1. Mechanism of activation of protein kinase JAK2 by the growth hormone receptor.

    Science 344(6185):1249783 (2014) PMID 24833397

    Signaling from JAK (Janus kinase) protein kinases to STAT (signal transducers and activators of transcription) transcription factors is key to many aspects of biology and medicine, yet the mechanism by which cytokine receptors initiate signaling is enigmatic. We present a complete mechanistic mod...