1. S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab.

    Molecular Cancer Therapeutics 12(9):1749 (2013) PMID 23804704

    Aberrant activity of the receptor tyrosine kinases MET, AXL, and FGFR1/2/3 has been associated with tumor progression in a wide variety of human malignancies, notably in instances of primary or acquired resistance to existing or emerging anticancer therapies. This study describes the preclinical...
  2. S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab.

    Molecular Cancer Therapeutics 12(9):1749 (2013) PMID 23804704

    Aberrant activity of the receptor tyrosine kinases MET, AXL, and FGFR1/2/3 has been associated with tumor progression in a wide variety of human malignancies, notably in instances of primary or acquired resistance to existing or emerging anticancer therapies. This study describes the preclinical...
  3. [Contribution to new therapeutics against colorectal cancer: the CReMEC initiative].

    médecine/sciences 29(3):239 (2013) PMID 23544371

  4. [Contribution to new therapeutics against colorectal cancer: the CReMEC initiative].

    médecine/sciences 29(3):239 (2013) PMID 23544371

  5. Effect of high current density on the admittance response of interface states in ultrathin MIS tunnel junctions

    Solid-State Electronics 80:142 (2013)

    Highlights ► High current and interface DOS effects on admittance of molecular MIS tunnel junction. ► Low frequency interface states capacitance C(ω≈0) vs. J over six decades in current. ► Excess capacitance at very small current attributed to molecular dipolar relaxation. ...
  6. Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer.

    Clinical Cancer Research 18(19):5314 (2012) PMID 22825584

    Patient-derived xenograft models are considered to represent the heterogeneity of human cancers and advanced preclinical models. Our consortium joins efforts to extensively develop and characterize a new collection of patient-derived colorectal cancer (CRC) models. From the 85 unsupervised surgi...
  7. Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer.

    Clinical Cancer Research 18(19):5314 (2012) PMID 22825584

    Patient-derived xenograft models are considered to represent the heterogeneity of human cancers and advanced preclinical models. Our consortium joins efforts to extensively develop and characterize a new collection of patient-derived colorectal cancer (CRC) models. From the 85 unsupervised surgi...
  8. A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.

    Molecular and Cellular Biology 32(17):3585 (2012) PMID 22751931 PMCID PMC3422012

    The binding of the eukaryotic initiation factor 4E (eIF4E) to the mRNA 5' cap structure is a rate-limiting step in mRNA translation initiation. eIF4E promotes ribosome recruitment to the mRNA. In Drosophila, the eIF4E homologous protein (d4EHP) forms a complex with binding partners to suppress t...
  9. Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells.

    PLoS ONE 6(2):e17237 (2011) PMID 21390316 PMCID PMC3044743

    c-Yes, a member of the Src tyrosine kinase family, is found highly activated in colon carcinoma but its importance relative to c-Src has remained unclear. Here we show that, in HT29 colon carcinoma cells, silencing of c-Yes, but not of c-Src, selectively leads to an increase of cell clustering a...
  10. Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells.

    PLoS ONE 6(2):e17237 (2011) PMID 21390316 PMCID PMC3044743

    c-Yes, a member of the Src tyrosine kinase family, is found highly activated in colon carcinoma but its importance relative to c-Src has remained unclear. Here we show that, in HT29 colon carcinoma cells, silencing of c-Yes, but not of c-Src, selectively leads to an increase of cell clustering a...
  11. Texture Classification and Segmentation Based on Iterative Morphological Decomposition

    Journal of Visual Communication and Image Repre... 4(3):197 (1993)

    This paper presents a new method for texture classification and textured image segmentation based on grayscale mathematical morphology. It defines a recursive morphological decomposition algorithm by using a group of structuring elements with different sizes which decomposes a texture image...