1. Fertile waters for aging research.

    Cell 160(5):814 (2015) PMID 25723160

    The quest to slow aging has come far, and what used to be the domain of science fiction writers and snake oil salesmen may soon become science fact. Innovative new approaches, such as the use of the very short-lived African killifish (Harel et al.), are bridging the translational gap and bring t...
  2. Fertile Waters for Aging Research

    Cell 160(5):814 (2015)

    The quest to slow aging has come far, and what used to be the domain of science fiction writers and snake oil salesmen may soon become science fact. Innovative new approaches, such as the use of the very short-lived African killifish (Harel et al.), are bridging the translational gap a...
  3. Fertile waters for aging research.

    Cell 160(5):814 (2015) PMID 25723160

    The quest to slow aging has come far, and what used to be the domain of science fiction writers and snake oil salesmen may soon become science fact. Innovative new approaches, such as the use of the very short-lived African killifish (Harel et al.), are bridging the translational gap and bring t...
  4. A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer.

    Disease Models & Mechanisms 7(10):1165 (2014) PMID 25085991 PMCID PMC4174527

    Mutations affecting mitochondrial complex I, a multi-subunit assembly that couples electron transfer to proton pumping, are the most frequent cause of heritable mitochondrial diseases. However, the mechanisms by which complex I dysfunction results in disease remain unclear. Here, we describe a D...
  5. A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer.

    Disease Models & Mechanisms 7(10):1165 (2014) PMID 25085991 PMCID PMC4174527

    Mutations affecting mitochondrial complex I, a multi-subunit assembly that couples electron transfer to proton pumping, are the most frequent cause of heritable mitochondrial diseases. However, the mechanisms by which complex I dysfunction results in disease remain unclear. Here, we describe a D...
  6. A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer.

    Disease Models & Mechanisms 7(10):1165 (2014) PMID 25085991 PMCID PMC4174527

    Mutations affecting mitochondrial complex I, a multi-subunit assembly that couples electron transfer to proton pumping, are the most frequent cause of heritable mitochondrial diseases. However, the mechanisms by which complex I dysfunction results in disease remain unclear. Here, we describe a D...
  7. Dietary restriction and mitochondrial function link replicative and chronological aging inSaccharomyces cerevisiae

    Experimental Gerontology 48(10):1006 (2013)

    Chronological aging of budding yeast cells results in a reduction in subsequent replicative life span through unknown mechanisms. Here we show that dietary restriction during chronological aging delays the reduction in subsequent replicative life span up to at least 23days of chronolog...
  8. Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae.

    Experimental Gerontology 48(10):1006 (2013) PMID 23235143 PMCID PMC3604125

    Chronological aging of budding yeast cells results in a reduction in subsequent replicative life span through unknown mechanisms. Here we show that dietary restriction during chronological aging delays the reduction in subsequent replicative life span up to at least 23days of chronological age. ...
  9. End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging.

    FEMS Yeast Research 13(3):267 (2013) PMID 23336757 PMCID PMC3960949

    There is growing evidence that stochastic events play an important role in determining individual longevity. Studies in model organisms have demonstrated that genetically identical populations maintained under apparently equivalent environmental conditions display individual variation in life sp...
  10. End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging.

    FEMS Yeast Research 13(3):267 (2013) PMID 23336757 PMCID PMC3960949

    There is growing evidence that stochastic events play an important role in determining individual longevity. Studies in model organisms have demonstrated that genetically identical populations maintained under apparently equivalent environmental conditions display individual variation in life sp...
  11. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.

    Nature Chemical Biology 9(2):112 (2013) PMID 23222885 PMCID PMC3552084

    We sought new strategies to reduce amounts of the polyglutamine androgen receptor (polyQ AR) and achieve benefits in models of spinobulbar muscular atrophy, a protein aggregation neurodegenerative disorder. Proteostasis of the polyQ AR is controlled by the heat shock protein 90 (Hsp90)- and Hsp7...
  12. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.

    Nature Chemical Biology 9(2):112 (2013) PMID 23222885 PMCID PMC3552084

    We sought new strategies to reduce amounts of the polyglutamine androgen receptor (polyQ AR) and achieve benefits in models of spinobulbar muscular atrophy, a protein aggregation neurodegenerative disorder. Proteostasis of the polyQ AR is controlled by the heat shock protein 90 (Hsp90)- and Hsp7...
  13. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.

    Nature Chemical Biology 9(2):112 (2013) PMID 23222885 PMCID PMC3552084

    We sought new strategies to reduce amounts of the polyglutamine androgen receptor (polyQ AR) and achieve benefits in models of spinobulbar muscular atrophy, a protein aggregation neurodegenerative disorder. Proteostasis of the polyQ AR is controlled by the heat shock protein 90 (Hsp90)- and Hsp7...
  14. Fertile Waters for Aging Research

    Cell (2013)

    The quest to slow aging has come far, and what used to be the domain of science fiction writers and snake oil salesmen may soon become science fact. Innovative new approaches, such as the use of the very short-lived African killifish (Harel et al.), are bridging the translational gap a...
  15. pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast.

    Cell Cycle 11(16):3087 (2012) PMID 22871733 PMCID PMC3442919

    Chronological and replicative aging have been studied in yeast as alternative paradigms for post-mitotic and mitotic aging, respectively. It has been known for more than a decade that cells of the S288C background aged chronologically in rich medium have reduced replicative lifespan relative to ...
  16. pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast.

    Cell Cycle 11(16):3087 (2012) PMID 22871733 PMCID PMC3442919

    Chronological and replicative aging have been studied in yeast as alternative paradigms for post-mitotic and mitotic aging, respectively. It has been known for more than a decade that cells of the S288C background aged chronologically in rich medium have reduced replicative lifespan relative to ...
  17. pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast.

    Cell Cycle 11(16):3087 (2012) PMID 22871733 PMCID PMC3442919

    Chronological and replicative aging have been studied in yeast as alternative paradigms for post-mitotic and mitotic aging, respectively. It has been known for more than a decade that cells of the S288C background aged chronologically in rich medium have reduced replicative lifespan relative to ...
  18. Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice.

    PLoS Genetics 7(10):e1002321 (2011) PMID 22022281 PMCID PMC3192827

    Altered protein homeostasis underlies degenerative diseases triggered by misfolded proteins, including spinal and bulbar muscular atrophy (SBMA), a neuromuscular disorder caused by a CAG/glutamine expansion in the androgen receptor. Here we show that the unfolded protein response (UPR), an ER pr...
  19. Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice.

    PLoS Genetics 7(10):e1002321 (2011) PMID 22022281 PMCID PMC3192827

    Altered protein homeostasis underlies degenerative diseases triggered by misfolded proteins, including spinal and bulbar muscular atrophy (SBMA), a neuromuscular disorder caused by a CAG/glutamine expansion in the androgen receptor. Here we show that the unfolded protein response (UPR), an ER pr...
  20. Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.

    Journal of Biological Chemistry 285(21):15714 (2010) PMID 20348093 PMCID PMC2871437

    The Hsp90/Hsp70-based chaperone machinery regulates the activity and degradation of many signaling proteins. Cycling with Hsp90 stabilizes client proteins, whereas Hsp70 interacts with chaperone-dependent E3 ubiquitin ligases to promote protein degradation. To probe these actions, small molecule...