1. Is any job better than no job? Labor market experiences and depressive symptoms in people living with HIV.

    AIDS Care 27(7):907 (2015) PMID 25738528

    The purpose of this study is to determine the relationship between the psychosocial work environment and labor market experiences (including unemployment) on mental health among adults living with HIV. We used data provided by 538 participants at clinical and community sites across Ontario, Cana...
  2. Impact of age on retention in care and viral suppression.

    JAIDS Journal of Acquired Immune Deficiency Syn... 68(4):413 (2015) PMID 25559604 PMCID PMC4334738

    Retention in care is important for all HIV-infected persons and is strongly associated with initiation of antiretroviral therapy and viral suppression. However, it is unclear how retention in care and age interact to affect viral suppression. We evaluated whether the association between retentio...
  3. Impact of age on retention in care and viral suppression.

    JAIDS Journal of Acquired Immune Deficiency Syn... 68(4):413 (2015) PMID 25559604 PMCID PMC4334738

    Retention in care is important for all HIV-infected persons and is strongly associated with initiation of antiretroviral therapy and viral suppression. However, it is unclear how retention in care and age interact to affect viral suppression. We evaluated whether the association between retentio...
  4. Impact of age on retention in care and viral suppression.

    JAIDS Journal of Acquired Immune Deficiency Syn... 68(4):413 (2015) PMID 25559604

    Retention in care is important for all HIV-infected persons and is strongly associated with initiation of antiretroviral therapy and viral suppression. However, it is unclear how retention in care and age interact to affect viral suppression. We evaluated whether the association between retentio...
  5. Impact of age on retention in care and viral suppression.

    JAIDS Journal of Acquired Immune Deficiency Syn... 68(4):413 (2015) PMID 25559604 PMCID PMC4334738

    Retention in care is important for all HIV-infected persons and is strongly associated with initiation of antiretroviral therapy and viral suppression. However, it is unclear how retention in care and age interact to affect viral suppression. We evaluated whether the association between retentio...
  6. Impact of age on retention in care and viral suppression.

    JAIDS Journal of Acquired Immune Deficiency Syn... 68(4):413 (2015) PMID 25559604

    Retention in care is important for all HIV-infected persons and is strongly associated with initiation of antiretroviral therapy and viral suppression. However, it is unclear how retention in care and age interact to affect viral suppression. We evaluated whether the association between retentio...
  7. Impact of age on retention in care and viral suppression.

    JAIDS Journal of Acquired Immune Deficiency Syn... 68(4):413 (2015) PMID 25559604 PMCID PMC4334738

    Retention in care is important for all HIV-infected persons and is strongly associated with initiation of antiretroviral therapy and viral suppression. However, it is unclear how retention in care and age interact to affect viral suppression. We evaluated whether the association between retentio...
  8. Dolutegravir efficacy at 48 weeks in key subgroups of treatment-naive HIV-infected individuals in three randomized trials.

    AIDS 29(2):167 (2015) PMID 25387312

    Dolutegravir (DTG) has been studied in three trials in HIV treatment-naive participants, showing noninferiority compared with raltegravir (RAL), and superiority compared with efavirenz and ritonavir-boosted darunavir. We explored factors that predicted treatment success, the consistency of obser...
  9. Dolutegravir efficacy at 48 weeks in key subgroups of treatment-naive HIV-infected individuals in three randomized trials.

    AIDS 29(2):167 (2015) PMID 25387312 PMCID PMC4284010

    Dolutegravir (DTG) has been studied in three trials in HIV treatment-naive participants, showing noninferiority compared with raltegravir (RAL), and superiority compared with efavirenz and ritonavir-boosted darunavir. We explored factors that predicted treatment success, the consistency of obser...
  10. Dolutegravir efficacy at 48 weeks in key subgroups of treatment-naive HIV-infected individuals in three randomized trials.

    AIDS 29(2):167 (2015) PMID 25387312 PMCID PMC4284010

    Dolutegravir (DTG) has been studied in three trials in HIV treatment-naive participants, showing noninferiority compared with raltegravir (RAL), and superiority compared with efavirenz and ritonavir-boosted darunavir. We explored factors that predicted treatment success, the consistency of obser...
  11. Hospital-wide rollout of antimicrobial stewardship: a stepped-wedge randomized trial.

    Clinical Infectious Diseases 59(6):867 (2014) PMID 24928294

    Our objective was to rigorously evaluate the impact of an antimicrobial stewardship audit-and-feedback intervention, via a stepped-wedge randomized trial. An effective intensive care unit (ICU) audit-and-feedback program was rolled out to 6 non-ICU services in a randomized sequence. The primary ...
  12. Hospital-wide rollout of antimicrobial stewardship: a stepped-wedge randomized trial.

    Clinical Infectious Diseases 59(6):867 (2014) PMID 24928294

    Our objective was to rigorously evaluate the impact of an antimicrobial stewardship audit-and-feedback intervention, via a stepped-wedge randomized trial. An effective intensive care unit (ICU) audit-and-feedback program was rolled out to 6 non-ICU services in a randomized sequence. The primary ...
  13. Micronutrient deficiency and treatment adherence in a randomized controlled trial of micronutrient supplementation in ART-naïve persons with HIV.

    PLoS ONE 9(1):e85607 (2014) PMID 24465617 PMCID PMC3897458

    The MAINTAIN study is an on-going RCT comparing high-dose micronutrient and anti-oxidant supplementation versus recommended daily allowance (RDA) vitamins in slowing HIV immune deficiency progression in ART-naïve people with HIV infection. We planned analysis of the first 127 participants to det...
  14. Fanconi syndrome accompanied by renal function decline with tenofovir disoproxil fumarate: a prospective, case-control study of predictors and resolution in HIV-infected patients.

    PLoS ONE 9(3):e92717 (2014) PMID 24651857 PMCID PMC3961428

    The predictors of Fanconi syndrome (FS) accompanied by renal function decline with use of the antiretroviral tenofovir disoproxil fumarate (TDF) have not been assessed. In addition, the natural history of renal recovery from FS after TDF discontinuation is not well-described. We prospectively en...
  15. Evaluation of brief screening tools for neurocognitive impairment in HIV/AIDS: a systematic review of the literature.

    AIDS 27(15):2385 (2013) PMID 23751261 PMCID PMC3814629

    To systematically review literature on brief screening tools used to detect and differentiate between normal cognition and neurocognitive impairment and HIV-associated neurocognitive disorders (HANDs) in adult populations of persons with HIV. A formal systematic review. We searched six electroni...
  16. Evaluation of brief screening tools for neurocognitive impairment in HIV/AIDS: a systematic review of the literature.

    AIDS 27(15):2385 (2013) PMID 23751261 PMCID PMC3814629

    To systematically review literature on brief screening tools used to detect and differentiate between normal cognition and neurocognitive impairment and HIV-associated neurocognitive disorders (HANDs) in adult populations of persons with HIV. A formal systematic review. We searched six electroni...
  17. Impact of hepatitis B and C co-infection on health-related quality of life in HIV positive individuals.

    Quality of Life Research 22(7):1525 (2013) PMID 23070749

    Concurrent infection with HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) often occurs due to the commonality in risk factors for acquisition. Few studies have examined the effect of co-infection on health-related quality of life (HRQOL) in HIV positive individuals. Ontario HIV Treatme...
  18. Herpes simplex virus type 2 coinfection does not accelerate CD4 count decline in untreated HIV infection.

    Clinical Infectious Diseases 57(3):448 (2013) PMID 23572481

    Herpes simplex virus type 2 (HSV-2) reactivations are associated with increased HIV load, but whether HSV-2 coinfection accelerates HIV disease is unclear. We compared rates of CD4 count decline according to HSV-2 status in untreated HIV-infected adults. HIV-infected patients with a past period ...
  19. Evaluation of HIV and highly active antiretroviral therapy on the natural history of human papillomavirus infection and cervical cytopathologic findings in HIV-positive and high-risk HIV-negative women.

    Journal of Infectious Diseases 208(3):454 (2013) PMID 23624362

    The Canadian Women's HIV Study (CWHS) enrolled human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women in a longitudinal cohort. This analysis considered the effects of HIV and highly active antiretroviral therapy (HAART) on HPV persistence and cervical squamous intraepithel...
  20. Invasive cervical cancer risk among HIV-infected women: a North American multicohort collaboration prospective study.

    JAIDS Journal of Acquired Immune Deficiency Syn... 62(4):405 (2013) PMID 23254153 PMCID PMC3633634

    HIV infection and low CD4+ T-cell count are associated with an increased risk of persistent oncogenic human papillomavirus infection-the major risk factor for cervical cancer. Few reported prospective cohort studies have characterized the incidence of invasive cervical cancer (ICC) in HIV-infect...