Receptor for Advanced Glycation End Products (RAGE) Serves a Protective Role during Klebsiella pneumoniae - Induced Pneumonia.
PLoS ONE 11(1):e0141000 (2016)
Klebsiella species is the second most commonly isolated gram-negative organism in sepsis and a frequent causative pathogen in pneumonia. The receptor for advanced glycation end products (RAGE) is expressed on different cell types and plays a key role in diverse inflammatory responses. We here ai...
Kidney injury molecule-1 and the loss of kidney function in diabetic nephropathy: a likely causal link in patients with type 1 diabetes.
Diabetes Care 38(6):1130 (2015)
We evaluated the predictive value and clinical benefit of urinary kidney injury molecule (KIM)-1 for progression of diabetic nephropathy (DN) in type 1 diabetes. We also investigated its causal role for the decrease of estimated glomerular filtration rate (eGFR) by a Mendelian randomization (MR)...
Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice.
Diabetologia 58(5):1129 (2015)
The receptor for AGEs (RAGE) is linked to proinflammatory pathology in a range of tissues. The objective of this study was to assess the potential modulatory role of RAGE in diabetic retinopathy.
Diabetes was induced in wild-type (WT) and Rage (-/-) mice (also known as Ager (-/-) mice) using str...
Urinary adiponectin is an independent predictor of progression to end-stage renal disease in patients with type 1 diabetes and diabetic nephropathy.
Diabetes Care 38(5):883 (2015)
We investigated the predictive value of urinary adiponectin (uADP) for the progression of diabetic nephropathy (DN) as well as for the principal determinants of uADP concentrations.
uADP was measured in 2,090 patients with type 1 diabetes followed for a median of 5.8 (4.4-6.9) years and in 111 s...
daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans.
Diabetologia 58(2):393 (2015)
The aim of this study was to determine the protective effects of human insulin and its analogues, B28Asp human insulin (insulin aspart) and B29Lys(ε-tetradecanoyl),desB30 human insulin (insulin detemir), against glucose-induced lifespan reduction and neuronal damage in the model organism Caenorh...
Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice.
Atherosclerosis 235(2):444 (2014)
Both the renin-angiotensin system (RAS) and the receptor for advanced glycation end products (RAGE) potentiate diabetes-associated atherosclerosis (DAA). We assessed the effectiveness of concomitant RAS and RAGE inhibition on DAA.
Diabetic (5 × 55 mg/kg streptozotocin daily) and non-diabetic mal...
Nε-(carboxymethyl)lysine-receptor for advanced glycation end product axis is a key modulator of obesity-induced dysregulation of adipokine expression and insulin resistance.
Arteriosclerosis, Thrombosis, and Vascular Biology 34(6):1199 (2014)
Dysregulation of inflammatory adipokines by the adipose tissue plays an important role in obesity-associated insulin resistance. Pathways leading to this dysregulation remain largely unknown. We hypothesized that the receptor for advanced glycation end products (RAGE) and the ligand N(ε)-(carbox...
THE ROLE OF RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS AND ITS LIGAND HIGH MOBILITY GROUP BOX 1 IN AUTOIMMUNE MYOCARDITIS
Journal of the American College of Cardiology 63(12):A972 (2014)
RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization.
PLoS ONE 9(2):e89548 (2014)
RAGE regulates pro-inflammatory responses in diverse cells and tissues. This study has investigated if RAGE plays a role in immune cell mobilization and choroidal neovascular pathology that is associated with the neovascular form of age-related macular degeneration (nvAMD).
RAGE null (RAGE-/-) m...
Sp1-dependent regulation of PPARα in bone metabolism.
The International journal of oral & maxillofaci... 29(1):e107 (2014)
Successful repair and regeneration in bone tissue engineering vastly depends on proper interaction between the tissue-engineered construct and the recipient's immune system. In clinical application, adverse responses to bioartificial implants may result in chronic inflammation and loss of the im...
Methylglyoxal as a new biomarker in patients with septic shock: an observational clinical study.
Critical care (London, England) 18(6):683 (2014)
The role of reactive carbonyl species, such as methylglyoxal (MG), has been overlooked within the context of the sepsis syndrome. The aims of this study were to assess the impact of MG formation in different inflammatory settings and to evaluate its use for early diagnosis as well as prognosis o...
Urinary excretion of high molecular weight adiponectin is an independent predictor of decline of renal function in type 2 diabetes.
Acta Diabetologica 51(3):479 (2014)
Adiponectin and urinary adiponectin excretions have been ascribed a function in glomerular physiology and seem to indicate vascular disease in diabetes. The aim of this study was to compare the urinary excretion of albumin and adiponectin as predictors for decline of renal function in patients w...
The receptor for advanced glycation end products is dispensable in a mouse model of oral and esophageal carcinogenesis.
Histology and histopathology 28(12):1585 (2013)
Aberrant expression of the receptor for advanced glycation end products (RAGE) and its ligands, such as S100/Calgranulins, has been demonstrated in squamous cell carcinomas of the upper aerodigestive tract. However, the question whether RAGE signaling is causally linked with neoplastic transform...
RAGE-mediated interstitial fibrosis in neonatal obstructive nephropathy is independent of NF-κB activation.
Kidney International 84(5):911 (2013)
Urinary tract obstruction during nephron development causes tubular apoptosis, tubular atrophy, and interstitial fibrosis. Leukocyte recruitment is critical in the development of obstructive nephropathy leading to interstitial inflammation and renal fibrosis. RAGE, the receptor of advanced glyca...
Serum soluble receptor for advanced glycation end products (sRAGE) is independently associated with cigarette smoking in non-diabetic healthy subjects.
Diabetes and Vascular Disease Research 10(4):380 (2013)
This study was designed to explore the relationship between serum levels of soluble receptor for advanced glycation end products (sRAGE) and cigarette smoking in non-diabetic healthy subjects. A total of 98 non-diabetic, otherwise healthy male subjects were recruited. A fasting blood sample and ...
CD166/ALCAM mediates proinflammatory effects of S100B in delayed type hypersensitivity.
Journal of Immunology 191(1):369 (2013)
Promiscuity of pattern recognition receptors, such as receptor for advanced glycation end products (RAGE), allows for a complex regulatory network controlling inflammation. Scavenging of RAGE ligands by soluble RAGE treatment is effective in reducing delayed-type hypersensitivity (DTH), even in ...
Urinary liver-type fatty acid-binding protein and progression of diabetic nephropathy in type 1 diabetes.
Diabetes Care 36(7):2077 (2013)
Diabetic nephropathy (DN) has mainly been considered a glomerular disease, although tubular dysfunction may also play a role. This study assessed the predictive value for progression of a tubular marker, urinary liver-type fatty acid-binding protein (L-FABP), at all stages of DN.
At baseline, 1,...
Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice.
Hepatology 58(1):363 (2013)
The receptor for advanced glycation endproducts (RAGE) is a multiligand receptor and member of the immunoglobulin superfamily. RAGE is mainly involved in tissue damage and chronic inflammatory disorders, sustaining the inflammatory response upon engagement with damage-associated molecular patter...
High mobility group box 1 prolongs inflammation and worsens disease in pneumococcal meningitis.
Brain 136(Pt 6):1746 (2013)
Neutrophilic inflammation, which often persists over days despite appropriate antibiotic therapy, contributes substantially to brain damage in bacterial meningitis. We hypothesized that persistent inflammation is the consequence of a vicious cycle in which inflammation-induced cell injury leads ...
Endothelial progenitor cells in regeneration after acute lung injury: do they play a role?
American Journal of Respiratory Cell and Molecu... 48(4):399 (2013)
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common disorders in patients requiring critical care. The clinical management of these disorders is difficult and unrewarding, and thus they are among the most common causes of death in intensive care units. The activatio...