1. An Inhibitor of PIDDosome Formation.

    Molecular Cell 58(5):767 (2015) PMID 25936804 PMCID PMC4458193

    The PIDDosome-PIDD-RAIDD-caspase-2 complex-is a proapoptotic caspase-activation platform of elusive significance. DNA damage can initiate complex assembly via ATM phosphorylation of the PIDD death domain (DD), which enables RAIDD recruitment to PIDD. In contrast, the mechanisms limiting PIDDosom...
  2. Phosphatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assembles a specific CD44-Ezrin heterocomplex, as revealed by small angle neutron scattering.

    Journal of Biological Chemistry 290(10):6639 (2015) PMID 25572402 PMCID PMC4358296

    The cell adhesion molecule CD44 regulates diverse cellular functions, including cell-cell and cell-matrix interaction, cell motility, migration, differentiation, and growth. In cells, CD44 co-localizes with the membrane-cytoskeleton adapter protein Ezrin that links the CD44 assembled receptor si...
  3. Phosphatidylinositol 4,5-Bisphosphate Clusters the Cell Adhesion Molecule CD44 and Assembles a Specific CD44-Ezrin Heterocomplex, as Revealed by Small Angle Neutron Scattering.

    Journal of Biological Chemistry 290(10):6639 (2015) PMID 25572402 PMCID PMC4358296

    The cell adhesion molecule CD44 regulates diverse cellular functions, including cell-cell and cell-matrix interaction, cell motility, migration, differentiation, and growth. In cells, CD44 co-localizes with the membrane-cytoskeleton adapter protein Ezrin that links the CD44 assembled receptor si...
  4. Ligand-dependent enhancer activation regulated by topoisomerase-I activity.

    Cell 160(3):367 (2015) PMID 25619691

    The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activation, based on DNA nicking to relieve torsional stre...
  5. Ligand-dependent enhancer activation regulated by topoisomerase-I activity.

    Cell 160(3):367 (2015) PMID 25619691

    The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activation, based on DNA nicking to relieve torsional stre...
  6. Ligand-dependent enhancer activation regulated by topoisomerase-I activity.

    Cell 160(3):367 (2015) PMID 25619691

    The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activation, based on DNA nicking to relieve torsional stre...
  7. Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I.

    Nature Communications 6:7363 (2015) PMID 26067164 PMCID PMC4490356

    Type III R-M enzymes were identified >40 years ago and yet there is no structural information on these multisubunit enzymes. Here we report the structure of a Type III R-M system, consisting of the entire EcoP15I complex (Mod2Res1) bound to DNA. The structure suggests how ATP hydrolysis is coupl...
  8. Bisphosphonates inactivate human EGFRs to exert antitumor actions.

    PNAS 111(50):17989 (2014) PMID 25453081

    Bisphosphonates are the most commonly prescribed medicines for osteoporosis and skeletal metastases. The drugs have also been shown to reduce cancer progression, but only in certain patient subgroups, suggesting that there is a molecular entity that mediates bisphosphonate action on tumor cells....
  9. Bisphosphonates inactivate human EGFRs to exert antitumor actions.

    PNAS 111(50):17989 (2014) PMID 25453081 PMCID PMC4273397

    Bisphosphonates are the most commonly prescribed medicines for osteoporosis and skeletal metastases. The drugs have also been shown to reduce cancer progression, but only in certain patient subgroups, suggesting that there is a molecular entity that mediates bisphosphonate action on tumor cells....
  10. Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer.

    PNAS 111(50):17995 (2014) PMID 25453078 PMCID PMC4273392

    A variety of human cancers, including nonsmall cell lung (NSCLC), breast, and colon cancers, are driven by the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. Having shown that bisphosphonates, a class of drugs used widely for the therapy of osteoporosis and met...
  11. Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer.

    PNAS 111(50):17995 (2014) PMID 25453078 PMCID PMC4273392

    A variety of human cancers, including nonsmall cell lung (NSCLC), breast, and colon cancers, are driven by the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. Having shown that bisphosphonates, a class of drugs used widely for the therapy of osteoporosis and met...
  12. Bisphosphonates inactivate human EGFRs to exert antitumor actions.

    PNAS 111(50):17989 (2014) PMID 25453081 PMCID PMC4273397

    Bisphosphonates are the most commonly prescribed medicines for osteoporosis and skeletal metastases. The drugs have also been shown to reduce cancer progression, but only in certain patient subgroups, suggesting that there is a molecular entity that mediates bisphosphonate action on tumor cells....
  13. Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer.

    PNAS 111(50):17995 (2014) PMID 25453078 PMCID PMC4273392

    A variety of human cancers, including nonsmall cell lung (NSCLC), breast, and colon cancers, are driven by the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. Having shown that bisphosphonates, a class of drugs used widely for the therapy of osteoporosis and met...
  14. Bisphosphonates inactivate human EGFRs to exert antitumor actions.

    PNAS 111(50):17989 (2014) PMID 25453081 PMCID PMC4273397

    Bisphosphonates are the most commonly prescribed medicines for osteoporosis and skeletal metastases. The drugs have also been shown to reduce cancer progression, but only in certain patient subgroups, suggesting that there is a molecular entity that mediates bisphosphonate action on tumor cells....
  15. Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer.

    PNAS 111(50):17995 (2014) PMID 25453078

    A variety of human cancers, including nonsmall cell lung (NSCLC), breast, and colon cancers, are driven by the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. Having shown that bisphosphonates, a class of drugs used widely for the therapy of osteoporosis and met...
  16. Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer.

    PNAS 111(50):17995 (2014) PMID 25453078 PMCID PMC4273392

    A variety of human cancers, including nonsmall cell lung (NSCLC), breast, and colon cancers, are driven by the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. Having shown that bisphosphonates, a class of drugs used widely for the therapy of osteoporosis and met...
  17. Ligand-dependent Enhancer Activation Regulated by Topoisomerase-I Activity

    Cell (2014)

    The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activation, based on DNA nicking to relieve tors...
  18. An iron-sulfur cluster in the polymerase domain of yeast DNA polymerase ε.

    Journal of Molecular Biology 426(2):301 (2014) PMID 24144619 PMCID PMC4061903

    DNA polymerase ε (Polε) is a multi-subunit polymerase that contributes to genomic stability via its roles in leading strand replication and the repair of damaged DNA. Polε from Saccharomyces cerevisiae is composed of four subunits--Pol2, Dpb2, Dpb3, and Dpb4. Here, we report the presence of a [F...
  19. An iron-sulfur cluster in the polymerase domain of yeast DNA polymerase ε.

    Journal of Molecular Biology 426(2):301 (2014) PMID 24144619 PMCID PMC4061903

    DNA polymerase ε (Polε) is a multi-subunit polymerase that contributes to genomic stability via its roles in leading strand replication and the repair of damaged DNA. Polε from Saccharomyces cerevisiae is composed of four subunits--Pol2, Dpb2, Dpb3, and Dpb4. Here, we report the presence of a [F...
  20. An Iron–Sulfur Cluster in the Polymerase Domain of Yeast DNA Polymerase ε

    Journal of Molecular Biology 426(2):301 (2014)

    DNA polymerase ε (Polε) is a multi-subunit polymerase that contributes to genomic stability via its roles in leading strand replication and the repair of damaged DNA. Polε from Saccharomyces cerevisiae is composed of four subunits—Pol2, Dpb2, Dpb3, and Dpb4. Here, we report the presenc...