Ceftazidime-Avibactam combination in a murine model of Septicemia caused by Enterobacteriaceae species producing ampc or extended-spectrum β-lactamases.

    Antimicrobial Agents and Chemotherapy 58(11):6490 (2014) PMID 25136016 PMCID PMC4249388

    Avibactam is a novel non-β-lactam β-lactamase inhibitor that has been shown in vitro to inhibit class A, class C, and some class D β-lactamases. It is currently in phase 3 of clinical development in combination with ceftazidime. In this study, the efficacy of ceftazidime-avibactam was evaluated ...
  3. Efficacy of a Ceftazidime-Avibactam combination in a murine model of Septicemia caused by Enterobacteriaceae species producing ampc or extended-spectrum β-lactamases.

    Antimicrobial Agents and Chemotherapy 58(11):6490 (2014) PMID 25136016

    Avibactam is a novel non-β-lactam β-lactamase inhibitor that has been shown in vitro to inhibit class A, class C, and some class D β-lactamases. It is currently in phase 3 of clinical development in combination with ceftazidime. In this study, the efficacy of ceftazidime-avibactam was evaluated ...
  4. Activities of ceftazidime and avibactam against β-lactamase-producing Enterobacteriaceae in a hollow-fiber pharmacodynamic model.

    Antimicrobial Agents and Chemotherapy 58(6):3366 (2014) PMID 24687507 PMCID PMC4068505

    Avibactam is a novel non-β-lactam β-lactamase inhibitor that is currently undergoing phase 3 clinical trials in combination with ceftazidime. Ceftazidime is hydrolyzed by a broad range of β-lactamases, but avibactam is able to inhibit the majority of these enzymes. The studies described here att...
  5. International test results for objective lens quality, resolution, spectral accuracy and spectral separation for confocal laser scanning microscopes.

    Microscopy and Microanalysis 19(6):1653 (2013) PMID 24103552

    As part of an ongoing effort to increase image reproducibility and fidelity in addition to improving cross-instrument consistency, we have proposed using four separate instrument quality tests to augment the ones we have previously reported. These four tests assessed the following areas: (1) obj...
  6. In vitro antibacterial activity of the ceftazidime-avibactam (NXL104) combination against Pseudomonas aeruginosa clinical isolates.

    Antimicrobial Agents and Chemotherapy 56(3):1606 (2012) PMID 22214778 PMCID PMC3294935

    The β-lactamase inhibitor avibactam (NXL104) displays potent inhibition of both class A and C enzymes. The in vitro antibacterial activity of the combination ceftazidime-avibactam was evaluated against a clinical panel of Pseudomonas aeruginosa isolates. Avibactam offered efficient protection fr...
  7. In vitro antibacterial activity of the ceftazidime-avibactam (NXL104) combination against Pseudomonas aeruginosa clinical isolates.

    Antimicrobial Agents and Chemotherapy 56(3):1606 (2012) PMID 22214778 PMCID PMC3294935

    The β-lactamase inhibitor avibactam (NXL104) displays potent inhibition of both class A and C enzymes. The in vitro antibacterial activity of the combination ceftazidime-avibactam was evaluated against a clinical panel of Pseudomonas aeruginosa isolates. Avibactam offered efficient protection fr...
  8. Quality assurance testing for modern optical imaging systems.

    Microscopy and Microanalysis 17(4):598 (2011) PMID 21477410

    The days of being able to ascertain instrument performance by simply peering through the eye pieces at a specimen are gone. However, users and granting agencies need to be confident that data collected on these instruments is uniform and quantifiable both over time and between instruments. Ideal...
  9. In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases.

    Journal of Antimicrobial Chemotherapy 64(2):326 (2009) PMID 19493866 PMCID PMC2707266

    NXL104 is a novel-structure beta-lactamase inhibitor with potent activity against both class A and class C enzymes. Among the class A carbapenemases, KPC-type enzymes are now spreading rapidly and KPC-related carbapenemase resistance is an emerging phenomenon of great clinical importance. The ac...
  10. In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases.

    Journal of Antimicrobial Chemotherapy 64(2):326 (2009) PMID 19493866 PMCID PMC2707266

    NXL104 is a novel-structure beta-lactamase inhibitor with potent activity against both class A and class C enzymes. Among the class A carbapenemases, KPC-type enzymes are now spreading rapidly and KPC-related carbapenemase resistance is an emerging phenomenon of great clinical importance. The ac...
  11. Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases.

    Antimicrobial Agents and Chemotherapy 52(9):3339 (2008) PMID 18625781 PMCID PMC2533460

    NXL101 is one of a new class of quinoline antibacterial DNA gyrase and topoisomerase IV inhibitors showing potent activity against gram-positive bacteria, including methicillin- and fluoroquinolone-resistant strains. NXL101 inhibited topoisomerase IV more effectively than gyrase from Escherichia...
  12. The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication.

    Journal of Biological Chemistry 282(16):12048 (2007) PMID 17317667

    The Werner syndrome helicase (WRN) participates in DNA replication, double strand break repair, telomere maintenance, and p53 activation. Mutations of wrn cause Werner syndrome (WS), an autosomal recessive premature aging disorder associated with cancer predisposition, atherosclerosis, and other...
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  13. A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.

    Molecular and Cellular Biology 25(14):6178 (2005) PMID 15988028 PMCID PMC1168837

    The human T-cell lymphotropic virus type 1 (HTLV-1) infects and transforms CD4+ lymphocytes and causes adult T-cell leukemia/lymphoma (ATLL), an aggressive lymphoproliferative disease that is often fatal. Here, we demonstrate that the HTLV-1 pX splice-variant p30II markedly enhances the transfor...
  14. [Backward flow of blood in the extracorporal circuit pressure transducers of the generator-monitors of hemodialysis].

    Néphrologie & Thérapeutique 1(3):157 (2005) PMID 16895681

    Transmission of hepatitis C virus between hemodialysis patients occurs mainly between the patients treated simultaneously in the same sector or in the same room. The other mode of viral transmission occurs between two patients treated successively with the same hemodialysis generator-monitor and...
  15. Inondation des capteurs de pression sanguine des générateurs–moniteurs d'hémodialyse

    Néphrologie & Thérapeutique 1(3):157 (2005)

    La transmission du virus de l'hépatite C dans une unité d'hémodialyse peut se faire de plusieurs façons. Le mode de transmission principal se fait entre les malades traités simultanément dans le même secteur ou dans la même chambre. L'autre mode de transmission virale se fait entre deux mal...
  16. Inhibitors of Civ1 kinase belonging to 6-aminoaromatic-2-cyclohexyldiamino purine series as potent anti-fungal compounds.

    Biochimica et Biophysica Acta 1697(1-2):211 (2004) PMID 15023362

    There is today a blatant need for new antifungal agents, because of the recent increase in life-threatening infections involving an ever-greater number of fungal strains. Fungi make extensive use of kinases in the regulation of essential processes, in particular the cell cycle. Most fungal kinas...
  17. Inhibitors of Civ1 kinase belonging to 6-aminoaromatic-2-cyclohexyldiamino purine series as potent anti-fungal compounds

    Biochimica et Biophysica Acta (BBA) - Proteins ... 1697(1):211 (2004)

    There is today a blatant need for new antifungal agents, because of the recent increase in life-threatening infections involving an ever-greater number of fungal strains. Fungi make extensive use of kinases in the regulation of essential processes, in particular the cell cycle. Most fungal ...
  18. In vitro maturation of human oocytes with growth hormone

    Fertility and Sterility 80:277 (2003)

  19. In vitro maturation of human oocytes with growth hormone

    Fertility and Sterility 80:277 (2003)