1. ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.

    Molecular and Cellular Biology 35(8):1462 (2015) PMID 25691660 PMCID PMC4372706

    Signaling via the pre-T-cell receptor (pre-TCR), along with associated signals from Notch and chemokine receptors, regulates the β-selection checkpoint that operates on CD4(-) CD8(-) doubly negative (DN) thymocytes. Since many hematopoietic malignancies arise at the immature developmental stages...
  2. Abl Kinases Regulate HGF/Met Signaling Required for Epithelial Cell Scattering, Tubulogenesis and Motility.

    PLoS ONE 10(5):e0124960 (2015) PMID 25946048 PMCID PMC4422589

    Tight regulation of receptor tyrosine kinases (RTKs) is crucial for normal development and homeostasis. Dysregulation of RTKs signaling is associated with diverse pathological conditions including cancer. The Met RTK is the receptor for hepatocyte growth factor (HGF) and is dysregulated in numer...
  3. Targeting ABL1-Mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer

    Cancer Cell 26(6):840 (2014)

    Patients with germline fumarate hydratase (FH) mutation are predisposed to develop aggressive kidney cancer with few treatment options and poor therapeutic outcomes. Activity of the proto-oncogene ABL1 is upregulated in FH-deficient kidney tumors and drives a metabolic and survival sig...
  4. Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.

    Cancer Cell 26(6):840 (2014) PMID 25490448

    Patients with germline fumarate hydratase (FH) mutation are predisposed to develop aggressive kidney cancer with few treatment options and poor therapeutic outcomes. Activity of the proto-oncogene ABL1 is upregulated in FH-deficient kidney tumors and drives a metabolic and survival signaling net...
  5. Targeting ABL1-Mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer.

    Cancer Cell 26(6):840 (2014) PMID 25490448

    Patients with germline fumarate hydratase (FH) mutation are predisposed to develop aggressive kidney cancer with few treatment options and poor therapeutic outcomes. Activity of the proto-oncogene ABL1 is upregulated in FH-deficient kidney tumors and drives a metabolic and survival signaling net...
  6. Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.

    Cancer Cell 26(6):840 (2014) PMID 25490448

    Patients with germline fumarate hydratase (FH) mutation are predisposed to develop aggressive kidney cancer with few treatment options and poor therapeutic outcomes. Activity of the proto-oncogene ABL1 is upregulated in FH-deficient kidney tumors and drives a metabolic and survival signaling net...
  7. Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.

    Cancer Cell 26(6):840 (2014) PMID 25490448

    Patients with germline fumarate hydratase (FH) mutation are predisposed to develop aggressive kidney cancer with few treatment options and poor therapeutic outcomes. Activity of the proto-oncogene ABL1 is upregulated in FH-deficient kidney tumors and drives a metabolic and survival signaling net...
  8. Targeting ABL1-mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer

    Cancer Cell (2014)

    Patients with germline fumarate hydratase (FH) mutation are predisposed to develop aggressive kidney cancer with few treatment options and poor therapeutic outcomes. Activity of the proto-oncogene ABL1 is upregulated in FH-deficient kidney tumors and drives a metabolic and survival sig...
  9. Targeting ABL1-mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer

    Cancer Cell (2014)

    Patients with germline fumarate hydratase (FH) mutation are predisposed to develop aggressive kidney cancer with few treatment options and poor therapeutic outcomes. Activity of the proto-oncogene ABL1 is upregulated in FH-deficient kidney tumors and drives a metabolic and survival sig...
  10. Targeting ABL1-mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer

    Cancer Cell (2014)

    Patients with germline fumarate hydratase (FH) mutation are predisposed to develop aggressive kidney cancer with few treatment options and poor therapeutic outcomes. Activity of the proto-oncogene ABL1 is upregulated in FH-deficient kidney tumors and drives a metabolic and survival sig...
  11. Tie2 (to) Abl: Signaling to endothelial cell survival.

    Cell Cycle 12(24):3709 (2013) PMID 24145226 PMCID PMC3905057

  12. Tie2 (to) Abl: Signaling to endothelial cell survival.

    Cell Cycle 12(24):3709 (2013) PMID 24145226 PMCID PMC3905057

  13. Role of ABL family kinases in cancer: from leukaemia to solid tumours.

    Nature Reviews: Cancer 13(8):559 (2013) PMID 23842646 PMCID PMC3935732

    The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces diverse extracellular signals to protein networks that control proliferation, survival, migration and invasion. ABL1 was first identified as an oncogene required for the development of leukaemias initiated by ret...
  14. Role of ABL family kinases in cancer: from leukaemia to solid tumours.

    Nature Reviews: Cancer 13(8):559 (2013) PMID 23842646 PMCID PMC3935732

    The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces diverse extracellular signals to protein networks that control proliferation, survival, migration and invasion. ABL1 was first identified as an oncogene required for the development of leukaemias initiated by ret...
  15. Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival.

    PNAS 110(30):12432 (2013) PMID 23840065 PMCID PMC3725093

    Endothelial dysfunction is associated with diverse cardiovascular pathologies. Here, we show a previously unappreciated role for the Abelson (Abl) family kinases (Abl and Arg) in endothelial function and the regulation of angiogenic factor pathways important for vascular homeostasis. Endothelial...
  16. Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival.

    PNAS 110(30):12432 (2013) PMID 23840065 PMCID PMC3725093

    Endothelial dysfunction is associated with diverse cardiovascular pathologies. Here, we show a previously unappreciated role for the Abelson (Abl) family kinases (Abl and Arg) in endothelial function and the regulation of angiogenic factor pathways important for vascular homeostasis. Endothelial...
  17. Abl family kinases regulate endothelial barrier function in vitro and in mice.

    PLoS ONE 8(12):e85231 (2013) PMID 24367707 PMCID PMC3868616

    The maintenance of endothelial barrier function is essential for normal physiology, and increased vascular permeability is a feature of a wide variety of pathological conditions, leading to complications including edema and tissue damage. Use of the pharmacological inhibitor imatinib, which targ...
  18. Abl family kinases regulate endothelial barrier function in vitro and in mice.

    PLoS ONE 8(12):e85231 (2013) PMID 24367707 PMCID PMC3868616

    The maintenance of endothelial barrier function is essential for normal physiology, and increased vascular permeability is a feature of a wide variety of pathological conditions, leading to complications including edema and tissue damage. Use of the pharmacological inhibitor imatinib, which targ...
  19. Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages.

    Journal of Immunology 189(11):5382 (2012) PMID 23100514 PMCID PMC3504141

    Phagocytosis of Ab-coated pathogens is mediated through FcγRs, which activate intracellular signaling pathways to drive actin cytoskeletal rearrangements. Abl and Arg define a family of nonreceptor tyrosine kinases that regulate actin-dependent processes in a variety of cell types, including tho...
  20. Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages.

    Journal of Immunology 189(11):5382 (2012) PMID 23100514 PMCID PMC3504141

    Phagocytosis of Ab-coated pathogens is mediated through FcγRs, which activate intracellular signaling pathways to drive actin cytoskeletal rearrangements. Abl and Arg define a family of nonreceptor tyrosine kinases that regulate actin-dependent processes in a variety of cell types, including tho...