1. A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy.

    Nature Cell Biology 17(7):930 (2015) PMID 26098573

    Autophagy is an essential eukaryotic pathway requiring tight regulation to maintain homeostasis and preclude disease. Using yeast and mammalian cells, we report a conserved mechanism of autophagy regulation by RNA helicase RCK family members in association with the decapping enzyme Dcp2. Under n...
  2. Rph1 mediates the nutrient-limitation signaling pathway leading to transcriptional activation of autophagy.

    Autophagy 11(4):718 (2015) PMID 25751780

    To maintain proper cellular homeostasis, the magnitude of autophagy activity has to be finely tuned in response to environmental changes. Many aspects of autophagy regulation have been extensively studied: pathways integrating signals through the master regulators TORC1 and PKA lead to multiple ...
  3. Toward an understanding of autophagosome-lysosome fusion: The unsuspected role of ATG14.

    Autophagy 11(4):583 (2015) PMID 25920502

    Although largely overlooked relative to the process of phagophore formation, the mechanism through which autophagosomes fuse with lysosomes is a critical aspect of macroautophagy that is not fully understood. In particular, this step must be carefully regulated to prevent premature fusion of an ...
  4. Rph1/KDM4 Mediates Nutrient-Limitation Signaling that Leads to the Transcriptional Induction of Autophagy.

    Current Biology 25(5):546 (2015) PMID 25660547 PMCID PMC4348152

    Autophagy is a conserved process mediating vacuolar degradation and recycling. Autophagy is highly upregulated upon various stresses and is essential for cell survival in deleterious conditions. Autophagy defects are associated with severe pathologies, whereas unchecked autophagy activity causes...
  5. Rph1/KDM4 Mediates Nutrient-Limitation Signaling that Leads to the Transcriptional Induction of Autophagy

    Current Biology 25(5):546 (2015) PMID 25660547 PMCID PMC4348152

    Background Autophagy is a conserved process mediating vacuolar degradation and recycling. Autophagy is highly upregulated upon various stresses and is essential for cell survival in deleterious conditions. Autophagy defects are associated with severe pathologies, whereas unch...
  6. Atg23 and Atg27 Act at the Early Stages of Atg9 Trafficking in S. cerevisiae.

    Traffic 16(2):172 (2015) PMID 25385507 PMCID PMC4305007

    Atg9 is a conserved multipass transmembrane protein with an essential role in autophagy. In Saccharomyces cerevisiae, it travels through the secretory pathway to a unique compartment, the Atg9 peripheral structures. These structures are then targeted to the phagophore assembly site (PAS), where ...
  7. Atg23 and Atg27 act at the early stages of Atg9 trafficking in S. cerevisiae.

    Traffic 16(2):172 (2015) PMID 25385507 PMCID PMC4305007

    Atg9 is a conserved multipass transmembrane protein with an essential role in autophagy. In Saccharomyces cerevisiae, it travels through the secretory pathway to a unique compartment, the Atg9 peripheral structures. These structures are then targeted to the phagophore assembly site (PAS), where ...
  8. An onset is an onset: Evidence from abstraction of newly-learned phonotactic constraints

    Journal of Memory and Language 78:18 (2015)

    • Adults were trained and tested in a continuous recognition memory task. • They rapidly learned novel consonant-position constraints (phonotactics). ...
  9. An onset is an onset: Evidence from abstraction of newly-learned phonotactic constraints

    Journal of Memory and Language 78:18 (2015)

    • Adults were trained and tested in a continuous recognition memory task. • They rapidly learned novel consonant-position constraints (phonotactics). ...
  10. Defining the membrane precursor supporting the nucleation of the phagophore.

    Autophagy 10(1):1 (2014) PMID 24257021

    How does the phagophore form? Which membrane acts as a platform for its biogenesis? Over the years, extensive use of microscopy techniques have led to the controversial identification of multiple potential membranes as precursors for phagophore nucleation and/or for the supply of lipids to the e...
  11. Defining the membrane precursor supporting the nucleation of the phagophore.

    Autophagy 10(1):1 (2014) PMID 24257021

    How does the phagophore form? Which membrane acts as a platform for its biogenesis? Over the years, extensive use of microscopy techniques have led to the controversial identification of multiple potential membranes as precursors for phagophore nucleation and/or for the supply of lipids to the e...
  12. Limits to sustained energy intake. XVI. Body temperature and physical activity of female mice during pregnancy.

    Journal of Experimental Biology 216(Pt 12):2328 (2013) PMID 23720802

    Lactation is the most energy-demanding phase of mammalian reproduction, and lactation performance may be affected by events during pregnancy. For example, food intake may be limited in late pregnancy by competition for space in the abdomen between the alimentary tract and fetuses. Hence, females...
  13. Limits to sustained energy intake. XVI. Body temperature and physical activity of female mice during pregnancy.

    Journal of Experimental Biology 216(Pt 12):2328 (2013) PMID 23720802

    Lactation is the most energy-demanding phase of mammalian reproduction, and lactation performance may be affected by events during pregnancy. For example, food intake may be limited in late pregnancy by competition for space in the abdomen between the alimentary tract and fetuses. Hence, females...
  14. A unique hairpin-type tail-anchored SNARE starts to solve a long-time puzzle.

    Autophagy 9(6):813 (2013) PMID 23575358 PMCID PMC3672291

    Macroautophagy mediates recycling of intracellular material by a multistep pathway, ultimately leading to the fusion of closed double-membrane structures, called autophagosomes, with the lysosome. This event ensures the degradation of the autophagosome content by lysosomal proteases followed by ...
  15. A unique hairpin-type tail-anchored SNARE starts to solve a long-time puzzle.

    Autophagy 9(6):813 (2013) PMID 23575358 PMCID PMC3672291

    Macroautophagy mediates recycling of intracellular material by a multistep pathway, ultimately leading to the fusion of closed double-membrane structures, called autophagosomes, with the lysosome. This event ensures the degradation of the autophagosome content by lysosomal proteases followed by ...
  16. Autophagosome Formation: Tracing the Source

    Developmental Cell 25(2):116 (2013)

    Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, Hamasaki e...
  17. Autophagosome Formation: Tracing the Source

    Developmental Cell 25(2):116 (2013) PMID 23639440 PMCID PMC3668556

    Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, Hamasaki e...
  18. Autophagosome formation: tracing the source.

    Developmental Cell 25(2):116 (2013) PMID 23639440 PMCID PMC3668556

    Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, Hamasaki et al. (201...
  19. The Arabidopsis cer26 mutant, like the cer2 mutant, is specifically affected in the very long chain fatty acid elongation process.

    Plant Journal 73(5):733 (2013) PMID 23384041

    Plant aerial organs are covered by cuticular waxes, which form a hydrophobic crystal layer that mainly serves as a waterproof barrier. Cuticular wax is a complex mixture of very long chain lipids deriving from fatty acids, predominantly of chain lengths from 26 to 34 carbons, which result from a...
  20. The Arabidopsis cer26 mutant, like the cer2 mutant, is specifically affected in the very long chain fatty acid elongation process.

    Plant Journal 73(5):733 (2013) PMID 23384041

    Plant aerial organs are covered by cuticular waxes, which form a hydrophobic crystal layer that mainly serves as a waterproof barrier. Cuticular wax is a complex mixture of very long chain lipids deriving from fatty acids, predominantly of chain lengths from 26 to 34 carbons, which result from a...