1. Editorial.

    Development Genes and Evolution 226(2):63 (2016) PMID 26983601

  2. The significance and scope of evolutionary developmental biology: a vision for the 21st century.

    Evolution and Development 17(3):198 (2015) PMID 25963198

    Evolutionary developmental biology (evo-devo) has undergone dramatic transformations since its emergence as a distinct discipline. This paper aims to highlight the scope, power, and future promise of evo-devo to transform and unify diverse aspects of biology. We articulate key questions at the c...
  3. Evolutionary variations in the expression of dorso-ventral patterning genes and the conservation of pioneer neurons in Tribolium castaneum.

    Developmental Biology 400(1):159 (2015) PMID 25657058

    Insects are ideally suited for gaining insight into the evolutionary developmental mechanisms that have led to adaptive changes of the nervous system since the specific structure of the nervous system can be directly linked to the neural stem cell (neuroblast) lineages, which in turn can be trac...
  4. The evolution of early neurogenesis.

    Developmental Cell 32(4):390 (2015) PMID 25710527

    The foundation of the diverse metazoan nervous systems is laid by embryonic patterning mechanisms, involving the generation and movement of neural progenitors and their progeny. Here we divide early neurogenesis into discrete elements, including origin, pattern, proliferation, and movement of ne...
  5. Conservation and evolutionary modifications of neuroblast expression patterns in insects.

    Developmental Biology 388(1):103 (2014) PMID 24525296

    One of the major questions in evolutionary developmental neurobiology is how neuronal networks have been adapted to different morphologies and behaviour during evolution. Analyses of neurogenesis in representatives of all arthropod species have revealed evolutionary modifications of various deve...
  6. Development and staging of the water flea Daphnia magna (Straus, 1820; Cladocera, Daphniidae) based on morphological landmarks.

    EvoDevo 5(1):12 (2014) PMID 24641948 PMCID PMC4108089

    Crustaceans of the genus Daphnia are one of the oldest model organisms in ecotoxicology, ecology and evolutionary biology. The publication of the Daphnia pulex genome has facilitated the development of genetic tools to answer long-standing questions in these research fields (Science 331: 555-561...
  7. The function of Notch signalling in segment formation in the crustacean Daphnia magna (Branchiopoda).

    Developmental Biology 383(2):321 (2013) PMID 24063806

    Ten years ago we showed for the first time that Notch signalling is required in segmentation in spiders, indicating the existence of similar mechanisms in arthropod and vertebrate segmentation. However, conflicting results in various arthropod groups hampered our understanding of the ancestral f...
  8. Embryonic neurogenesis in Pseudopallene sp. (Arthropoda, Pycnogonida) includes two subsequent phases with similarities to different arthropod groups.

    EvoDevo 4(1):32 (2013) PMID 24289241 PMCID PMC3879066

    Studies on early neurogenesis have had considerable impact on the discussion of the phylogenetic relationships of arthropods, having revealed striking similarities and differences between the major lineages. In Hexapoda and crustaceans, neurogenesis involves the neuroblast, a type of neural stem...
  9. Unravelling the evolution of neural stem cells in arthropods: notch signalling in neural stem cell development in the crustacean Daphnia magna.

    Developmental Biology 371(2):302 (2012) PMID 22964415

    The genetic regulatory networks controlling major developmental processes seem to be conserved in bilaterians regardless of an independent or a common origin of the structures. This has been explained by the employment of a genetic toolkit that was repeatedly used during bilaterian evolution to ...
  10. Single-minded and the evolution of the ventral midline in arthropods.

    Developmental Biology 364(1):66 (2012) PMID 22306923

    In insects and crustaceans, ventral midline cells are present that subdivide the CNS into bilateral symmetric halves. In both arthropod groups unpaired midline neurons and glial cells have been identified that contribute to the embryonic patterning mechanisms. In the fruitfly Drosophila melanoga...
  11. Neurogenesis in the water flea Daphnia magna (Crustacea, Branchiopoda) suggests different mechanisms of neuroblast formation in insects and crustaceans.

    Developmental Biology 357(1):42 (2011) PMID 21624360

    Within euarthropods, the morphological and molecular mechanisms of early nervous system development have been analysed in insects and several representatives of chelicerates and myriapods, while data on crustaceans are fragmentary. Neural stem cells (neuroblasts) generate the nervous system in i...
  12. Conserved and novel functions for Netrin in the formation of the axonal scaffold and glial sheath cells in spiders.

    Developmental Biology 353(1):134 (2011) PMID 21334324

    Netrins are well known for their function as long-range chemotropic guidance cues, in particular in the ventral midline of vertebrates and invertebrates. Over the past years, publications are accumulating that support an additional short-range function for Netrins in diverse developmental proces...
  13. Expression patterns of neural genes in Euperipatoides kanangrensis suggest divergent evolution of onychophoran and euarthropod neurogenesis.

    PNAS 107(52):22576 (2010) PMID 21149708 PMCID PMC3012506

    One of the controversial debates on euarthropod relationships centers on the question as to whether insects, crustaceans, and myriapods (Mandibulata) share a common ancestor or whether myriapods group with the chelicerates (Myriochelata). The debate was stimulated recently by studies in chelicer...
  14. The morphological and molecular processes of onychophoran brain development show unique features that are neither comparable to insects nor to chelicerates.

    Arthropod Structure & Development 39(6):478 (2010) PMID 20696271

    The phylogenetic position of onychophorans is still being debated; however, most phylogenies suggest that onychophorans are a sister group to the arthropods. Here we have analysed neurogenesis in the brain of the onychophoran Euperipatoides kanangrensis. We show that the development of the onych...
  15. Evolution of patterning mechanisms.

    Arthropod Structure & Development 39(6):397 (2010) PMID 21034851

  16. How can conserved gene expression allow for variation? Lessons from the dorso-ventral patterning gene muscle segment homeobox.

    Developmental Biology 345(1):105 (2010) PMID 20561517

    Arthropods are common in marine, freshwater, terrestrial, and even aerial environments. The arthropod nervous systems must be adjusted to the highly diverse behaviour and requirements of the individual arthropod species. This raises the question of how the underlying patterning mechanisms have c...
  17. Compartmentalization of the precheliceral neuroectoderm in the spider Cupiennius salei: development of the arcuate body, optic ganglia, and mushroom body.

    Journal of Comparative Neurology 518(13):2612 (2010) PMID 20503430

    Similarly to vertebrates, arthropod brains are compartmentalized into centers with specific neurological functions such as cognition, behavior, and memory. The centers can be further subdivided into smaller functional units. This raises the question of how these compartments are formed during de...
  18. An arthropod cis-regulatory element functioning in sensory organ precursor development dates back to the Cambrian.

    BMC Biology 8:127 (2010) PMID 20868489 PMCID PMC2958161

    An increasing number of publications demonstrate conservation of function of cis-regulatory elements without sequence similarity. In invertebrates such functional conservation has only been shown for closely related species. Here we demonstrate the existence of an ancient arthropod regulatory el...
  19. The water flea Daphnia--a 'new' model system for ecology and evolution?

    Journal of Biology 9(2):21 (2010) PMID 20478012 PMCID PMC2871515

    Daphnia pulex is the first crustacean to have its genome sequenced. Availability of the genome sequence will have implications for research in aquatic ecology and evolution in particular, as addressed by a series of papers published recently in BMC Evolutionary Biology and BMC Genomics.
  20. 15-P041 Early Neurogenesis in the red flour beetle Tribolium castaneum

    Mechanisms of Development 126:S259 (2009)