1. ID: 2: Paradoxical psoriasis – Unabated type I IFN production induced by TNF blockade

    Cytokine 76(1):66 (2015)

    Paradoxical psoriasis is a well-known side-effect of anti-TNF therapy affecting 2–5% of treated patients. As this side effect often necessitates cessation of the anti-TNF therapy, there is an urgent need to understand its pathogenesis. Here, we analyzed a series of 25 cases of paradoxi...
  2. Extraintestinal Manifestations of Inflammatory Bowel Disease.

    Inflammatory Bowel Diseases 21(8):1982 (2015) PMID 26154136 PMCID PMC4511685

    Extraintestinal manifestations (EIM) in inflammatory bowel disease (IBD) are frequent and may occur before or after IBD diagnosis. EIM may impact the quality of life for patients with IBD significantly requiring specific treatment depending on the affected organ(s). They most frequently affect j...
  3. Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.

    Immunity 42(6):1033 (2015) PMID 26084023 PMCID PMC4518498

    Expansion and acquisition of Th1 cell effector function requires metabolic reprogramming; however, the signals instructing these adaptations remain poorly defined. Here we found that in activated human T cells, autocrine stimulation of the complement receptor CD46, and specifically its intracell...
  4. IL-1β drives inflammatory responses to propionibacterium acnes in vitro and in vivo.

    Journal of Investigative Dermatology 134(3):677 (2014) PMID 24157462

    Acne vulgaris is potentially a severe skin disease associated with colonization of the pilo-sebaceous unit by the commensal bacterium Propionibacterium acnes and inflammation. P. acnes is considered to contribute to inflammation in acne, but the pathways involved are unclear. Here we reveal a me...
  5. Phototherapy with UVB narrowband, UVA/UVBnb, and UVA1 differentially impacts serum 25-hydroxyvitamin-D3.

    Journal of the American Academy of Dermatology 69(4):530 (2013) PMID 23850091

    Ultraviolet (UV) B radiation increases serum 25-hydroxyvitamin-D3 [25(OH)D], but the influence of UVA1 and UVA/narrowband UVB (UVBnb) phototherapy on serum vitamin D is unknown. We sought to investigate the influence of UVBnb, UVA1, and UVA/UVBnb phototherapy on serum levels of 25(OH)D and relat...
  6. Mo1720 Frequency and Chronology of Extraintestinal Manifestations in the Swiss Inflammatory Bowel Disease Cohort

    Gastroenterology 142(5):S (2012)

  7. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation.

    Nature Medicine 13(11):1316 (2007) PMID 17982463

    T helper cells can support the functions of CD8(+) T cells against persistently infecting viruses such as murine lymphocytic choriomeningitis virus (LCMV), cytomegalovirus, hepatitis C virus and HIV. These viruses often resist complete elimination and remain detectable at sanctuary sites, such a...
  8. Induced prion protein controls immune-activated retroviruses in the mouse spleen.

    PLoS ONE 2(11):e1158 (2007) PMID 17987132 PMCID PMC2063463

    The prion protein (PrP) is crucially involved in transmissible spongiform encephalopathies (TSE), but neither its exact role in disease nor its physiological function are known. Here we show for mice, using histological, immunochemical and PCR-based methods, that stimulation of innate resistance...
  9. Deliberate removal of T cell help improves virus-neutralizing antibody production.

    Nature Immunology 5(9):934 (2004) PMID 15300247

    The B cell response to lymphocytic choriomeningitis virus is characterized by a CD4(+) T cell-dependent polyclonal hypergammaglobulinemia and delayed formation of virus-specific neutralizing antibodies. Here we provide evidence that, paradoxically, because of polyclonal B cell activation, virus-...