1. Low dose radiation response curves, networks and pathways in human lymphoblastoid cells exposed from 1 to 10cGy of acute gamma radiation.

    Mutation Research/Fundamental and Molecular Mec... 722(2):119 (2011) PMID 21497671

    We investigated the low dose dependency of the transcriptional response of human cells to characterize the shape and biological functions associated with the dose-response curve and to identify common and conserved functions of low dose expressed genes across cells and tissues. Human lymphoblast...
  2. Low dose radiation response curves, networks and pathways in human lymphoblastoid cells exposed from 1 to 10cGy of acute gamma radiation.

    Mutation Research/Fundamental and Molecular Mec... 722(2):119 (2011) PMID 21497671

    We investigated the low dose dependency of the transcriptional response of human cells to characterize the shape and biological functions associated with the dose-response curve and to identify common and conserved functions of low dose expressed genes across cells and tissues. Human lymphoblast...
  3. The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men.

    Human Reproduction 23(5):1014 (2008) PMID 18353905

    Little is known about the effect of paternal nutrition on aneuploidy in sperm. We investigated the association of normal dietary and supplement intake of folate, zinc and antioxidants (vitamin C, vitamin E and beta-carotene) with the frequency of aneuploidy in human sperm. Sperm samples from 89 ...
  4. The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men.

    Human Reproduction 23(5):1014 (2008) PMID 18353905

    Little is known about the effect of paternal nutrition on aneuploidy in sperm. We investigated the association of normal dietary and supplement intake of folate, zinc and antioxidants (vitamin C, vitamin E and beta-carotene) with the frequency of aneuploidy in human sperm. Sperm samples from 89 ...
  5. Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations.

    PNAS 104(45):17725 (2007) PMID 17978187 PMCID PMC2077046

    Male and female germ cells can transmit genetic defects that lead to pregnancy loss, infant mortality, birth defects, and genetic diseases in offspring; however, the parental origins of transmitted defects are not random, with de novo mutations and chromosomal structural aberrations transmitted ...
  6. Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations.

    PNAS 104(45):17725 (2007) PMID 17978187 PMCID PMC2077046

    Male and female germ cells can transmit genetic defects that lead to pregnancy loss, infant mortality, birth defects, and genetic diseases in offspring; however, the parental origins of transmitted defects are not random, with de novo mutations and chromosomal structural aberrations transmitted ...
  7. The effects of male age on sperm DNA damage in healthy non-smokers.

    Human Reproduction 22(1):180 (2007) PMID 17053003

    The trend for men to have children at older age raises concerns that advancing age may increase the production of genetically defective sperm, increasing the risks of transmitting germ-line mutations. We investigated the associations between male age and sperm DNA damage and the influence of sev...
  8. The effects of male age on sperm DNA damage in healthy non-smokers.

    Human Reproduction 22(1):180 (2007) PMID 17053003

    The trend for men to have children at older age raises concerns that advancing age may increase the production of genetically defective sperm, increasing the risks of transmitting germ-line mutations. We investigated the associations between male age and sperm DNA damage and the influence of sev...
  9. Quantitative effects of male age on sperm motion.

    Human Reproduction 21(11):2868 (2006) PMID 16793993

    Semen quality is associated with fertility status, but there is little quantitative information on risk factors that affect semen quality, especially in non-clinical populations. Advancing male age has been associated with a decline in semen quality, with the largest effect being on sperm motili...
  10. Quantitative effects of male age on sperm motion.

    Human Reproduction 21(11):2868 (2006) PMID 16793993

    Semen quality is associated with fertility status, but there is little quantitative information on risk factors that affect semen quality, especially in non-clinical populations. Advancing male age has been associated with a decline in semen quality, with the largest effect being on sperm motili...
  11. Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm.

    PNAS 103(25):9601 (2006) PMID 16766665 PMCID PMC1480453

    This study compares the relative effects of advancing male age on multiple genomic defects in human sperm [DNA fragmentation index (DFI), chromatin integrity, gene mutations, and numerical chromosomal abnormalities], characterizes the relationships among these defects and with semen quality, and...
  12. Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm.

    PNAS 103(25):9601 (2006) PMID 16766665 PMCID PMC1480453

    This study compares the relative effects of advancing male age on multiple genomic defects in human sperm [DNA fragmentation index (DFI), chromatin integrity, gene mutations, and numerical chromosomal abnormalities], characterizes the relationships among these defects and with semen quality, and...
  13. Antioxidant intake is associated with semen quality in healthy men.

    Human Reproduction 20(4):1006 (2005) PMID 15665024

    We seek to determine whether dietary and supplement intake of specific micronutrients (zinc and folate) and antioxidants (vitamins C, E and beta-carotene) is associated with semen quality. Ninety-seven healthy, non-smoking men provided semen and were interviewed. Average daily nutrient intake fr...
  14. Antioxidant intake is associated with semen quality in healthy men.

    Human Reproduction 20(4):1006 (2005) PMID 15665024

    We seek to determine whether dietary and supplement intake of specific micronutrients (zinc and folate) and antioxidants (vitamins C, E and beta-carotene) is associated with semen quality. Ninety-seven healthy, non-smoking men provided semen and were interviewed. Average daily nutrient intake fr...
  15. Detection of structural and numerical chromosomal abnormalities by ACM-FISH analysis in sperm of oligozoospermic infertility patients.

    Human Reproduction 19(6):1395 (2004) PMID 15117895

    Modern reproductive technologies are enabling the treatment of infertile men with severe disturbances of spermatogenesis. The possibility of elevated frequencies of genetically and chromosomally defective sperm has become an issue of concern with the increased usage of ICSI, which can enable men...
  16. Detection of structural and numerical chromosomal abnormalities by ACM-FISH analysis in sperm of oligozoospermic infertility patients.

    Human Reproduction 19(6):1395 (2004) PMID 15117895

    Modern reproductive technologies are enabling the treatment of infertile men with severe disturbances of spermatogenesis. The possibility of elevated frequencies of genetically and chromosomally defective sperm has become an issue of concern with the increased usage of ICSI, which can enable men...
  17. Gene expression changes in mouse brain after exposure to low-dose ionizing radiation.

    International Journal of Radiation Biology 79(10):759 (2003) PMID 14630535

    To characterize the cellular functions associated with the altered transcript profiles of mouse brain exposed to low-dose in vivo gamma-irradiation. Cerebral RNA was isolated at 30 min and 4 h after whole-body irradiation at 0.1 or 2 Gy, hybridized to random oligonucleotide arrays, and evaluated...
  18. Gene expression changes in mouse brain after exposure to low-dose ionizing radiation.

    International Journal of Radiation Biology 79(10):759 (2003) PMID 14630535

    To characterize the cellular functions associated with the altered transcript profiles of mouse brain exposed to low-dose in vivo gamma-irradiation. Cerebral RNA was isolated at 30 min and 4 h after whole-body irradiation at 0.1 or 2 Gy, hybridized to random oligonucleotide arrays, and evaluated...
  19. The association of age and semen quality in healthy men.

    Human Reproduction 18(2):447 (2003) PMID 12571189

    Although the effect of maternal age on fertility is well known, it is unclear whether paternal age also affects fertility. This cross-sectional study sought to characterize the association between age and semen quality, a well-known proxy of fertility status. A convenience sample of 97 non-smoki...
  20. The association of age and semen quality in healthy men.

    Human Reproduction 18(2):447 (2003) PMID 12571189

    Although the effect of maternal age on fertility is well known, it is unclear whether paternal age also affects fertility. This cross-sectional study sought to characterize the association between age and semen quality, a well-known proxy of fertility status. A convenience sample of 97 non-smoki...